Purpose: To examine prevalence and predictors of neurocognitive outcomes, social attainment, emotional distress, and health-related quality of life (HRQOL) in long-term survivors of pediatric Wilms tumor (WT). Methods: One hundred fifty-eight WT survivors (59% female; mean [SD] age 33 [9.1] years; time since diagnosis 29 [9.1] years) and 354 community controls (55.6% female; 35 [10.2] years) compl

In the field of church history, this article is a study of the Reformation period on a specific topic, namely, asceticism, from an uncommon perspective. One of the most well-known Reformation treatises, Martin Luther’s On the Freedom of a Christian, is read in conversation with an earlier ascetic wri¬ting, Maximus Confessor’s The Ascetic Life, and then compared to an under¬stu¬died debate from the

Лише останніми роками інтелектуальна історія євгеніки в Східній Європі стала предметом систематичного академічного дослідження. Проте євгенічна думка в міжвоєнній українській радикально-націоналістичній традиції залишається історіографічною terra incognito. Ця стаття — перша спроба дослідження євгеніки й расової антропології в українській націоналістичній думці 1930—1960-х років. Яку роль відіграв

Praktisk epidemiologi för medicin, vård och folkhälsa ger dig nödvändiga redskap för att kunna läsa, förstå och kritiskt granska epidemiologiska forskningsresultat. Den är också skriven för dig som planerar att genomföra ett eget projekt eller bedriva epidemiologisk forskning.Framställningen är problemorienterad: viktiga begrepp och grundläggande metoder introduceras i direkt anslutning till epide

Mounting evidence indicates that the presence of cardiovascular disease (CVD) and risk factors elevates the incidence of cognitive impairment (CI) and dementia. CVD and associated decline in cardiovascular function can impair cerebral blood flow (CBF) regulation, leading to the disruption of oxygen and nutrient supply in the brain where limited intracellular energy storage capacity critically depe

Astrocytes support normal brain function, but may also contribute to neurodegeneration when they become reactive under pathological conditions such as stroke. However, the molecular underpinnings of this context‐dependent interplay between beneficial and detrimental properties in reactive astrogliosis have remained incompletely understood. Therefore, using the RiboTag technique, we immunopurified

NG2 cells, a fourth glial cell type in the adult mammalian central nervous system, produce oligodendrocytes in the healthy nervous tissue, and display wide differentiation potential under pathological conditions, where they could give rise to reactive astrocytes. The factors that control the differentiation of NG2 cells after focal cerebral ischemia (FCI) are largely unknown. Here, we used transge

Alzheimer’s disease (AD) is one of the most serious human, medical, and socioeconomic burdens. Here we tested the hypothesis that a rat model of AD (Samaritan; Taconic Pharmaceuticals, USA) based on the application of amyloid beta42 (Abeta42) and the pro-oxidative substances ferrous sulfate heptahydrate and L-buthionine-(S, R)-sulfoximine, will exhibit cognitive deficits and disruption of the glut

This thesis contains two studies focusing on motivation in learning and teaching French as a foreign language in Sweden. In the first study, the effect of three specifically designed pedagogical activities on learners’ Ideal French Self (IFrS) and Intended Effort (IE) was examined in a group of 15-year-old Swedish pupils. No significant difference could be found between the two intervention classe

EU-rätten har på flera områden lett till förändringar av den svenska lagstiftningen, men samtidigt ger EU-rätten stort och outnyttjat handlingsutrymme för de enskilda nationerna. Exempel på sådana utrymmen är bostadspolitiken och regelverket för offentlig upphandling. Ett klarläggande av vilket handlingsutrymme som faktiskt föreligger är av stor betydelse för analysen av vilket utrymme som finns a

The European Union (EU) has been entrusted with rather weak powers as regards industrial policy. On top of this, its Member States are prevented from pursuing a national industrial policy with monetary elements as this may distort competition within the EU internal market. At the same time, European companies compete in the global market with state-supported companies from other economically stron

Every cell is surrounded by a thin plasma membrane, protecting it from its surrounding. Specialized protein channels and transporters are embedded in this membrane, ensuring selective transport of molecules in and out of the cells. To maintain optimal hydration, water channels called aquaporins (AQPs) are present in every cell of our body. Thirteen isoforms of aquaporins exist in humans of which t