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Considerations for the use of gonadotropin-releasing hormone agonists and antagonists in patients with prostate cancer

Prostate cancer is the second most common cause of cancer-related deaths in men, representing a major source of morbidity and mortality. Androgen deprivation therapy is the primary treatment for patients with advanced prostate cancer at disease presentation, which can be achieved either with surgical or chemical castration. The development of gonadotropin-releasing hormone agonists revolutionized

A novel method for creatinine adjustment makes the revised Lund–Malmö GFR estimating equation applicable in children

The aim of this study was to establish creatinine growth curves separately for males and females that can be used to adjust childhood levels of serum creatinine to corresponding adult levels. Linear regression with fractional polynomials of age as independent variable was used to construct creatinine growth curves for a reference cohort (n = 83,157 samples from Belgium and Sweden, age 2–40 years).

Persistence of avian haemosporidians in the wild : a case study to illustrate seasonal infection patterns in relation to host life stages

Infection patterns of avian haemosporidians result from the evolution of their associations with hosts, and can be shaped by multiple biotic factors. However, at the level of parasite species, few studies have investigated the details of the temporal dynamics of infection patterns in wild bird communities. We hereby studied a wild bird community in southern Sweden to investigate two generalist par

Effect of wall conduction on the heat transfer characteristics of supercritical n-decane in a horizontal rectangular pipe for cooling of a scramjet combustor

Purpose: The purpose of this paper is to numerically study the influence of wall conduction on the heat transfer of supercritical n-decane in the active regenerative cooling channels. Design/methodology/approach: A horizontally placed rectangular pipe with a solid zone and another one without a solid zone were used. A drastic variation of thermo-physical properties was emphatically addressed. Afte

To what extent are perfusion defects seen by myocardial perfusion SPECT in patients with left bundle branch block related to myocardial infarction, ECG characteristics, and myocardial wall motion?

Introduction: We investigated if uptake pattern on myocardial perfusion SPECT (MPS) in patients with left bundle branch block (LBBB) is related to myocardial fibrosis, myocardial wall motion, and electrocardiography (ECG) characteristics. Methods: Twenty-three patients (9 women) with LBBB, examined with MPS and cardiac magnetic resonance (CMR), were included. Tracer uptake on MPS was classified by

Consumption of red meat, genetic susceptibility, and risk of LADA and type 2 diabetes

Purpose: Red meat consumption is positively associated with type 1 (T1D) and type 2 (T2D) diabetes. We investigated if red meat consumption increases the risk of latent autoimmune diabetes in adults (LADA) and T2D, and potential interaction with family history of diabetes (FHD), HLA and TCF7L2 genotypes. Methods: Analyses were based on Swedish case–control data comprising incident cases of LADA (n

Using a word association task to investigate semantic depth in Swedish-speaking children with Developmental Language Disorder

We examined word associations in Swedish children with Developmental Language Disorder (DLD) compared to their typically developing (TD) peers. Furthermore, the study aimed to explore the dimensions of vocabulary knowledge (breadth, depth, and fluency) in these children. Fifty children (15 DLD and 35 TD) participated in the study, aged six to nine years. This age span is commonly associated with s

The sub-band structure of atomically sharp dopant profiles in silicon

The downscaling of silicon-based structures and proto-devices has now reached the single-atom scale, representing an important milestone for the development of a silicon-based quantum computer. One especially notable platform for atomic-scale device fabrication is the so-called Si:P δ-layer, consisting of an ultra-dense and sharp layer of dopants within a semiconductor host. Whilst several alterna

Combining multi-phase field simulation with neural network analysis to unravel thermomigration accelerated growth behavior of Cu6Sn5 IMC at cold side Cu–Sn interface

In Pb-free solder alloys used in solder balls of diameter of 50 µm or smaller, larger proportion of Cu6Sn5 intermetallics formation is a major reliability concern, and this is aggravated in presence of external thermal gradient. A complete understanding of the mechanism for intermetallics compound (IMC) growth under thermomigration is essential for devising solder materials resistant to degradatio

