Background - Cardiovascular risk factors tend to aggregate. The biological and predictive value of this aggregation is questioned and genetics could shed light on this debate. Our aims were to reappraise the impact of risk factor confluence on ischemic heart disease (IHD) risk by testing whether genetic risk scores (GRSs) associated with these factors interact on an additive or multiplicative scal

To evaluate the potential of monoolein-based cubic bicontinuous liquid crystalline nanoparticles (cubosomes) as diagnostic tools in diabetes and pancreatic β-cell transplantation, fluorescent cubosomes were formulated, entrapping within the lipid bilayer a newly synthesized, potent, hydrophobic dye. Cryo-TEM, SAXS, and DLS were performed to assess the morphological and structural aspects of this f

In acute coronary syndromes without ST-segment elevation (NSTE-ACS), identification of the culprit artery is, most often, not possible. In this case report, we elaborate on the likelihood of different culprit arteries in a patient with NSTE-ACS. While her symptoms were progressing, typical ECG findings of ischemia in the left coronary territories were diminishing. Instead, dynamic T-wave changes i

Aim. We discuss technical points, the safety, and efficacy of ultrasonic bone shaver in various spinal surgeries within our own series. Methods. Between June 2010 and January 2014, 307 patients with various spinal diseases were operated on with the use of an ultrasonic bone curette with microhook shaver (UBShaver). Patients' data were recorded and analyzed retrospectively. The technique for the us

Urban planning processes are complex and multidimensional and they require re-thinking of traditional approaches. One of the theories increasingly researched by urban planners is realisation of participatory planning to facilitate public participation. This approach, as an effective bottom-up method, should increase the capabilities of planners to solve urban problems by including the general publ

Innehåll: Ledare (Michael Tapper), Från shejk till terrorist: Film och orientalism (Ulf Zander), The Good War: Andravärldskrigsfilm kring 2000 (Nicholas J Cull). Debate - Polonsky, Politics and the Hollywood Blacklist: Polonsky and Politics (Arthur M Eckstein), How Boris of Hollywood Saved Western Civilization (Paul Buhle & Dave Wagner), A Response to Paul, Buhle and Dave Wagner (Arthur M Ecks

To meet the challenges of consistent performance, low communication latency, and a high degree of user mobility, cloud and Telecom infrastructure vendors and operators foresee a Mobile Cloud Network that incorporates public cloud infrastructures with cloud augmented Telecom nodes in forthcoming mobile access networks. A Mobile Cloud Network is composed of distributed cost- and capacity-heterogeneo

Aims: The aim of this study was to evaluate clinical outcome for different indications for PCI in an unselected, nationwide PCI population at short-and long-term follow-up. Methods and results: We evaluated clinical outcome up to six years after PCI in all patients undergoing a PCI procedure for different indications in Sweden between 2006 and 2010. A total of 70,479 patients were treated for stab

Breast cancer is diagnosed by a combination of modalities. Measuring the elasto-mechanical properties of suspicious lesions, by e.g. ultrasound elastography, can help differentiate malignant from benign findings. Using a prototype Mechanical Imaging (MI) system as an adjunct to mammography, the aim of this study was to characterize tumors using MI and compare the readings to those from the contral

Background: The contribution of kinesiophobia (fear of movement) to the pain experience among older adults has been poorly evaluated. The aim of this study was to study prevalence at baseline, development over a 12-month period and cognitive-affective variables of kinesiophobia in a population-based sample of older adults with chronic pain. Methods: The study included 433 older adults (+65 years)

Uncultivated field boundaries constitute a significant part of the remaining semi-natural habitat in simplified agricultural landscapes, providing habitats for many grassland species. In Europe, agri-environment schemes (AES) offer incentives to farmers to manage farmland more environmentally friendly. In Sweden, one AES has specifically targeted management of incidental habitats on farmland by pr

Transplantation of DA neurons is actively pursued as a restorative therapy in Parkinson's disease (PD). Pioneering clinical trials using transplants of fetal DA neuroblasts have given promising results, although a number of patients have developed graft-induced dyskinesias (GIDs), and the mechanism underlying this troublesome side effect is still unknown. Here we have used a new model where the ac

The electromagnetic far field, as well as the near field, originating from light interaction with a red blood cell ~RBC! volume-equivalent spheroid, was analyzed by utilizing the T-matrix theory. This method is a powerful tool that makes it possible to study the influence of cell shape on the angular distribution ofscattered light. General observations were that the three-dimensional shape, as wel

BACKGROUND: The aim was to assess time trend of mortality with musculoskeletal disorders (MSD) as underlying cause of death in Sweden from 1997 to 2013.METHODS: We obtained data on MSD as underlying cause of death across age and sex groups from the National Board of Health and Welfare's Cause of Death Register. Age-standardized mortality rates per million population for all MSD, its six major subg

OBJECTIVE: Glucose degradation products (GDPs) are important for the outcome of peritoneal dialysis (PD) treatment. The most cytotoxic GDP found in conventionally manufactured fluids, 3,4-dideoxyglucosone-3-ene (3,4-DGE), may in addition be recruited from 3-deoxyglucosone (3-DG). What happens with the GDPs in the fluid infused into patients during PD is not known. We investigated whether 3,4-DGE a

Modern society is increasingly dependent on IT-systems. Due to this dependence it is importantthat IT-networks are designed to be resilient, meaning that they will either maintain or quickly recover theirfunctionality when exposed to strain. Simulation-based methods that consider supply network topology as wellas system responsible for repairing supply network have previously been used and found t

Diabetes mellitus is a group of diseases characterized by chronic hyperglycemia. Women who develops hyperglycemia for the first time during pregnancy receive the diagnosis gestational diabetes mellitus (GDM). Presently, there is no consensus about the diagnostic criteria for GDM. A majority of these women subsequently develop postpartum overt diabetes making it important to identify these patients

Background: Maintaining and improving the quality of prosthetics and orthotics education at the Tanzania Training Centre for Orthopaedic Technologists is essential for the provision of appropriate prosthetics and orthotics services in African countries. Aim: To describe how Tanzanian and Malawian graduates’ of the Diploma in Orthopaedic Technology perceive their education and how it could be impro

Introduction: In Sierra Leone, West Africa, there are many people with disabilities in need of rehabilitation services after a long civil war. Sierra Leone is among the ten least developed countries in the world and half of the population live under the absolute poverty line with an income less than $1.25 a day. Aim: The aim of this qualitative study was to explore the experiences of prosthetic an

We manipulate the information subjects can share on the web concerning socially sensitive actions (public good contribution) and visibility (selfie) to determine the effect on social image, as captured by the price subjects demand for publication. The overall conclusion from the experiment is that theory about social reputation can predict subjects' social-signaling behavior. People take costly de