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Proteoglycans (PGs) consist of a core protein with covalently bound glycosaminoglycan (GAG) chains that are linked via a tetrasaccharide. PGs are important macromolecules that are involved in biological processes such as cell growth and differentiation. A key enzyme in the biosynthesis of PG GAG chains is β-1,4-galactosyltransferase 7 (β4GalT7) that catalyzes the transfer of galactose to a xylose

Background and Goal of StudyWe aimed to develop, implement and evaluate a mobile system using off-the-shelf components, torecord and review simulations and debriefings in four separate rooms during standardized simulation courses at multiple centres in Sweden. Ourrequirements were: high quality sound and video; easy to install, use and demount; suitable for transport by courier; no requirement to

BACKGROUND: Thirty-eight years of pediatric heart transplantation (pHTx) within the Scandiatransplant organization were analyzed to describe volume trends, regional prevalence, underlying etiologies and outcomes following listing and pHTx.METHODS: Children <18 years listed for pHTx from January 1st 1986 to December 31st 2023 were identified in the Scandiatransplant registry. The cohort was split i

This document has been developed to provide practical resources to policymakers, institutional representatives, and educators, by offering a diverse range of examples and recommendations at various levels to support the implementation and enhancement of ISE.The White Book is founded on the theoretical framework of ISE developed throughout the Communities or Sciences (C4S) Towards Promoting an Incl

The paper explores the role and meaning of maṣlaḥa (social utility) and its possible appropriation in the field of Islamic legal and economic thought, as laid down by various medieval and contemporary Muslim scholars. Questions that are pertinent to the research are the following: how has maṣlaḥa been incorporated in legal reasoning and what kind of meaning does it convey; what type of economic (a

Background & Aims: Biomarkers are needed to identify individuals at elevated risk of inflammatory bowel disease. This study aimed to identify protein signatures predictive of inflammatory bowel disease. Methods: Using large population-based cohorts (n ≥180,000), blood samples were obtained from individuals who later in life were diagnosed with inflammatory bowel disease and compared with age a

Purpose There is a need for diagnostic and prognostic biosignatures to improve long-term outcomes in inflammatory bowel disease (IBD). Here, we describe the establishment of the Swedish Inception Cohort in IBD (SIC-IBD) and demonstrate its potential for the identification of such signatures. Participants Patients aged ≥18 years with gastrointestinal symptoms who were referred to the gastroenterolo

Marcus Tullius Ciceros verk Brutus, också känt under titeln De claris oratoribus, är en framställning i dialogform av talarkonsten i Rom. Cicero själv har huvudrollen i berättelsen som byggs upp kring Marcus Junius Brutus (den mest namnkunnige av de blivande Caesarmördarna) och Titus Pomponius Atticus (en nära vän till Cicero, från Athen) vilka när de råkar på Cicero ber honom berätta om den romer

The aim of this this cross-sectional observational study was to investigate coagulation and platelet activation in blood collected from newly inserted catheters. Blood samples were collected from newly inserted central venous, peripheral venous and arterial catheters in adult patients. Sample 1 was collected within seconds after insertion. Sample 2 was collected directly after Sample 1 but after p

BACKGROUND: Mental health service users often experience difficulties interpreting and regulating sensory stimuli resulting in increased anxiety, decreased abilities to engage in activities and a hampered recovery process. However, there are limited studies on the implementation of such recovery-oriented interventions targeting sensory difficulties via sensory modulation techniques. Therefore, the

Understanding the hydromechanical behavior of porous media such as sandstones is critical to various geoengineering applications such as geologic carbon storage, geothermal projects, oil and gas production and environmental remediation in aquifers. In these contexts, accurate quantification of the constitutive hydromechanical behavior of sandstones is necessary to predict reservoir responses. In t

Background: Evidence on psychological outcomes of gaming disorder (GD) is still scarce. This study aimed to investigate the mediating role of sleep hygiene in the relationship between GD and psychological distress (depression and anxiety) among Iranian adolescents. Methods: This was a cross-sectional study among school students in Qazvin city, Iran. We administered GD, anxiety, and depression ques

Background: Several cancer types have increased PFKFB3, a glycolytic enzyme for which potent inhibitors have been found. Inhibition of PFKFB3 impairs DNA repair after irradiation of cancer cells, making it a possible radiosensitization target. The SweBCG91RT trial, in which breast cancer patients were randomized to postoperative radiotherapy or not, was used to investigate PFKFB3 as a clinical mar

Monitoring agricultural land with optical remote sensing offers a valuable tool for estimating crop yield and supporting decision-making for food security. Cropland phenology indicators, such as the start of season (SOS), the end of season (EOS), and the number of growing seasons per year, provide essential information for land managers. While established toolboxes like TIMESAT have been extractin

The functionalization of cubosomes for their use in drug delivery, bioimaging, and biosensing can be achieved by incorporating molecules that are sensitive to physiological conditions, such as phospholipids. Considering this, it is relevant to investigate the interaction between phospholipid-containing cubosomes and phospholipase A2 (PLA2), a ubiquitous enzyme associated with inflammatory diseases

Photoacoustic imaging can potentially map oxygen saturation (sO2) non-invasively. However, in-vivo human application is challenging due to spectral coloring, which causes a wavelength-dependent fluence attenuation and uncertainty in the estimation of chromophore concentrations deep in tissue. This study compares the performances of two previously proposed methods for spectral coloring compensation

Surface-enhanced Raman scattering (SERS) technology can detect molecular information; Because of its high sensitivity, it is widely used in chemical analysis. In this study discussed the experimental detection of 1,4-diethynylbenzene molecule based on SERS technology. The SERS spectra of 1,4-diethynylbenzene molecule were calculated by Density Functional Theory (DFT) simulation, and the results sh

Due to the large extent of seawater surface over the globe, aerosol particles spend significant time being transported over this type of surface. Therefore, global aerosol circulation is largely impacted by the processes particles undergo during long-range transport overseas. In this study, we investigated submicron aerosol (PM1) chemical composition changes during long-range transport events over

Background: The aim was to develop a theoretical framework for how errors in estimated activities propagate to a dispersion in time-integrated activity in radionuclide-therapy dosimetry and how this affects the comparison of radionuclide-therapy dosimetry schemes. Methods: Formulae for the variance of relative errors of estimated time-integrated activities and relative differences in time-integrat

En kort, Wittgensteininfluerad betraktelse i åminnelse av Karl Dahlstrand.