Malignant gliomas (MGs) are the most common malignant primary brain tumors with a short life estimate accompanied by a marked reduction in the quality of life. Herpes Simplex virus-1 thymidine kinase ganciclovir (HSV-TK/GCV) system is the best characterized enzyme prodrug therapy in use. However, lipophobicity of GCV and low enzymatic activity of HSV-TK reduce the treatment efficacy. Tomato TK (To

Completely analyzed and closed issue reports in software development projects, particularly in the development of safety-critical systems, often carry important information about issue-related change locations. These locations may be in the source code, as well as traces to test cases affected by the issue, and related design and requirements documents. In order to help developers analyze new issu

Numerous geometric problems in computer vision involve the solu- tion of systems of polynomial equations. This is particularly true for so called minimal problems, but also for finding stationary points for overdetermined prob- lems. The state-of-the-art is based on the use of numerical linear algebra on the large but sparse coefficient matrix that represents the original equations multi- plied wi

Experience-dependent alterations in the human brain's white-matter microstructure occur in early adulthood, but it is unknown whether such plasticity extends throughout life. We used cognitive training, diffusion-tensor imaging (DTI), and structural MRI to investigate plasticity of the white-matter tracts that connect the left and right hemisphere of the frontal lobes. Over a period of about 180 d

Inclusive e(+/-)p single and double differential cross sections for neutral and charged current deep inelastic scattering processes are measured with the H1 detector at HERA. The data were taken at a centre-of-mass energy of root s = 319 GeV with a total integrated luminosity of 333.7 pb(-1) shared between two lepton beam charges and two longitudinal lepton polarisation modes. The differential cro

Active micromixers with rotating elements are attractive microfluidic actuators in many applications because of their mixing ability at a short distance. However, miniaturising the impeller design poses technical challenges including the fabrication and driving means. As a possible solution inspired by macro magnetic bar-stirrers, this study proposes the use of tethered, rotating bacteria as mixin

For the very first time we present 3D simulations of planets embedded in stellar irradiated discs. It is well known that thermal effects could reverse the direction of planetary migration from inwards to outwards, potentially saving planets in the inner, optically thick parts of the protoplanetary disc. When considering stellar irradiation in addition to viscous friction as a source of heating, th

Drug abuse (DA) is a clinically heterogeneous syndrome. Can we, in a large epidemiological sample, identify clinical features of DA cases that index genetic risk?

Abstract in Norwegian Det er kjent fra før at langdistansebinding, altså binding over finitt setningsgrense, forekommer i norsk. Den geografiske distribusjonen av slike bindingsrelasjoner i norsk har blitt undersøkt tidligere, og det samme har visse semantiske og syntaktiske faktorer som gjør langdistansebinding mulig. I denne artikkelen presenteres resultater fra en ny undersøkelse av langdistans

Global health education is increasingly acknowledged as an opportunity for medical schools to prepare future practitioners for the broad health challenges of our time. The purpose of this study was to describe the evolution of global health education in Swedish medical schools and to assess students' perceived needs for such education.

A search for an excess of events with multiple high transverse momentum objects including charged leptons and jets is presented, using 20.3 fb(-1) of proton-proton collision data recorded by the ATLAS detector at the Large Hadron Collider in 2012 at a centre-of-mass energy of root s = 8 TeV. No excess of events beyond Standard Model expectations is observed. Using extra-dimensional models for blac

Determining the dynamic behaviour of lightweight buildings by means of finite element analyses requires models representing the geometry involved in great detail, resulting in systems having many millions of degrees of freedom. It is, therefore, important to avoid unnecessarily detailed models by carefully considering what is essential to include in the models and the level of details required for

Bai Nuur (41 degrees 38.590'N, 114 degrees 30.922'E, similar to 1346 m a.s.l.) and Ulan Nuur (41 degrees 44.214'N, 115 degrees 05.630'E, similar to 1246 m a.s.l.) are two small lakes situated in the transition zone between semi-humid and semi-arid climate regimes that runs parallel to the present limit of the southeast monsoon along the southeastern Inner Mongolia Plateau in north China. A 215 cm-

Typically, a significant fraction of phosphorus in soils is composed of organic phosphates, and this fraction thus plays an important role in the global phosphorus cycle. Here we have studied adsorption of monomethyl phosphate (MMP) to goethite (alpha-FeOOH) as a model system in order to better understand the mechanisms behind adsorption of organic phosphates to soil minerals, and how adsorption a

Global positioning system and time-depth recorders were deployed in combination to investigate the foraging behaviour of common murres Uria aalge breeding at Stora Karlsö Island, Baltic Sea, during the chick-rearing period. In the pre-breeding period the main prey species of murres, sprat Sprattus sprattus, is targeted by commercial fisheries, likely reducing prey availability during the breeding

The paper investigates further an approach to modeling dynamically changing Gaussian spatio-temporal fields. In that approach, the dynamics are introduced by embedding deterministic velocities into a stochastic spatio-temporal Gaussian model. In this way, a dynamically inactive stochastic field with given spatial and temporal covariance structure gains dynamics that in general follow a determinist

Members of the TALE (Three-amino acid loop extension) family of atypical homeodomain-containing transcription factors are important downstream effectors of oncogenic fusion proteins involving the mixed lineage leukemia (MLL) gene. A well-characterized member of this protein family is MEIS1, which orchestrates a transcriptional program required for the maintenance of MLL-rearranged acute myeloid le

Differences in survivorship of non-posterior-stabilized compared with posterior-stabilized knee designs carry substantial economic consequences, especially with limited health-care resources. However, these comparisons have often been made between relatively small groups of patients, often with short-term follow-up, with only small differences demonstrated between the groups. The goal of this stud