Atypical hemolytic uremic syndrome (aHUS) emerged during the last decade as a disease largely of complement dysregulation. This advance facilitated the development of novel, rational treatment options targeting terminal complement activation, e.g., using an anti-C5 antibody (eculizumab). We review treatment and patient management issues related to this therapeutic approach. We present consensus cl

The decay chain of Fm-246 has been investigated employing the SHIP separator at GSI Darmstadt. The Fm-246 nuclei were produced via the Ar-40(Pb-208, 2n)Fm-246 fusion-evaporation reaction. Improved values of the half-life, T-1/2 = 1.54(4) s, and of the spontaneous fission branching ratio, b(SF) = 0.068(6), of Fm-246 were obtained. The beta(+)/electron capture branching ratio, b(EC) = 0.39(3), of Cf

This Letter reports a measurement of the high-mass Drell-Yan differential cross-section in proton-proton collisions at a centre-of-mass energy of 7 TeV at the LHC. Based on an integrated luminosity of 4.9 fb(-1), the differential cross-section in the Z/gamma* -> e(+)e(-) channel is measured with the ATLAS detector as a function of the invariant mass, m(ee), in the range 116 < m(ee) < 1500 GeV, for

Popular Abstract in Swedish Bröstcancer är den vanligaste cancerdiagnosen hos kvinnor, och under år 2011 fick över 8000 svenska kvinnor denna diagnos. Termen bröstcancer är egentligen ett samlingsnamn för alla de olika typer av cancer som kan uppstå i bröstet. En del typer av bröstcancer har en bra prognos medan andra trots aggressiv behandling alltjämt har en dålig prognos. Cancer är en sjukdom dBreast cancer is a heterogenous disease which can be divided in subgroups of distinct biology with disparate prognosis and response to treatment. The overall aim of this thesis was to delineate subgroup specific behaviour in breast cancer cells with focus on proliferation, migration and stem-like cell activity. In addition, we have studied the functional retinoblastoma tumour suppressor (RB) prote

Background: Earlier analyses within the EPIC study showed that dietary fibre intake was inversely associated with colorectal cancer risk, but results from some large cohort studies do not support this finding. We explored whether the association remained after longer follow-up with a near threefold increase in colorectal cancer cases, and if the association varied by gender and tumour location. Me

Objectives High-risk human papillomavirus (hrHPV) is the primary cause of cervical cancer. As Chlamydia trachomatis is also linked to cervical cancer, its role as a potential co-factor in the development of cervical intraepithelial neoplasia (CIN) grade 2 or higher was examined. Methods The placebo arms of two large, multinational, clinical trials of an HPV6/11/16/18 vaccine were combined. A total

Objective: To determine the validity of 15 standardized instruments frequently used to measure the outcome of chronic arthritis treatment. Methods: Analyses were performed on data collected at a rehabilitation programme (n=216). The outcome measures evaluated were health-related quality of life, global health, pain, physical function and aerobic capacity. The instrument items were linked to the In

OBJECTIVES: Questions regarding the cell source and mechanisms in the initiation and progression of prostate cancer are today still open for debate. Indeed, our knowledge regarding prostate cell regulation, self-renewal, and cytodifferentiation is presently rather limited. In this study, we investigated these processes in the normal adult human prostate. METHODS: Dynamic expression patterns in pro

Selective immunoglobulin A deficiency is the most common primary immunodeficiency disorder that is strongly overrepresented among patients with celiac disease (CD). IgG antibodies against tissue transglutaminase (tTG) and deamidated gliadin peptides (DGP) serve as serological markers for CD in IgA deficient individuals, although the diagnostic value remains uncertain. The aim of this study was to

The scholarly literature on innovation was for a long time not very voluminous. But as shown in the paper, this is now rapidly changing. New journals, professional associations and organizational units within universities focusing on innovation have also been formed. This paper explores the cognitive and organizational characteristics of this emerging field of social science and considers its pros

Optical and micro-physical features of aerosol are reported using Skyradiometer (POM-01L, Prede, Japan) observations taken from a high-altitude station Merak, located in north-eastern Ladakh of the western trans-Himalayas region during January 2011 to December 2013. The observed daily mean aerosol optical depth (AOD, at 500 nm) at the site varied from 0.01 to 0.14. However, 75 % of the observed AO

Since the early days of satellite remote sensing in the 1950’s, accessibility, quality, and scope of remote sensing image data has been continuously improving, making it a rich data source with a wide range of applications. Today, the use of remote sensing techniques and data is commonplace within many disciplines in the natural sciences. Although there are quite a few examples of remote sensing t

OBJECTIVES: Between 1984 and 1996, Sweden experienced an "epidemic" of clinical celiac disease in children

The phylogeographical evolution and the consequent changing distribution and diversity of rhynchonelliform brachiopods through the Ordovician are linked to the dynamic palaeogeography of the period. The Early Ordovician (Tremadocian and Floian) is characterized by globally low-diversity faunas with local biodiversity epicentres, notably on the South China Palaeoplate; low-latitude porambonitoid-do

Aktuell status för dagvattenhantering i grannstäderna Köpenhamn och Malmö studerades med avseende på befintliga åtgärder och genomförda systemen i de båda städerna. Tillämpning av blå-gröna lösningar i de yttre delarna av Malmö började på 1990-talet och följaktligen är samarbete mellan olika avdelningar inom kommunen mer strukturerat i Malmö medan processen i Köpenhamn fortfarande är baserad på trThe current status of storm-water management in the neighbor cities of Copenhagen and Malmö was studied with respect to present measures and the implemented systems in both cities. Application of blue-green solutions in the outer parts of Malmö started in the 1990s; hence collaboration between different departments in the municipality is more structured in the city of Malmö while in Copenhagen the

Flight directions and routes of migrating birds are determined by the birds' compass orientation, but also by effects of wind, social influence, responses to topography and landmarks, and to navigation cues. We investigated the orientation and routes taken by arctic shorebirds during autumn migration in southern Sweden at three different sites situated within a distance of 200 km from each other,

This paper provides three short proofs of the classical Gibbard–Satterthwaite theorem. The theorem is first proved in the case with only two voters. The general case follows then from an induction argument over the number of voters. The proof of the theorem is further simplified when the voting rule is neutral. The simple arguments in the proofs may be especially useful in classroom situations.

Wilms Tumor suppressor protein (WT1) is a transcription factor that is involved in a variety of developmental functions during organ development. It is also implicated in the pathology of several different cancer forms. The protein contains four C(2)H(2)-type zinc fingers and it specifically binds GC-rich sequences in the promoter regions of its target genes, which are either up or down regulated.