Popular Abstract in Swedish Varje dag produceras miljardtals nya blodceller, vilka exempelvis har som uppgift att transportera runt syre och försvara kroppen mot olika invaderande bakterier och virus. Dessa olika blodkomponenter har sitt ursprung i sällsynta blodbildande stamceller som återfinns i benmärgen. Dessa är så kallade vävnadsspecifika stamceller och har både förmågan att återbilda sig sjBlood cell formation, or hematopoiesis, is maintained by rare hematopoietic stem cells (HSCs) residing in the bone marrow (BM). HSCs may self-renew (the process whereby HSCs replicate to produce new HSCs) to preserve their own numbers, as well as initiate a highly coordinated hierarchical differentiation process that results in the production of mature effector blood cells. Aging is characterized

The rapid technological developments of the new millennium have presented exciting challenges to the well-established field of cultural memory studies. Today, it behoves us analyse the ways in which digital systems make it possible to store, copy, and decentralize memories, making them increasingly accessible on the Internet. The digital media offer gateways to the past that are more comprehensive

Until now inscriptions have confirmed that the quarries of Gebel el Silsila East were in use until the time of Emperor Tiberius, but recent findings indicate that the quarrying process continued for at least another two generations. In one of the many smaller quarries three men carved their name repeatedly on the quarry walls, and dated their visits to a four year period, between the sixth and ten

Background Patients who have suffered from tuberculosis are at risk of respiratory failure with hypercapnea from chest wall deformity and hypoxia from pulmonary sequelae. The combination of hypercapnea and hypoxia justifies both mechanical ventilation and oxygen therapy as treatment options. We aimed to study which treatment mode is associated with the best survival in patients with the combinatio

The article is an analysis of the Okupatsioonide Museum, The Museum of the Occupations, in Tallinn, Estonia. The analysis deals both with the content of the exhibition as well as well as the monuments of former Communists in its basement, It alse deals with "the power of place", the location of the museum and its importance in Tallinn´s "cityscape".

A constitutive model is presented, considering grain size refinement through continuous dynamic recrystallization together with an evolving dislocation density. The grain refinement is allowed to influence both the evolution of the dislocation density and the rate dependence of the material. The model is calibrated against experimental data on aluminum and numerical simulations of equal channel an

Background There are plausible mechanisms for how dietary docosahexaenoic acid (DHA), an n-3 polyunsaturated fatty acid, could prevent Crohn's disease (CD). Aim To conduct a prospective study to investigate the association between increased intake of DHA and risk of CD. Methods Overall, 229702 participants were recruited from nine European centres between 1991 and 1998. At recruitment, dietary int

Open innovation is an emerging innovation paradigm that can greatly accelerate technical knowledge innovation in software companies. The increasing importance and density of software in today’s products and services puts extensive pressure on excelling the discovery, description and execution of innovation. Despite that, software engineering literature lacks methods, tools and frameworks for full

Recently, the single nucleotide polymorphism (SNP) identified as rs1260326, in the glucokinase regulatory protein (GCKR), was associated with hypertriglyceridemia in adults. Because accumulation of triglycerides in hepatocytes represents the hallmark of steatosis, we aimed to investigate whether this variant might be associated with fatty liver (hepatic fat content, HFF%). Moreover, because recent

In this paper a fully coupled thermomechanical two-dimensional simulation model for orthogonal cutting is presented. The model is based on the arbitrary Lagrangian-Eulerian formulation with the remeshing technique. The material model used for the workpiece material includes Johnson-Cook plasticity, and as the chip separation criterion the Johnson-Cook damage law is employed. The different friction

In this paper we construct ternary q-Virasoro-Witt algebras which q-deform the ternary Virasoro-Witt algebras constructed by Curtright, Fairlie and Zachos using su(1, 1) enveloping algebra techniques. The ternary Virasoro-Witt algebras constructed by Curtright, Fairlie and Zachos depend on a parameter and are not Nambu-Lie algebras for all but finitely many values of this parameter. For the parame

The clover seed weevils Apion fulvipes Geoffroy, 1785 and Apion trifolii L., 1768 (Coleoptera: Apionidae) cause major losses to seed production of white clover (Trifolium repens L.) and red clover (Trifolium pratense L.), respectively. Clover is important as animal forage and an alternative to inorganic fertilizers. Because clover is mainly pollinated by bees, the use of insecticides in management

Background: While the benefits or otherwise of early hip fracture repair is a long-running controversy with studies showing contradictory results, this practice is being adopted as a quality indicator in several health care organizations. The aim of this study is to analyze the association between early hip fracture repair and in-hospital mortality in elderly people attending public hospitals in t

Grating interferometer based imaging with X-rays and neutrons has proven to hold huge potential for applications in key research fields conveying biology and medicine as well as engineering and magnetism, respectively. The thereby amenable dark-field imaging modality implied the promise to access structural information beyond reach of direct spatial resolution. However, only here a yet missing app

It is well known that adoptive transfer of donor-derived tolerogenic dendritic cells (DC) helps to reduce acute allograft rejection. However, this method cannot effectively prevent grafts from infiltration of inflammatory cells and fibrosis, and thus has minimal effect on chronic allograft rejection. In this study, we used mitomycin C (MMC) to generate tolerogenic DC and demonstrated that donor (B

Välfärdstjänsterna har antagit formen av marknadsbaserade tjänster på grund av en ökad marknadsorientering. I artikeln analyseras vad valfrihet gällande välfärdstjänster kan innebära för medborgaren i olika socioekonomiska positioner genom att fokusera faktorer som kan begränsa valmöjligheter. En slutsats är att både resursstarka och resurssvaga har begränsade valmöjligheter. En annan slutsats är