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Exploiting blood-based biomarkers to align preclinical models with human traumatic brain injury

Rodent models are important research tools for studying the pathophysiology of traumatic brain injury (TBI) and developing new therapeutic interventions for this devastating neurological disorder. However, the failure rate for the translation of drugs from animal testing to human treatments for TBI is 100%. While there are several potential explanations for this, previous clinical trials have reli

Resource expenditure for bridges in Sweden - do we build greener bridges now compared to 50 years ago?

The building and construction sector is responsible for a significant portion of embodied and energy related carbon emissions. Efforts to reduce this are reflected in the need for improved sustainability in the design, construction, and operation of structures such as buildings and bridges. This issue has become more prominent in recent decades due to the ongoing climate crisis. A historical revie

Indoor air pollution in low-income countries - assessment and characterization of particulate matter from cooking with solid biofuels

Based on field measurements in 26 Ethiopian homes, we have estimated an average indoor air exchange rate (AER). In laboratory settings, using on-line methods, we have burned common solid biofuels (charcoal, wood, cow dung, crops residue) in a traditional way, thereby generated airborne particles, and assessed various aerosol characteristics. All the fuels generated PM2.5 (particles smaller than 2.

A 29.5 GHz Rectifier with 14.5 dB Dynamic Power Range for Energy Harvester Using Vertical Nanowire Tunnel FETs

To extend the output DC power range of energy harvester from μW to mW, the 29.5 GHz rectifier using vertical nanowire Tunnel Field-Effect Transistor (VNW-TFET) is presented in this paper. Advantaged by the low threshold voltage, very steep characteristics, and its ability to operate below 60mV/decade, VNW-TFET is a promising device in rectifier design for low power applications. By analyzing the r

Non-technical skills in engineering education as a concept

To have a successful career in engineering, students need both technical engineering skills and non-technical engineering skills (NTES) in the transition to professional life. To address NTES in engineering education, the concept of six compulsory ‘engineering days’ were introduced in two engineering programs at the undergraduate level. The importance of different NTES for industry has been evalua

A note on judgments and behavior : Distancing and Corona virus exposure

In a questionnaire, participants judged the increase in SARS-CoV-2 virus exposure when moving closer to an infected person. Earlier studies have shown that the actual increase in virus exposure is underestimated and the present study replicated and extended these studies. The primary purpose was to investigate to what extent questionnaire judgments about hypothetical situations can predict judgmen

“Royalism in Cambodia Today” : An Interview with Prince Sisowath Thomico

In this interview, Prince Sisowath Thomico, a cousin of Cambodian King Sihamoni who has been politically active in a range of political movements and parties, discusses the role of the monarchy and what royalism might mean in Cambodia today, three decades after the Cambodian monarchy was reintroduced. He reflects on the historical trajectory of the Cambodian monarchy and royalism, and analyses how

Prevalence of Atrial Fibrillation and Long-Term Survival of Older Adults; Findings from the SNAC Study

Objective: This study examined the prevalence and long-term survival of atrial fibrillation (AF) in the older population. Methods: Data was recruited from the longitudinal SNAC study from baseline (2001–2004) for up to 10 years. Results: The population comprised 6,904 persons (59% women) (mean age 73.9 years). The prevalence of AF was 4.9% and increased with age. The hazard ratio (HR) for death in

Worst Case Analysis : A Video Analysis Approach to Injury Potential in Traffic

This paper presents a method for evaluating the potential for injury in any traffic scenario involving road user interactions based on trajectory data from a few hours of data of typical traffic conditions. The basic idea was to evaluate to what extent interactions at a location are limited in speed, direction, and whether the interactions happen at a safe speed. Specifically, the method works by

Diagnosis of Alzheimer's disease using plasma biomarkers adjusted to clinical probability

Recently approved anti-amyloid immunotherapies for Alzheimer's disease (AD) require evidence of amyloid-β pathology from positron emission tomography (PET) or cerebrospinal fluid (CSF) before initiating treatment. Blood-based biomarkers promise to reduce the need for PET or CSF testing; however, their interpretation at the individual level and the circumstances requiring confirmatory testing are p

Mars in Science Fiction and Our Perceptions of the Red Planet

Mars science fiction (SF) has interacted with Mars science ever since the advent of modern science, and has largely influenced public perceptions of the red planet and its exploration. In this chapter, it is argued that it has not only shaped numerous (mis)conceptions about the possibilities of indigenous Martian life, eventual human settlement and its challenges, but that it also has a large outr

"Det är ett liv som är motsatsen till frihet" - en jämförande analys av män och kvinnor i en hederskontext utifrån podcasts

The purpose of this study was to examine men’s and women’s experiences of honor-based violence through six podcast episodes and to identify any differences and similarities between the genders. The theoretical frameworks applied in this study to understand honor-based violence were intersectionality and Foucault’s theory of power. A purposeful selection was used to select six episodes in total. Al

Mellan ensamhet och gemenskap - En kvalitativ intervjustudie om en mötesplats betydelse för äldres upplevelse av ensamhet.

This study aimed to understand how older adults experience loneliness and how a community center can reduce feelings of loneliness. Using a qualitative method, we conducted semi-structured interviews with six older adults, aged 65 and above, who regularly visit a community center in Skåne. The analysis focuses on three different themes: experiences of loneliness, the meaning of social life, and th

Crack growth rates for short fatigue cracks in the vicinity of a low angle grain boundary

The interaction between a low angle grain boundary in front of a crack tip and the emerging plasticity from the tip of a microstructurally short edge crack subjected to fatigue loading has been studied. The modeling rests solely on discrete dislocations, were the geometry is described by dislocation dipole elements in a boundary element approach and the plasticity, restricted to one slip plane, to

Fatigue crack growth in the vicinity of a grain boundary modelled using a discrete dislocation technique

It is well known that the behaviour of short cracks differs from that of long cracks due to the relatively large plastic zone and strong influence from the surrounding microstructure, and for very low growth rates, it is important to account for discrete dislocations within the material. In this study, a discrete dislocation model is presented for the study of the growth behaviour of a short edge