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The multivariate normal probability integral with a product correlation structure can be transformed to a one dimensional integral and easily evaluated when the correlation matrix is non-singular and well conditioned. However, the nearly singular case is much more difficult and previous methods fail to compute it with high numerical precision. This paper demonstrates that the (nearly) singular cas
Details of the mechanisms and selection pressures that shape the emergence and development of complex biological systems, such as the human immune system, are poorly understood. A recent definition of a reference set of proteins essential for the human immunome, combined with information about protein interaction networks for these proteins, facilitates evolutionary study of this biological machin
BACKGROUND: In clinical practice there is need for a simple and reliable test for determination of impaired renal function. With reductions in GFR, the plasma cystatin C concentration (C, mg/l) will increase earlier than serum creatinine, and it is generally agreed that plasma cystatin C is only little affected by body weight, age or sex. However, some reports indicate that cystatin C may be influ
Several people with Parkinson's disease have been treated with intrastriatal grafts of fetal dopaminergic neurons. Following autopsy, 10-22 years after surgery, some of the grafted neurons contained Lewy bodies similar to those observed in the host brain. Numerous studies have attempted to explain these findings in cell and animal models. In cell culture, α-synuclein has been found to transfer fro
This aim of this article is to critically examine how the concept of culture is used in Sweden to explain the “failure” or the difficulties that Muslim immigrant families are experiencing with regards to their integration into the dominant society. Whereas, the Swedish society is often represented as ‘modern’, ‘progressive’, and ‘democratic’, immigrants with Muslim backgrounds are predominately de
Recent decades have shown major improvements in survival rates after cardiac arrest. However, few interventions have been tested in order to improve the care for survivors and their family members. In many countries, including Sweden, national guidelines for post cardiac arrest care and follow-up programs are not available and current practice has not previously been investigated. The aim of this
Bolin K, Berggren F, Forsgren L. Lacosamide as treatment of epileptic seizures - cost utility results for Sweden. Acta Neurol Scand: DOI: 10.1111/j.1600-0404.2009.01320.x. (c) 2010 The Authors Journal compilation (c) 2010 Blackwell Munksgaard. Objectives - To calculate cost per additional quality-adjusted life-year (QALY) for lacosamide as adjunctive treatment for patients with uncontrolled partia
Calcitonin gene-related peptide (CGRP) is expressed throughout the CNS and peripheral nervous system, consistent with control of vasodilatation, nociception, motor function, secretion and olfaction. alphaCGRP is prominently localized in primary afferent C and Adelta fibres of spinal and trigeminal ganglia. Activation of the trigeminal nerve results in antidromic release of CGRP, acting through a C
Kostnaderna för att åtgärda fukt- och vattenskador i våra våtrum har ökat dramatiskt och oroväckande under senare år. I den skadeinventering som ingick i SABOs stora projekt 'Fukt och mögel i flerbostadshus' uppvisade 11,3 procent av våtrummen skador av olika slag
