The liver possesses a remarkable regenerative capacity based partly on the ability of hepatocytes to re-enter the cell cycle and divide to replace damaged cells. This capability is substantially reduced upon chronic damage, but it is not clear if this is a cause or consequence of liver disease. Here, we investigate whether blocking hepatocyte division using two different mouse models affects physi

Satellite cell proliferation is an essential step in proper skeletal muscle development and muscle regeneration. However, the mechanisms regulating satellite cell proliferation are relatively unknown compared to the knowledge associated with the differentiation of satellite cells. Moreover, it is still unclear whether overload muscle fiber hypertrophy is dependent on satellite cell proliferation.

Left ventricular (LV) stroke work (SW) is calculated from the pressure-volume (PV) loop. PV loops do not contain information on longitudinal and radial pumping, leaving their contributions to SW unknown. A conceptual framework is proposed to derive the longitudinal and radial contributions to SW, using ventricular force-length loops reflecting longitudinal and radial pumping. The aim of this study

Ecological diversity among diurnal birds of prey, or raptors, is highlighted regarding their sensory abilities. While raptors are believed to forage primarily using sight, the sensory demands of scavengers and predators differ, as reflected in their visual systems. Here, I have reviewed the visual specialisations of predatory and scavenging diurnal raptors, focusing on (1) the anatomy of the eye a

Primary ship waves generated by conventional marine vessels were investigated in the Furusund fairway located in the Stockholm archipelago, Sweden. Continuous water level measurements at two locations in the fairway were analyzed. In total, 466 such events were extracted during two months of measurements. The collected data were used to evaluate 13 existing predictive equations for drawdown height

The datafication of journalism creates new demands on journalists. The set of skills and the daily work in the newsroom have changed the profession where traditional values might still be present but are challenged by how data is received, constructed and analyzed. This impacts how journalism is being produced; data contributes to the reporting and provides opportunities on how to conduct research

The structure and function of proteins are strongly affected by the surrounding solvent water, for example through hydrogen bonds and the hydrophobic effect. These interactions depend not only on the position, but also on the orientation, of the water molecules around the protein. Therefore, it is often vital to know the detailed orientations of the surrounding ordered water molecules. Such inform

BACKGROUND: Serial assessment of phosphorus is currently recommended by the Kidney Disease: Improving Global Outcomes (KDIGO) guidelines, but its additional value versus a single measurement is uncertain. METHODS: We studied data from 17 414 HD patients in the Dialysis Outcomes and Practice Patterns Study, a prospective cohort study, and calculated the area under the curve (AUC) by multiplying the

The stacked multilevel (SML) klystron modulator topology has been suggested as an alternative to conventional pulse transformer-based topologies in an attempt to improve output pulse performance and reduce system size for long-pulse applications. In this topology, a power converter chain including a high-frequency transformer generates the output pulse in a pulse modulation/demodulation scheme, el

Lymphotoxin β-receptor (LTβR) signalling promotes lymphoid neogenesis and the development of tertiary lymphoid structures1,2, which are associated with severe chronic inflammatory diseases that span several organ systems3-6. How LTβR signalling drives chronic tissue damage particularly in the lung, the mechanism(s) that regulate this process, and whether LTβR blockade might be of therapeutic value

In order to make our production and consumption systems more sustainable, there is a need to further explore and support novel business models with higher sustainability potential. Use-oriented product-service systems (u-PSS) are considered a promising alternative to traditional ownership-based business models, as they may result in lower environmental impacts. The presence of u-PSS in consumer go

Evaluations hold the potential to support decision-making so that current global challenges related to climate and energy can be addressed; however, as the challenges are becoming increasingly large and complex, new and transformative evaluation approaches are called for. Such transformative evaluation in turn builds on an extended and more deliberate use of evaluations. This study focuses on the

Osteoporosis often leads to fragility fractures of the hip, resulting in impaired quality of life and increased mortality. Augmenting the proximal femur could be an attractive option for prevention of fracture or fixation device failure. We describe a tissue engineering based strategy to enhance long-term bone formation in the femoral neck of osteoporotic rats by locally delivering bioactive molec

In natural behavior, we fluidly change from one type of activity to another in a sequence of motor actions. Corticostriatal circuits are thought to have a particularly important role in the construction of action sequences, but neuronal coding of a sequential behavior consisting of different motor programs has not been investigated at the circuit level in corticostriatal networks, making the exact

Neglected tropical diseases affect most of the underprivileged populations in tropical countries. Among these are chagas and leishmaniasis, present mainly in South and Central America, Africa and East Asia. Current treatments are long and have severe adverse effects, therefore there is a strong need to develop alternatives. In this study, we base our research on the plant metabolite pulchrol, a na

The Lund-jet plane has recently been proposed as a powerful jet substructure tool with a broad range of applications. In this paper, we provide an all-order single logarithmic calculation of the primary Lund-plane density in Quantum Chromodynamics, including contributions from the running of the coupling, collinear effects for the leading parton, and soft logarithms that account for large-angle an

PURPOSE: To explore the frequency and outcomes of cataract surgery in eyes with previous vitrectomy. SETTING: Fifteen European countries. DESIGN: Retrospective cross-sectional register-based study. METHODS: The European Registry of Quality Outcomes of Cataract and Refractive Surgery (EUREQUO) contains data on baseline characteristics, surgery, and follow-up for cataract surgeries. Previous vitrect

Collimated sprays of paticle, known as jets,are abundantly produced in high-energy proton-proton (pp) collisions, and are predicted by many theories of physics beyond the Standard Model. This thesis reports first on the calibration of jets with focus on the data-driven in situ calibration. Two searches for new physics phenomena in events with jets in the final state are then presented. The analyse