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OBJECTIVE: To evaluate if opioid-free anaesthesia (OFA), is non-inferior to standard of care (SOC), in patients at low risk for acute postoperative pain (APOP).DESIGN: Patient- and assessor-blinded, non-inferiority, randomised, controlled trial.SETTING: Single centre between March 2022 to February 2024.PATIENTS: 154 adult patients, ASA I - II, planned for elective laparoscopic surgery and risk-cla

Thirty years on, gender mainstreaming is still a dominant strategy for working with gender equality, even though its effectiveness is debated. This is also the case in Sweden. This study focuses on how organisations in public administration, particularly municipalities and regions, are introduced to and approach gender mainstreaming. It aims to contribute with in-depth knowledge of how organisatioThirty years on, gender mainstreaming is still a dominant strategy for working with gender equality, even though its effectiveness is debated. This is also the case in Sweden. This study focuses on how organizations in public administration, particularly municipalities and regions, are introduced to and approach gender mainstreaming. It aims to contribute with in-depth knowledge of how organizatio

Understanding vegetation sensitivity to hydroclimate factors, especially how carbon and water cycles respond to climate change, is crucial for assessing ecosystem vulnerability. However, the seasonal sensitivity of carbon and water fluxes to temperature, radiation, soil water content, and vapor pressure deficit across diverse biomes and climates remains unclear. Here, we use 196 eddy covariance ob

Vegetation demographic models (VDMs) are advanced tools for simulating forest responses to climate and land-use changes, and are essential for projecting carbon cycling and large-scale forest management strategies. Despite their increasing incorporation into Earth System Models, VDMs differ in their demographic assumptions, with no prior quantitative comparison of their performance. We benchmarked

Disturbances play a key role in forest dynamics globally, with various effects on productivity. Tree diversity is expected to attenuate the negative impact of disturbance on forest productivity, but its overall effect has been little explored and might depend on the functional composition. Here, we analysed whether forest productivity responses to disturbances were modulated by structural and func

Multiple studies have demonstrated that cancer cells with microsatellite instability (MSI) are intolerant to loss of the Werner syndrome helicase (WRN), whereas microsatellite-stable (MSS) cancer cells are not. Therefore, WRN represents a promising new synthetic lethal target for developing drugs to treat cancers with MSI. Given the uncertainty of how effective inhibitors of WRN activity will prov

Homologous recombination (HR) is an important route for repairing DNA double-strand breaks (DSBs). The early stages of HR are well understood, but later stages remain mysterious. In this issue of Genes & Development, Hustedt and colleagues (pp. 1397–1415) reveal HROB as a new player in HR required for recruitment of the MCM8–9 complex, which is paralogous to the MCM2–7 replicative helicase. HR

DNA sequence and epigenetic information embedded in chromatin must be faithfully duplicated and transmitted to daughter cells during cell division. However, how chromatin assembly and DNA replication are integrated remains unclear. We examined the contribution of the Tousled-like kinases 1 and 2 (TLK1/TLK2) to chromatin assembly and maintenance of replication fork integrity. We show that TLK activ

Transboundary crises often create a problem of fit, where existing institutional structures are inadequate to meet the demands of the situation, requiring strategic adaptations. This study examines how Italy, Sweden, and Norway, in different ways, addressed national-level leadership needs of decision-making, coordination, and information flow during the early onset of the COVID-19 pandemic, not on

While a naive algorithm for multiplying two 2 × 2 matrices requires eight multiplications and four additions, Strassen showed how to compute the same matrix product using seven multiplications and 18 additions. Winograd reduced the number of additions to 15, which was assumed to be optimal. However, by introducing a change of basis, Karstadt and Schwartz showed how to lower the number of additions

Histone chaperones control nucleosome density and chromatin structure. In yeast, the H3-H4 chaperone Spt2 controls histone deposition at active genes but its roles in metazoan chromatin structure and organismal physiology are not known. Here we identify the Caenorhabditis elegans ortholog of SPT2 (CeSPT-2) and show that its ability to bind histones H3-H4 is important for germline development and t

Genotoxic DNA double-strand breaks (DSBs) can be repaired by error-free homologous recombination (HR) or mutagenic non-homologous end-joining 1 . HR supresses tumorigenesis 1 , but is restricted to the S and G2 phases of the cell cycle when a sister chromatid is present 2 . Breast cancer type 1 susceptibility protein (BRCA1) promotes HR by antagonizing the anti-resection factor TP53-binding prote

During DNA replication, chromatin is reassembled by recycling of modified old histones and deposition of new ones. How histone dynamics integrates with DNA replication to maintain genome and epigenome information remains unclear. Here, we reveal how human MCM2, part of the replicative helicase, chaperones histones H3-H4. Our first structure shows an H3-H4 tetramer bound by two MCM2 histone-binding

To evaluate the behaviour of a single timber-concrete composite (TCC) T-beam, a simplified 2D finite element (FE) model in Abaqus is developed and validated using experimental tests and the Gamma method given in Annex B of EN 1995–1-1. The shear connection used in the beam consist of perfobond connectors, which are adhesively bonded to the timber beam. In the developed model, beam and shell finite

In timber-concrete composites (TCC), more researchers are trying to find the “ultimate” shear connector, which combines multiple advantages. Bonded steel plates are one of the possible solutions. This paper provides an analytical and a numerical approach, calibrated with previously conducted experiments, to predict the load carrying capacity, and corresponding governing failure mode, of perfobond

With the need of renovation in the current timber structures, use of a cement based layer is a popular solution, which improves the structural integrity and increases the structural mass. In this paper, the use of a lightweight concrete with dowel type connections is investigated since such a combination can serve for both new and existing structures. Two types of dowel connections are experimenta