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Biofluids that contain stable calcium phosphate nanoclusters sequestered by phosphopeptides make it possible for soft and hard tissues to co-exist in the same organism with relative ease. The stability diagram of a solution of nanocluster complexes shows how the minimum concentration of phosphopeptide needed for stability increases with pH. In the stable region, amorphous calcium phosphate cannot
Novel autonomous search and rescue systems, although powerful, still require a human decision-maker involvement. In this project, we focus on the human aspect of one such novel autonomous SAR system. Relying on the knowledge gained in a field study, as well as through the literature, we introduced several extensions to the system that allowed us to achieve a more user-centered interface. In the ev
Adiabatic elimination methods allow the reduction of the space dimension needed to describe systems whose dynamics exhibit separation of timescale. For open quantum systems, it consists in eliminating the fast part assuming it has almost instantaneously reached its steady state and obtaining an approximation of the evolution of the slow part. These methods can be applied to eliminate a linear subs
PurposeThe purpose of this paper is to investigate public partners’ motives for seeking and/or accepting partnerships with third sector organisations.Design/methodology/approachThe approach is to seek to identify and explain motives from different perspectives; as responses to government failure or voluntary failure, as related to governance structures, and/or as driven by resource dependencies. T
This thesis explores how the tumour microenvironment affects the phenotype and shapes the evolution of cancer cells. It encompasses four separate studies:First, we explored the effect of chemokines on the peritotumoral microenvironment of ovarian cancer. We found that C-C Motif Chemokine Ligand 2 (CCL2) secreted from mesothelial cells is a dominant chemokine promoting the peritoneal dissemination
Sclerosing epithelioid fibrosarcoma (SEF) is an aggressive soft tissue sarcoma. In the majority of cases, there is overexpression of MUC4, and most cases show EWSR1-CREB3L1 gene fusions. A subset of SEF displays composite histologic features of SEF and low-grade fibromyxoid sarcoma (LGFMS). These "hybrid" tumors are more likely to harbor the FUS-CREB3L2 fusion, which is also seen in most LGFMS. We
Under strecket
Abstract: Reports and studies repeatedly indicate that foreign languages other than English are facing major challenges in European educational systems (European Commission, 2012). In Sweden, pupils’ motivation to learn a second foreign language (SFL) is reported to be low while motivation to learn English is high (Eurobarometer 2012, Tholin & Lindqvist 2009). While there are plenty of studiesAbstract: Reports and studies repeatedly indicate that foreign languages other than English are facing major challengesin European educational systems (European Commission, 2012). In Sweden, pupils’ motivation to learn a secondforeign language (SFL) is reported to be low while motivation to learn English is high (Eurobarometer 2012, Tholin& Lindqvist 2009). While there are plenty of studies st
Electric quadrupole matrix elements, Mp, for the Jπ=2+→0+, ΔT=0, T=1 transitions across the A=46 isobaric multiplet 46Cr-46V-46Ti have been measured at GSI with the FRS-LYCCA-AGATA setup. This allows direct insight into the isospin purity of the states of interest by testing the linearity of Mp with respect to Tz. Pairs of nuclei in the T=1 triplet were studied using identical reaction mechanisms
Mobile and wireless data are in increasing demand worldwide. New trends such as the Internet of Things paradigm and the Smart City paradigm describe scenarios comprising thousands of devices all exchanging information amongst themselves wirelessly --- or through the WAN to another device, possibly connected to another WLAN. Operators and radio engineers are faced with the problem of designing effi
BackgroundThe majority of people with dementia prefer to live independently and safely in their own home cared for by their family members. Much effort has been invested in the development of technology, such as sensor‐based networks. Many challenges remain, in particular gaining more knowledge about their experiences and perceived benefits. This study aimed to explore experiences, needs and benef
Figurative language repositories typically encompass expressions that are coded manually in formal content analyses. This chapter proposes to discuss a number of theoretical and methodological issues related to mereology – the study of parts, wholes, and their relation – that are crucial for coding part–whole figurative expressions. This contribution draws the attention to the importance of: disti
Neuromuscular disorders are often caused by heterogeneous mutations in large, structurally complex genes. Targeting compensatory modifier genes could be beneficial to improve disease phenotypes. Here we report a mutation-independent strategy to upregulate the expression of a disease-modifying gene associated with congenital muscular dystrophy type 1A (MDC1A) using the CRISPR activation system in m
Circulating microRNAs (miRNAs) are being considered as non-invasive biomarkers for disease progression and clinical trials. Congenital muscular dystrophy with deficiency of laminin α2 chain (LAMA2-CMD) is a very severe form of muscular dystrophy, for which no treatment is available. In order to identify LAMA2-CMD biomarkers we have profiled miRNAs in urine from the dy2J /dy2J mouse model of LAMA2-
Fossilized eyes permit inferences of the visual capacity of extinct arthropods1–3. However, structural and/or chemical modifications as a result of taphonomic and diagenetic processes can alter the original features, thereby necessitating comparisons with modern species. Here we report the detailed molecular composition and microanatomy of the eyes of 54-million-year-old crane-flies, which togethe
