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Gendered Self-Views Across 62 Countries: A Test of Competing Models

Social role theory posits that binary gender gaps in agency and communion should be larger in less egalitarian countries, reflecting these countries’ more pronounced sex-based power divisions. Conversely, evolutionary and self-construal theorists suggest that gender gaps in agency and communion should be larger in more egalitarian countries, reflecting the greater autonomy support and flexible sel

Characterization of Patients in the International Severe Asthma Registry with High Steroid Exposure Who Did or Did Not Initiate Biologic Therapy

Background: Many severe asthma patients with high oral corticosteroid exposure (HOCS) often do not initiate biologics despite being eligible. This study aimed to compare the characteristics of severe asthma patients with HOCS who did and did not initiate biologics. Methods: Baseline characteristics of patients with HOCS (long-term maintenance OCS therapy for at least 1 year, or ≥4 courses of stero

Evaluation of evidence supporting NICE recommendations to change people's lifestyle in clinical practice: cross sectional survey

Objectives To assess whether recommendations of individually oriented lifestyle interventions (IOLIs) in guidelines from the National Institute for Health and Care Excellence (NICE) were underpinned by evidence of benefit, and whether harms and opportunity costs were considered.Design Cross sectional survey.Setting UK.Data sources NICE guidelines and supporting evidence.Eligibility criteria All NI

Genotypic and phenotypic spectrum of infantile liver failure due to pathogenic TRMU variants

Purpose: The study aimed to define the genotypic and phenotypic spectrum of reversible acute liver failure (ALF) of infancy resulting from biallelic pathogenic TRMU variants and to determine the role of cysteine supplementation in its treatment. Methods: Individuals with biallelic (likely) pathogenic variants in TRMU were studied through an international retrospective collection of de-identified p

The European Union and the Value of Gender Equality

This chapter explores the value of gender equality in two areas of EU external relations: enlargement to include the accession countries of Central and Eastern Europe, and development policy with an emphasis on health, AIDS, and population policies. First, we will analyse the origins, history and institutionalisation of gender equality mechanisms in the European Union. Second, the impact of this v

Why residual emissions matter right now

Net-zero targets imply that continuing residual emissions will be balanced by carbon dioxide removal. However, residual emissions are typically not well defined, conceptually or quantitatively. We analysed governments’ long-term strategies submitted to the UNFCCC to explore projections of residual emissions, including amounts and sectors. We found substantial levels of residual emissions at net-ze

Pan-kinome of Legionella expanded by a bioinformatics survey

The pathogenic Legionella bacteria are notorious for delivering numerous effector proteins into the host cell with the aim of disturbing and hijacking cellular processes for their benefit. Despite intensive studies, many effectors remain uncharacterized. Motivated by the richness of Legionella effector repertoires and their oftentimes atypical biochemistry, also by several known atypical Legionell

A saturated map of common genetic variants associated with human height

Common single-nucleotide polymorphisms (SNPs) are predicted to collectively explain 40–50% of phenotypic variation in human height, but identifying the specific variants and associated regions requires huge sample sizes1. Here, using data from a genome-wide association study of 5.4 million individuals of diverse ancestries, we show that 12,111 independent SNPs that are significantly associated wit

Competitive devaluations in the 1930s: myth or reality?

Valutadeprecieringarna som följde på guldmyntfotens upplösning stimulerade den internationella ekonomin. Artikeln visar att länder som deprecierade endast tillfälligt eller inte alls fick fördelar på bekostnad av konkurrentländerna. Valutadeprecieringen ökade guldets värde och därmed de monetära reserverna, vilket gynnade återhämtningen från depressionen även för de länder som inte deprecierade. DThis article is the first examination of competitive devaluation in the 1930s using data on exchange rates. It analyses the impact of currency changes on foreign trade flows of fourteen industrialized countries 1929–1939. It reviews the development of nominal and real effective exchange rates together with trade and economic growth and conducts a disaggregated analysis of trade and bilateral excha

Farliga förbindelser : Kopplingen mellan Islamiska förbundet i Sverige och Muslimska brödraskapet

I den här artikeln ska jag framlägga argument för en kontroversiell tes. Nämligen att Islamiska förbundet i Sverige (IFiS), som äger och förvaltar Stora moskén på Södermalm i Stockholm, egentligen är en organisation som ingår i Muslimska brödraskapets (MB) nätverk av nationella organisationer och internationella samverkansorgan. MB är en legendarisk islamistisk organisation med rötter i Egypten, g

Mild-to-Moderate Kidney Dysfunction and Cardiovascular Disease: Observational and Mendelian Randomization Analyses

Background: End-stage renal disease is associated with a high risk of cardiovascular events. It is unknown, however, whether mild-to-moderate kidney dysfunction is causally related to coronary heart disease (CHD) and stroke. Methods: Observational analyses were conducted using individual-level data from 4 population data sources (Emerging Risk Factors Collaboration, EPIC-CVD [European Prospective

Double-hit separation and dE/dx resolution of a time projection chamber with GEM readout

A time projection chamber (TPC) with micropattern gaseous detector (MPGD) readout is investigated as main tracking device of the International Large Detector (ILD) concept at the planned International Linear Collider (ILC). A prototype TPC equipped with a triple gas electron multiplier (GEM) readout has been built and operated in an electron test beam. The TPC was placed in a 1 T solenoidal field

The 5-Hydroxymethylcytosine Landscape of Prostate Cancer

Analysis of DNA methylation is a valuable tool to understand disease progression and is increasingly being used to create diagnostic and prognostic clinical biomarkers. While conversion of cytosine to 5-methylcytosine (5mC) commonly results in transcriptional repression, further conversion to 5-hydroxymethylcytosine (5hmC) is associated with transcriptional activation. Here we perform the first st

Responsible gambling through a motivational telephone intervention to high-risk gamblers – An evaluation of user satisfaction and subjective intervention effects

Background and aims: Problem gambling causes major social and psychiatric consequences, and there is need to develop feasible harm-reducing or therapeutic interventions. It has been suggested that gambling operators with responsible gambling intentions can intervene in order to identify and help reduce the harm in problem gamblers. However, user satisfaction, and the risk of negative reactions and

Prevalence and global estimates of unsafe listening practices in adolescents and young adults : a systematic review and meta-analysis

Introduction This study aimed to determine the prevalence of unsafe listening practices from exposure to personal listening devices (PLDs) and loud entertainment venues in individuals aged 12-34 years, and to estimate the number of young people who could be at risk of hearing loss from unsafe listening worldwide. Methods We conducted a systematic review and meta-analysis to estimate the prevalence

Genome Evolution of a Symbiont Population for Pathogen Defense in Honeybees

The honeybee gut microbiome is thought to be important for bee health, but the role of the individual members is poorly understood. Here, we present closed genomes and associated mobilomes of 102 Apilactobacillus kunkeei isolates obtained from the honey crop (foregut) of honeybees sampled from beehives in Helsingborg in the south of Sweden and from the islands Gotland and Åland in the Baltic Sea.

Transient Flow and Heat Transfer in a Horizontal Rectangular Channel Considering Thermal-Fluid-Structure Interaction

For the supercritical n-decane horizontally flowing in a rectangular channel of an active regenerative cooling system, a transient thermal-fluid-structure coupling method is employed to investigate the unsteady thermal-hydraulic characteristics and the wall deformation at a starting stage. The temperature distributions of the fluid domain and solid domain along the flow direction are investigated