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Large Eddy Simulation of cavity stabilized ramjet combustion

In this study we use finite rate chemistry Large Eddy Simulation (LES) to examine flow, injection, mixing, self-ignition and turbulent combustion in a dual-mode ramjet combustor with a cavity flameholder. The target case is the dual-mode ramjet combustor studied experimentally by Micka & Driscoll in a series of publications under different operating conditions characterized by varying air stag

IGHV allele similarity clustering improves genotype inference from adaptive immune receptor repertoire sequencing data

In adaptive immune receptor repertoire analysis, determining the germline variable (V) allele associated with each T- and B-cell receptor sequence is a crucial step. This process is highly impacted by allele annotations. Aligning sequences, assigning them to specific germline alleles, and inferring individual genotypes are challenging when the repertoire is highly mutated, or sequence reads do not

Performance and emission characteristics of an ammonia/diesel dual-fuel marine engine

This study explores the challenges and possibilities of using ammonia (NH3) as a carbon-free fuel for marine propulsion in a Wärtsilä ammonia/diesel dual-fuel engine using a reactivity-controlled compression ignition (RCCI) concept. The main issues in ammonia RCCI engines are high ammonia slip and high emissions of nitrogen oxides and nitrous oxide. A joint experimental and computational investiga

Mitochondrial heteroplasmic shifts reveal a positive selection of breast cancer

BACKGROUND: Breast cancer is, despite screening, not always detected early enough and is together with other tumor types known to shed genetic information in circulation. Unlike single-copy nuclear DNA, mitochondrial DNA (mtDNA) copies range from 100s to 10,000s per cell, thus providing a potentially alternative to identify potential missing cancer information in circulation at an early stage.METH

LPS priming before plaque deposition impedes microglial activation and restrains Aβ pathology in the 5xFAD mouse model of Alzheimer's disease

Microglia have an innate immunity memory (IIM) with divergent functions in different animal models of neurodegenerative diseases, including Alzheimer's disease (AD). AD is characterized by chronic neuroinflammation, neurodegeneration, tau tangles and β-amyloid (Aβ) deposition. Systemic inflammation has been implicated in contributing to the progression of AD. Multiple reports have demonstrated uni

Traditional and Disease-Specific Risk Factors for Cardiovascular Events in Antineutrophil Cytoplasmic Antibody-Associated Vasculitis : A Multinational Retrospective Study

Objective. To investigate the occurrence of cardiovascular events (CVEs) in a large cohort of patients with antineutrophil cytoplasmic antibody (ANCA)-Associated vasculitis (AAV) across the European Union, China, Turkey, Russia, the United Kingdom, and the USA. Methods. Patients with a definite diagnosis of AAV who were followed for ? 3 months and had sufficient documentation were included. Data o

Self-diffusion coefficients of heavy water in low n-alkanes

The self-diffusion coefficients of D2O (i.e., heavy water or 2H2O) in eight n-alkanes at 298 K were investigated using 2H NMR diffusometry. D tended to decrease in the n-alkanes with increasing carbon number and be inversely proportional to the n-alkane viscosity to a fractional power. The hydrodynamic radius of D2O in the n-alkanes, calculated from Stokes-Einstein-Sutherland equation with stick b

The impact of people with mobility limitations on exit choice

Demographic trends and advances in accessibility have led to more heterogeneous populations in public buildings. While providing accessible evacuation, it may be necessary to direct evacuees to different evacuation paths depending on functional capacity. The presence of people with mobility limitations (e.g., wheelchair users) may affect the evacuation of others, possibly influencing the decision

Different Means to an end: Exploring the Methods and Objectives of the Youth Climate Movement

In September 2019, streets across the world filled with millions of children and youth demanding climate action, demonstrating the growing concern young people feel about their futures (Taylor, Watts, & Bartlett, 2019). However, protests are only one of the methods youths use to show their dissatisfaction with current climate change policies. Youth are also utilizing education, entrepreneurshi

Stereotypes and the public acceptability of shared micromobility

Understanding the public's views and acceptability of shared micromobility (SMM) is crucial for uncovering barriers to incorporating SMM into sustainable urban mobility. This research studies stereotypes of SMM and their impacts on SMM's public acceptability. We focus on shared e-scooters and shared bikes/e-bikes in England, the Netherlands, and Sweden. We conceptualise stereotypes of SMM, develop