Taking science by surprise : The knowledge politics of the IPCC Special Report on 1.5 degrees

The role of the IPCC as a boundary, or hybrid organization, between science and policy has been well-documented. Much of this research focuses on the role that the IPCC has had in shaping policy outcomes, or how its limitations have potential impacts in uptake and political acceptability of its knowledge claims. Less has been said on its role as an organizer of scientific research. This paper take

Platelet function/reactivity testing and prediction of risk of recurrent vascular events and outcomes after TIA or ischaemic stroke : systematic review and meta-analysis

Background: The prevalence of ex vivo ‘high on-treatment platelet reactivity (HTPR)’ and its relationship with recurrent vascular events/outcomes in patients with ischaemic cerebrovascular disease (CVD) is unclear. Methods: A systematic review and meta-analysis was performed in accordance with the PRISMA statement. MEDLINE, EMBASE and Cochrane Library were searched for completed manuscripts until

Effects of Changes in Biopolymer Composition on Moisture in Acetylated Wood

To investigate the effects of changes in biopolymer composition on moisture in acetylated poplar wood (Populus euramericana Cv.), the acetylation of control wood was compared to the acetylation of wood with reduced hemicellulose or lignin content (about 9% reduction of total specimen dry weight in both cases). Time-domain nuclear magnetic resonance relaxometry of water-saturated wood gave spin–spi

Socioeconomic sequelae of drug abuse in a Swedish national cohort

Background: Drug abuse is frequently associated with negative sequelae such as reduced socioeconomic functioning. The extent to which these associations are attributable to a causal role of the disorder versus confounding factors that increase risk for both drug abuse and negative socioeconomic outcomes is unclear. Methods: Drug abuse cases were identified using Swedish national medical, pharmacy,

Toward a consensus description of vocal effort, vocal load, vocal loading, and vocal fatigue

Purpose: The purpose of this document is threefold: (a) review the uses of the terms “vocal fatigue,” “vocal effort,” “vocal load,” and “vocal loading” (as found in the literature) in order to track the occurrence and the related evolution of research; (b) present a “linguistically modeled” definition of the same from the review of literature on the terms; and (c) propose conceptualized definition

Validation of Two Short Personality Inventories Using Self-Descriptions in Natural Language and Quantitative Semantics Test Theory

Background: If individual differences are relevant and prominent features of personality, then they are expected to be encoded in natural language, thus manifesting themselves in single words. Recently, the quantification of text data using advanced natural language processing techniques offers innovative opportunities to map people’s own words and narratives to their responses to self-reports. He

New stories for a more conscious, sustainable society: claiming authorship of the climate story

Sustainability philosophers claim that we are at an impasse of stories, finding ourselves in a blank chapter between the old and the new. The old story, characterized by separation, technological dominance and human superiority over nature, is unfolding in an ecological crisis giving space for a new narrative defined by inter-being, cooperation and balance. It has been put forward that this crisis

Framing sufficiency : Strategies of environmental non-governmental organisations towards reduced material consumption

The efficiency approach of moving towardssustainable consumption throughmainlytechnological solutions, which dominatesenvironmental policymaking, has overallfailed to reduce the adverse environmental impacts caused by unsustainable consumption patterns. Increasingly, it is recognized that efficiency needs to be coupled with sufficiency, which aims to reduce the absolute levels of consumption. Whil

The Practice Approach in Practice: : Lessons for Civil Society Organizations (CSOs) that work towards sustainable food consumption in Sweden

Recognizing the great potential of civil society organizations (CSOs) as drivers of socialchange, this study examines how CSOs’ work directed towards consumers—in this case, to make food consumption practices sustainable—could be analyzed and improved through insights in practice theory. This research scope adds to the sustainable consumption literature by shifting the lens from the rich body of s