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High-Density Lipoprotein–Associated Apolipoprotein M Limits Endothelial Inflammation by Delivering Sphingosine-1-Phosphate to the Sphingosine-1-Phosphate Receptor 1

OBJECTIVE—: Plasma high-density lipoproteins (HDL) are potent antiatherogenic and anti-inflammatory particles. However, HDL particles are highly heterogenic in composition, and different HDL-mediated functions can be ascribed to different subclasses of HDL. Only a small HDL population contains apolipoprotein M (ApoM), which is the main plasma carrier of the bioactive lipid mediator sphingosine-1-p

Remaining divides : Access to and use of ICTs among elderly citizens

The ambition to make all kinds of societal services, public as well as commercial ones, more effective and accessible via online applications is reoccurring all over the western world. To a large extent, such ambitions hold the promise to make citizens’ everyday lives easier, but they are, however, also problematic in that they presuppose a number of important prerequisites. They presuppose widesp

Replication of the Association of BDNF and MC4R Variants With Dietary Intake in the Diabetes Prevention Program

OBJECTIVES: Genomewide association studies (GWAS) have identified consistent associations with obesity, with a number of studies implicating eating behavior as a primary mechanism. Few studies have replicated genetic associations with dietary intake. This study evaluates the association between obesity susceptibility loci and dietary intake. METHODS: Data were obtained as part of the Diabetes Prev

Alcohols at the aqueous surface : Chain length and isomer effects

Surface-active organic molecules at the liquid-vapor interface are of great importance in atmospheric science. Therefore, we studied the surface behavior of alcohol isomers with different chain lengths (C4-C6) in aqueous solution with surface- and chemically sensitive X-ray photoelectron spectroscopy (XPS), which reveals information about the surface structure on a molecular level. Gibbs free ener

Prevalence of unknown and untreated arrhythmias in an older outpatient population screened by wireless long-term recording ECG

Purpose: With longer life expectancies, the prevalence of arrhythmias is increasing; thus, there is a need for new methods to screen the older outpatient population. This population-based study describes the prevalence of arrhythmias in 200 outpatients aged ≥66 years. We also investigated the feasibility of wireless long-term recording (LTR) using the ECG-BodyKom®. Methods: Two hundred elderly per

Clinical prediction of suicide and undetermined death : A pseudo-prospective clinical and medico-legal study of substance abusers

This study examines aspects of prediction of suicide and death of undetermined intent. We investigated all consecutive, autopsied patients between 1993 and 1997 who had been in contact with the Addiction Centre in Malmö from 1968 onwards. The staff was asked, shortly after autopsy but before they knew of the manner of death, if they thought the patient had committed suicide. The case records were

Antenatal management in fetal and neonatal alloimmune thrombocytopenia : A systematic review

Several strategies can be used to manage fetal or neonatal alloimmune thrombocytopenia (FNAIT) in subsequent pregnancies. Serial fetal blood sampling (FBS) and intrauterine platelet transfusions (IUPT), as well as weekly maternal IV immunoglobulin infusion (IVIG), with or without additional corticosteroid therapy, are common options, but optimal management has not been determined. The aim of this

Entrepreneurial learning and innovation : The critical role of team-level learning for the evolution of innovation capabilities in technology-based ventures

PurposeThe purpose of this paper is to develop a conceptual model that explains how learning processes at the team level connect with individual and organizational levels of learning in technology-based ventures, thereby influencing the evolution of innovation capabilities in the entrepreneurial process.Design/methodology/approachThe 4I organizational learning framework is used as an overarching tPurposeThe purpose of this paper is to develop a conceptual model that explains how learning processes at the team level connect with individual and organizational levels of learning in technology-based ventures, thereby influencing the evolution of innovation capabilities in the entrepreneurial process.Design/methodology/approachThe 4I organizational learning framework is used as an overarching t

Praktiskt konstitutionellt dömande : En handbok

Fri- och rättigheterna enligt svenska grundlagar samt Europakonventionen och EU:s rättighetsstadga har tolkats i en hel del domstolsavgöranden. I denna bok ges en överblick över den rättspraxis som finns. Generella frågor om fri- och rättigheternas förhållande till övriga typer av regler tas upp, liksom den praxis som finns inom olika delar av fri- och rättighetsskyddet: Domstolsprocessens funktio

GIS-based Maps and Area Estimates of Northern Hemisphere Permafrost Extent during the Last Glacial Maximum

This study presents GIS-based estimates of permafrost extent in the northern circumpolar region during the Last Glacial Maximum (LGM), based on a review of previously published maps and compilations of field evidence in the form of ice-wedge pseudomorphs and relict sand wedges. We focus on field evidence localities in areas thought to have been located along the past southern border of permafrost.

Autophagy dysfunction and regulatory cystatin C in macrophage death of atherosclerosis

Autophagy dysfunction in mouse atherosclerosis models has been associated with increased lipid accumulation, apoptosis and inflammation. Expression of cystatin C (CysC) is decreased in human atheroma, and CysC deficiency enhances atherosclerosis in mice. Here, we first investigated the association of autophagy and CysC expression levels with atheroma plaque severity in human atherosclerotic lesion

Central limit theorems for functionals of large dimensional sample covariance matrix and mean vector in matrix-variate skewed model

In this paper we consider the asymptotic distributions of functionals of the sample covariance matrix and the sample mean vector obtained under the assumption that the matrix of observations has a matrix variate general skew normal distribution. The central limit theorem is derived for the product of the sample covariance matrix and the sample mean vector. Moreover, we consider the product of an i

Spatial size of waves

A method of measuring three-dimensional spatial wave size is proposed and statistical distributions of the size characteristics are derived in explicit integral forms for Gaussian sea surfaces. New definitions of wave characteristics such as the crest-height, the length, the size and the wave front location are provided in fully dimensional context. The joint statistical distributions of these wav

Cerebrospinal fluid Alzheimer's disease biomarkers across the spectrum of lewy body diseases : Results from a large multicenter cohort

Background: Concomitant Alzheimer's disease (AD) pathology is observed in Lewy body diseases (LBD), but the clinical impact is unknown. Only a few biomarker studies in LBD exist and have included small cohorts from single centers. Objective: We aimed to evaluate the prevalence of abnormal cerebrospinal fluid (CSF) AD biomarkers across the spectrum of LBD in a large multicenter cohort and to assess

Sirenophila ovis-atra a new species of maritime teloschistaceae from the southern hemisphere

A new species, Sirenophila ovis-atra is described from maritime rocks of southern Patagonia, the Falkland Islands and Macquarie Island, where it grows in the upper part of the black ‘Verrucaria-zone’, most often on members of the genus Hydropunctaria. It is so far the only known species of Sirenophila in South America, a genus that is particularly prominent on the coasts of Australia.

A sex pheromone receptor in the Hessian fly Mayetiola destructor (Diptera, Cecidomyiidae)

The Hessian fly, Mayetiola destructor Say (Diptera, Cecidomyiidae), is a pest of wheat and belongs to a group of gall-inducing herbivores. This species has a unique life history and several ecological features that differentiate it from other Diptera such as Drosophila melanogaster and blood-feeding mosquitoes. These features include a short, non-feeding adult life stage (1–2 days) and the u

Towards a new conditionality? : The convergence of international development, nation brands and soft power in the British National Security Strategy

Nation brands are intended to act as vehicles for economic development. However, the role of the nation brands of developed countries in shaping the economic development of developing countries has not been explored to the same degree. Using the example of Britain’s 2010 National Security Strategy, this article argues that the two-decade long decline in conditional aid has been superseded by effor