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Three-dimensional spatial mapping of the human hematopoietic microenvironment in healthy and diseased bone marrow

The bone marrow hematopoietic microenvironment (HME) plays a pivotal role in regulating normal and diseased hematopoiesis. However, the spatial organization of the human HME has not been thoroughly investigated yet. Therefore, we developed a three-dimensional (3D) immunofluorescence model to analyze changes in the cellular architecture in control and diseased bone marrows (BMs). BM biopsies from p

Risk Factors for Postoperative Complications Following Resection of Colorectal Liver Metastases and the Impact on Long-Term Survival : A Population-Based National Cohort Study

Background: Postoperative complications (POCs) following resection of colorectal liver metastases (CRLM) are common. The objective of this study was to evaluate risk factors for developing complications and their impact on survival considering prognostic factors of the primary tumor, metastatic pattern and treatment in a well-defined national cohort. Methods: Patients treated with resection for CR

A graph autoencoder network to measure the geometric similarity of drainage networks in scaling transformation

Similarity measurement has been a prevailing research topic in geographic information science. Geometric similarity measurement in scaling transformation (GSM_ST) is critical to ensure spatial data quality while balancing detailed information with distinctive features. However, GSM_ST is an uncertain problem due to subjective spatial cognition, global and local concerns, and geometric complexity.

Mismatch repair deficiency testing in Lynch syndrome-associated urothelial tumors

Introduction: Lynch syndrome-associated cancer develops due to germline pathogenic variants in one of the mismatch repair (MMR) genes, MLH1, MSH2, MSH6 or PMS2. Somatic second hits in tumors cause MMR deficiency, testing for which is used to screen for Lynch syndrome in colorectal cancer and to guide selection for immunotherapy. Both MMR protein immunohistochemistry and microsatellite instability

Complexities of trust building through sociomaterial arrangements of peer-to-peer platforms

Trading on peer-to-peer tourist accommodation platforms requires a sufficient level of trust between individual consumers and service providers. This is often achieved by using mutual consumer–provider evaluations, which are perceived as a trustworthy resource for information about upcoming stays. A variety of mechanisms and metrics are used to facilitate trust building on platforms; however, trus

Perceptions of the appropriate response to norm violation in 57 societies

Norm enforcement may be important for resolving conflicts and promoting cooperation. However, little is known about how preferred responses to norm violations vary across cultures and across domains. In a preregistered study of 57 countries (using convenience samples of 22,863 students and non-students), we measured perceptions of the appropriateness of various responses to a violation of a cooper

Symbioses shape feeding niches and diversification across insects

For over 300 million years, insects have relied on symbiotic microbes for nutrition and defence. However, it is unclear whether specific ecological conditions have repeatedly favoured the evolution of symbioses, and how this has influenced insect diversification. Here, using data on 1,850 microbe–insect symbioses across 402 insect families, we found that symbionts have allowed insects to specializ

Quality of life and functional status after pulmonary endarterectomy for chronic thromboembolic pulmonary hypertension : A Swedish single-center study

Little is known about long-term quality of life (QOL) and functional status after pulmonary endarterectomy (PEA) for chronic thromboembolic pulmonary hypertension (CTEPH). We investigated QOL and functional status late after PEA. All patients who underwent PEA for CTEPH 1993–2020 at one Swedish center were included. Baseline characteristics and data from right heart catheterization, 6-min walk tes

Lingering landscapes: an examination of the heterogeneous remains of welfare planning

This paper explores how landscape can be used as a lens to understand lingering as a geographical concept. Following the European Landscape Convention, landscape is defined as “an area, as perceived by people, whose character is the result of the action and interaction of natural and/or human factors”. Thus, landscape assembles practices, perceptions and natural processes in an a-modern manner; th

Effects of nonvanishing net charge on balance functions and their integrals

We investigate the impact of nonvanishing net charge in collision systems on measurements of balance functions and their integrals. We show that the nominal balance function definition yields integrals that deviate from unity because of the nonvanishing net charge. However, the integral of unified balance functions is shown to appropriately converge to unity when measured in a sufficiently wide ex

TP53-mediated clonal hematopoiesis confers increased risk for incident atherosclerotic disease

Somatic mutations in blood indicative of clonal hematopoiesis of indeterminate potential (CHIP) are associated with an increased risk of hematologic malignancy, coronary artery disease and all-cause mortality. Here we analyze the relation between CHIP status and incident peripheral artery disease (PAD) and atherosclerosis, using whole-exome sequencing and clinical data from the UK Biobank and the

Information-to-work conversion in single-molecule experiments : From discrete to continuous feedback

We theoretically investigate the extractable work in single molecule unfolding-folding experiments with applied feedback. Using a simple two-state model, we obtain a description of the full work distribution from discrete to continuous feedback. The effect of the feedback is captured by a detailed fluctuation theorem, accounting for the information aquired. We find analytical expressions for the a

Pharmacology of the Bladder and Emerging Treatments

The nervous mechanisms for bladder emptying and urine storage involve a complex pattern of afferent and efferent signaling in parasympathetic, sympathetic, and somatic nerves. During voiding, contraction of the detrusor muscle is preceded by a relaxation of the outlet region, thereby facilitating the bladder emptying. Kim et al. found that 14 of 31 patients with overactive bladder (OAB) and noctur

Effect of Conventional and Ultrahigh Dose Rate FLASH Irradiations on Preclinical Tumor Models : A Systematic Analysis

Purpose: Compared with conventional dose rate irradiation (CONV), ultrahigh dose rate irradiation (UHDR) has shown superior normal tissue sparing. However, a clinically relevant widening of the therapeutic window by UHDR, termed “FLASH effect”, also depends on the tumor toxicity obtained by UHDR. Based on a combined analysis of published literature, the current study examined the hypothesis of tum

Image quality of spectral brain computed tomography angiography using halved dose of iodine contrast medium

Purpose: Reduction in iodinated contrast medium (CM) dose is highly motivated. Our aim was to evaluate if a 50% reduction of CM, while preserving image quality, is possible in brain CT angiography (CTA) using virtual monoenergetic images (VMI) on spectral CT. As a secondary aim, we evaluated if VMI can salvage examinations with suboptimal CM timing. Methods: Consecutive patients older than 18 year

Tumoral parkinsonism—Parkinsonism secondary to brain tumors, paraneoplastic syndromes, intracranial malformations, or oncological intervention, and the effect of dopaminergic treatment

Introduction: Secondary tumoral parkinsonism is a rare phenomenon that develops as a direct or indirect result of brain neoplasms or related conditions. Objectives: The first objective was to explore to what extent brain neoplasms, cavernomas, cysts, paraneoplastic syndromes (PNSs), and oncological treatment methods cause parkinsonism. The second objective was to investigate the effect of dopamine