Differences and similarities between the EULAR/ASAS-EULAR and national recommendations for treatment of patients with psoriatic arthritis and axial spondyloarthritis across Europe

This is the first report comparing EULAR and national treatment recommendations for PsA patients across Europe, and the first this decade to compare ASAS-EULAR and national treatment recommendations in axSpA patients. An electronic survey was completed from October 2021–April 2022 by rheumatologists in 15 European countries. One and four countries followed all EULAR and ASAS-EULAR recommendations,

Event boundary perception among the visually impaired in audio described films

Audio description (AD) serves a critical role in making film narratives accessible to visually impaired audiences, aiming to enhance their viewing experience and comprehension. One method to assess the comprehension of film narratives, is through an event segmentation task, wherein participants delineate the narrative unfolding into distinct meaningful events. In the present study, both sighted anAudio description (AD) serves a critical role in making film narratives accessible to visually impaired audiences, aiming to enhance their viewing experience and comprehension. One method to assess the comprehension of film narratives, is through an event segmentation task, wherein participants delineate the narrative unfolding into distinct meaningful events. In the present study, both sighted an

KEAP1 polymorphisms and neurodevelopmental outcomes in children with exposure to prenatal MeHg from the Seychelles Child Development Study Nutrition Cohort 2

BACKGROUND: Humans differ in the metabolism of the neurotoxicant methyl mercury (MeHg). This variation may be partially due to variation in genes encoding the transcription factor Nuclear factor E2-related factor 2 (NRF2) and its negative regulator Kelch-like ECH-Associated Protein 1 (KEAP1), which regulate glutathione and related transporter and antioxidant proteins that play a role in the metabo

Vascular smooth muscle–specific YAP/TAZ deletion triggers aneurysm development in mouse aorta

Inadequate adaption to mechanical forces, including blood pressure, contributes to development of arterial aneurysms. Recent studies have pointed to a mechanoprotective role of YAP and TAZ in vascular smooth muscle cells (SMCs). Here, we identified reduced expression of YAP1 in human aortic aneurysms. Vascular SMC–specific knockouts (KOs) of YAP/TAZ were thus generated using the integrin α8–Cre (I

Health Care Resource, Economic, and Readmission Implications After Acute Decompensated Aortic Stenosis–A Nationwide Study

Acute decompensated aortic stenosis (ADAS) is common. The cumulative burden of ADAS from a clinical, health care resource, and financial perspective is unknown. This study sought to assess the national impact of ADAS compared with electively treated, stable patients with aortic stenosis (non-ADAS). Using the National Readmissions Database between 2016 and 2019, patients with ADAS and non-ADAS were

Autumn mass change and winter mass loss differ between migratory and nonmigratory butterflies

Poikilotherms have two major alternative strategies to deal with the inhospitable conditions of temperate winters: hibernation or migration. The vast majority of insects spend winter in a species-specific diapause resting stage, while others remain reproductively active after having migrated to more hospitable environments in the autumn. The butterfly clade Nymphalini offers an interesting possibi

Application of composite cryogels in downstream processing - A review

The demand for efficient separation and purification methods has inspired the development of new techniques and materials for bioseparation. Conventional chromatographic columns are efficient but have difficulties capturing targets from complex media or purify large products. To address this issue, new materials that can directly purify targets from particulate-containing fluids are needed. Cryoge

Market shaping MNCs in emerging markets - stakeholder engagement and the role of embeddedness

This study delves into the phenomenon of collective market shaping in the context of multinational corporations (MNCs) in emerging markets. The study examines the firm's engagement activities and the importance of embeddedness in market shaping undeveloped in the literature. Theoretically this study builds on the literature on collective market shaping, stakeholder engagement and stakeholder embed

Predicting tool life for side milling in C45 E using Colding and Taylor tool life models

This paper investigates the possibility of using empirical tool life models to predict tool life in a side milling application in a medium carbon steel, C 45E. To do this, an extensive dataset containing 46 data points with different machining parameters are produced. Four different empirical models: Taylor's equation, Colding's equation and Extended Taylor both using depth of cut and feed as well