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Approximation of Infinitely Divisible Random Variables with Application to the Simulation of Stochastic Processes

This thesis consists of four papers A, B, C and D. Paper A and B treats the simulation of stochastic differential equations (SDEs). The research presented therein was triggered by the fact that there were not any efficient implementations of the higher order methods for simulating SDEs. So in practice the higher order methods required at least the same amount of work as the Euler method to obtain

Physical Characterization of Actinide Particles - A Study on Novel Techniques for Radiological and Nuclear Safeguard Investigations

This thesis presents a study of advanced analytical techniques, for the characterization of actinide particles originating from the non-peaceful use of nuclear technology and from international inspections of the nuclear fuel cycle associated with non-proliferation agreements. The thesis is based on five papers, which will be referred to by Paper I-V in the text. Individual particle analysis has s

Quasielastic Scattering in the Dipole Model

A series of previous papers develops a dipole model in initial state impact parameter space that includes subleading effects such as running alpha strong, unitarity, confinement and saturation. Here some recent work is presented, where the model is applied to a new set of data: vector meson production in photon-proton, DVCS and t-dependence in elastic proton-proton collisions. This allows us to tu

Computational Prediction Models for Proteolytic Cleavage and Epitope Identification

The biological functions of proteins depend on their physical interactions with other molecules, such as proteins and peptides. Therefore, modeling the protein-ligand interactions is important for understanding protein functions in different biological processes. We have focused on the cleavage specificities of HIV-1 protease, HCV NS3 protease and caspases on short oligopeptides or in native prote

Execution trace graph analysis of dataflow programs: Bounded buffer scheduling and deadlock recovery using model predictive control

Execution trace graph analysis of dataflow programs has been demonstrated to be an effective way for exploring and optimizing the design space of many core applications. In this work a novel transformation from the execution trace graph to an event driven linear system is proposed. It is also illustrated how the trace space of can be effectively reduced and well known system control techniques can

A SUSPENDED-LOAD FORMULA OVER RIPPLED BEDS

The effects of the phase lag on the suspended load in the ripple regime were investigated for oscillatory flows and combined steady and unsteady flows. The Camenen et al. (2005) suspended load formula was modified in order to take into account both current-related and wave-related sediment transport. A particular effort was made to better predict the phase-lag effects in the ripple regime. The mod

Development of type 1 diabetes in wild bank voles associated with islet autoantibodies and the novel ljungan virus.

Wild bank voles (Clethrionomys glareolus) may develop diabetes in laboratory captivity. The aim of this study was to test whether bank voles develop type 1 diabetes in association with Ljungan virus. Two groups of bank voles were analyzed for diabetes, pancreas histology, autoantibodies to glutamic acid decarboxylase (GAD65), IA-2, and insulin by standardized radioligand-binding assays as well as

Localization of functional sites in the viral complement inhibitor KCP

Kaposi's sarcoma-associated herpes virus (KSHV) encodes a complement inhibitor named KSHV complement control protein (KCP). We have previously shown that KCP inhibits the human complement system by disrupting the C3 convertase of complement. KCP can accelerate the decay of the classical C3 convertase and it can act as a cofactor for factor I (R), which then cleaves and inactivates C4b or C3b (in t

Engineered Yeast as Biocatalyst for Stereoselective reductions of Dicarbonyl Compounds

Chiral building blocks are needed in the chemical and pharmaceutical industries for the production of fine chemicals and pharmaceuticals. The utilisation of microorganisms and enzymes to perform stereoselective reductions of carbonyl compounds is an efficient and widely applied method for the generation of chiral molecules. The aim of this thesis was to develop and improve yeast-catalysed bioredu

Handledning – perspektiv och erfarenheter

Handledning är en praktik som under senare år kommit till användning inom en lång rad olika fält, allt ifrån utbildning inom skola, universitet och arbetsliv, professionell utveckling, organisations- och ledarutveckling till kultur- och fritidsverksamheter. Handledning - perspektiv och erfarenheter fokuserar på den bredd som finns inom ämnet, där varje fält hämtar idéer och arbetssätt från variera