BACKGROUND: Although colorectal cancer (CRC) is generally not considered to be a hormone-dependent malignancy, several sex-related differences in incidence, molecular characteristics and survival have been reported. Epidemiological studies have consistently shown that increased exposure to female sex hormones is associated with a lower risk of CRC in women, and cyclin D1, an important downstream e

The purpose of this study was to determine the incidence of aerococcal bacteraemia in the MALDI-TOF MS-era, to describe the clinical presentation and to determine the MIC values of aerococci for ten antibiotics. Aerococci in blood cultures were identified through searches in the laboratory database for the years 2012-2014. MALDI-TOF MS, sequencing of the 16S rRNA gene and a PYR test were used for

We present an assessment of the barium abundance ratios for red giant member stars in the faint Hercules dwarf spheroidal (dSph) galaxy. Our results are drawn from intermediate-resolution FLAMES/GIRAFFE spectra around the Ba II 6141.71 angstrom absorption line at low signal-to-noise ratios. For three brighter stars we were able to gain estimates from direct equivalent-width measurements, while for

Background: Endothelial dysfunction plays a central role in atherosclerotic progression and cardiovascular complications of type 2 diabetes mellitus (T2DM). Given the role of nitric oxide in the vascular system, we aimed to test hypotheses of synergy between the common endothelial nitric oxide synthase (eNOS) Asp(298) allele and T2DM in predisposing to acute myocardial infarction (AMI). Methods: I

The use of longitudinal historical micro-level demographic data for research presents many challenges. The Intermediate Data Structure (IDS) was developed to try to solve some of these challenges by facilitating the storing and sharing of such data. This article proposes an extension to the IDS, which allows the standardization and storage of constructed variables. It also describes how to produce

Evidence is accumulating that the pathogenesis of many diseases is triggered by inappropriate inflammatory responses. These serious complications may occur when the tightly regulated inflammatory network is out of balance and it is now clear that this can eventually cause substantial harm to own cells and tissues. Successful infectious agents have evolved an enormous repertoire of modulatory mecha

Since type 1 diabetes mellitus (T1DM) patients with nephropathy (DN+) are insulin-resistant, we aimed to identify (new) potential molecular sites involved in the alterations of glucose metabolism in these patients. We examined the expression of glycolytic enzymes in cultured fibroblasts from T1DM(DN+) patients as compared to those from T1DM patients without nephropathy (DN-) and from controls. Pyr

We tested how dispersal capacity, host plant specificity and reproductive rate influenced the effects of farming system and landscape composition on butterfly species richness and abundance. In no case did variation in these traits explain species responses to organic farming, indicating that all species benefit equally. In contrast, butterflies with high mobility and reproductive rate were dispro

The neuropsychological network is a complex structure. To identify processes location and network capacity the brain imaging techniques together and in combination with other neuropsychological techniques and the expanding of well elaborated designs provide us with a multidimensional understanding, and contributes to the understanding of each illicit drug's character, which is of importance in des

The feasibility of applying laser-induced phosphorescence in a combustion environment was shown by testing the consistency of the emission-temperature relations of thermographic phosphor particles (YAG:Dy). The relations were calibrated before and after the phosphor particles had passed a flame front. The calibrations were performed in air and in pure oxygen. The emission-temperature relation prev

A cochlear implant (CI) is a device that provides individuals with severe to profound hearing impairment (SPHI) with auditory stimulation, which makes it possible for them to develop skills related to spoken communication. We have little knowledge about how hearing with a CI influences cognitive and communicative development and there is a need for development of methods for assessment. The genera

Reduced, stoichiometric and oxidized TiO2(110) surfaces have been compared using valence photoelectron spectroscopy. The results show that the intensity from the band-gap state carries contributions from both oxygen surface vacancies and residual Ti interstitials, present after the sample cleaning procedure. The density of Ti interstitials was found to be 0.05 +/- 0.02 monlayers (ML), while the de

Purpose – The purpose of this study is to understand the identity of the Nobel Prize as a corporate heritage brand and its management challenges. Design/methodology/approach – An in-depth case study analysed within a heritage brand model and a corporate brand identity framework. Findings – The Nobel Prize is a corporate heritage brand – one whose value proposition is based on heritage – in this