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The glymphatic system is a waste clearance system in the brain that relies on the flow of cerebrospinal fluid (CSF) in astrocyte-bound perivascular spaces and has been implicated in the clearance of neurotoxic peptides such as amyloid-beta. Impaired glymphatic function exacerbates disease pathology in animal models of neurodegenerative diseases, such as Alzheimer's, which highlights the importance
The article begins with a presentation of the role of demonstration and pantomime in the evolution of teaching building on Gärdenfors and Högberg (2017). In comparison to different forms of animal communication, demonstration is voluntary, intentional, honest, and directed to one or a few individuals. Then the differences between demonstration and pantomime is analyzed. An important factor is that
Anthropogenic transformation of land globally is threatening water resources in terms of quality and availability. Managing water resources to ensure sustainable utilization is important for a semiarid country such as South Africa. Bayesian networks (BNs) are probabilistic graphical models that have been applied globally to a range of water resources management studies; however, there has been ver
Objective Describe demographical, social and psychological correlates of willingness to receive a COVID-19 vaccine. Setting Series of online surveys undertaken between March and October 2020. Participants A total of 25 separate national samples (matched to country population by age and sex) in 12 different countries were recruited through online panel providers (n=25 334). Primary outcome measures
Objective:The objective of this review was to assess associations between Individual Placement and Support (IPS), employment, and personal and clinical recovery among persons with severe mental illness at 18-month follow-up.Methods:A systematic literature search identified randomized controlled trials (RCTs) comparing IPS with services as usual. Outcomes were self-esteem, empowerment, quality of l
Sleep has evolved as a universal core function to allow for restorative biological processes. Detailed knowledge of metabolic changes necessary for the sleep state in the brain is missing. Herein, we have performed an in-depth metabolic analysis of four mouse brain regions and uncovered region-specific circadian variations. Metabolites linked to oxidative stress were altered during sleep including
BACKGROUND:Lack of mental health literacy among rehabilitation professionals and employers in the return-to-work of persons with mental health problems resulted in the development of a three-day group training program, the Support to Employers from rehabilitation Actors about Mental health (SEAM) intervention.OBJECTIVE:To evaluate the impact of SEAM on rehabilitation professionals’ knowledge and b
Land use is at the core of today’s complex sustainability challenges. Agricultural and environmental economics share a focus land and resource use but evolved in their own domains. Their specialized competencies can be complementary and thus strengthen policy analysis. We use structural topic modelling on more than 24,000 articles in the top agricultural economics and environmental economics journ
Exposure to complex mixtures of environmental contaminants may have severe consequences in free-living animals through the disruption of physiological mechanisms, reduced reproductive outputs and survival, thereby leading to population collapse. Contaminant analyses in fish have been used as a routine approach in studies of aquatic pollution. Located at the upper levels of the food webs, fish are
Streams, rivers and lakes across wide areas of the Northern hemisphere have been subject to an increase in water color over the last decades. This increase, also known as browning, is a result of rising dissolved organic matter (DOM) and iron (Fe) concentrations in the water. Over the years, browning has received ample attention due to its impact on the structure and function of freshwater ecosyst
The green economy with its aim to combine ecological and economic objectives has gained in both significance and political contestation in recent years. In this working paper for the NOWAGG project we revisit the literature on the green economy to understand its implications from a Nordic perspective. Our ambition is to improve the conceptualization of different approaches to green the economy by
This paper is an attempt to provide new perspectives on green energy defaults (GED) that promote the purchase of renewable energy electricity (REe) among consumers. We aim to complement existing studies and improve the understanding of GED, particularly when they are less, or unexpectedly, effective. To that end, we run a randomized controlled experiment and take the UK as a case study. We replica
En dag kommer Covid-19 pandemin att vara en del av vår historia, en del av vår individuella och kollektiva historia. Denna samhällskatastrof förändrade förutsättningarna för det sociala livet, däribland förutsättningarna för att bedriva undervisning på universitetet. I denna text är det studenternas röster som kommer fram. Så som alla andra högskoleutbildningar övergick Socialhögskolan till digita
Ptychography, a scanning coherent diffraction imaging method, can produce a high-resolution reconstruction of a sample and, at the same time, of the illuminating beam. The emergence of vacuum ultraviolet and X-ray free electron lasers (FELs) has brought sources with unprecedented characteristics that enable X-ray ptychography with highly intense and ultra-fast short-wavelength pulses. However, the
A novel and effective approach for determining mechanics and residual stress when turning a component with curved surfaces is presented in this paper. This predictive approach is based on a three-dimensional analytical model to study the distributed mechanics and residual stress caused by vary cutting condition during the machining process. The variation of uncut chip area in this process can be d
Objective: Termination in psychodynamic therapy (PDT) is a potentially conflictual and turbulent phase for patients, with a risk for increases in symptoms. However, few studies of PDT have assessed symptoms frequently enough during treatment to determine whether such setbacks are in fact common in PDT. Methods: In a doubly randomized clinical preference trial, 217 adults (female = 163; M age = 34.
The physics program of ultra-relativistic heavy-ion collisions at the Large Hadron Collider (LHC) and Relativistic Heavy-Ion Collider (RHIC) has brought a unique insight into the hot and dense QCD matter created in such collisions, the Quark-Gluon Plasma (QGP). Jet quenching, a collection of medium-induced modifications of the jets’ internal structure that occur through their development in dense
To reduce global HIV-1 incidence, there is a need to understand and disentangle HIV-1 transmission dynamics and to determine the geographic areas and populations that act as hubs or drivers of HIV-1 spread. In Sub-Saharan Africa (sSA), the region with the highest HIV-1 burden, information about such transmission dynamics is sparse. Phylogenetic inference is a powerful method for the study of HIV-1
Background Recently there has been increased interest in a possible association between mast cell activation (MCA) disorder and postural orthostatic tachycardia syndrome (POTS). This study examined the frequency with which symptoms and laboratory findings suggesting MCA disorder occurred in patients diagnosed with POTS. Methods and Results Data were obtained from patients in whom symptoms and orth
