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Identification of a weight loss-associated causal eQTL in MTIF3 and the effects of MTIF3 deficiency on human adipocyte function

Genetic variation at the MTIF3 (Mitochondrial Translational Initiation Factor 3) locus has been robustly associated with obesity in humans, but the functional basis behind this association is not known. Here, we applied luciferase reporter assay to map potential functional variants in the haplotype block tagged by rs1885988 and used CRISPR-Cas9 to edit the potential functional variants to confirm

Illumination matters. Revisiting the Roman house in a new light

Interpreting the social complexity of the Roman house requires a careful evaluation of existing evidence. With this in mind, recent work in the field has proposed a variety of different approaches, focusing each time on a specific type of source (architecture and décor, ancient texts, material evidence from excavated houses), each in turn recursively deemed more adequate for the purpose or more fr

khp-adaptive spectral projection based discontinuous Galerkin method for the numerical solution of wave equations with memory

In this paper, we present an adaptive spectral projection based finite element method to numerically approximate the solution of the wave equation with memory. The adaptivity is not restricted to the mesh (hp-adaptivity), but it is also applied to the size of the computed spectrum (k-adaptivity). The meshes are refined using a residual based error estimator, while the size of the computed spectrum

Development of Self Watering Planter

Both during and after the pandemic, the trend of biophilic design has reached maximum acceleration. One of the consequences being an increasing interest in gardening and plant care in general. Though not everybody might have so called ‘green fingers’, everyone should have the opportunity to try, and a product that facilitates horticulture is the self watering planter. IKEA of Sweden is looking int

Land and Freshwater Complex Interactions in Boreal Forests: A Neglected Topic in Forest Management

Aquatic and terrestrial habitats are interdependent components of the boreal forest landscape involving multiple dynamic interactions; these are manifested particularly in riparian areas, which are key components in the forest landscape. However, this interdependence between aquatic and terrestrial habitats is not adequately accounted for in the current management of forest ecosystems. Here we rev