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Succession of bacterial biofilm communities following removal of chloramine from a full-scale drinking water distribution system

Monochloramine is used to regulate microbial regrowth in drinking water distribution systems (DWDS) but produces carcinogenic disinfection byproducts and constitutes a source of energy for nitrifying bacteria. This study followed biofilm-dispersed microbial communities of a full-scale DWDS distributing ultrafiltered water over three years, before and after removal of monochloramine. Communities we

Effect of Disulfiram and Copper Plus Chemotherapy vs Chemotherapy Alone on Survival in Patients with Recurrent Glioblastoma : A Randomized Clinical Trial

Importance: Disulfiram has demonstrated broad antitumoral effect in several preclinical studies. One of the proposed indications is for the treatment of glioblastoma. Objective: To evaluate the efficacy and safety of disulfiram and copper as add-on to alkylating chemotherapy in patients with recurrent glioblastoma. Design, Setting, and Participants: This was a multicenter, open-label, randomized p

Effect of dronedarone vs. placebo on atrial fibrillation progression : a post hoc analysis from ATHENA trial

AIMS: This post hoc analysis of the ATHENA trial (NCT00174785) assessed the effect of dronedarone on the estimated burden of atrial fibrillation (AF)/atrial flutter (AFL) progression to presumed permanent AF/AFL, and regression to sinus rhythm (SR), compared with placebo. METHODS AND RESULTS: The burden of AF/AFL was estimated by a modified Rosendaal method using available electrocardiograms (ECG)

Gambling and COVID-19 : Swedish national gambling data from a state-owned gambling sports and casino operator

Background and aims: The lockdown of sports and gambling venues during the coronavirus disease 2019 (COVID-19) pandemic caused a fear of increased gambling on other online gambling types, with a risk for transfer to more addictive gambling than otherwise. This study aimed to estimate changes in gambling activity during COVID-19-affected periods among all gamblers at a Swedish state-owned gambling

Shared mental representations underlie metaphorical sound concepts

Communication between sound and music experts is based on the shared understanding of a metaphorical vocabulary derived from other sensory modalities. Yet, the impact of sound expertise on the mental representation of these sound concepts remains blurry. To address this issue, we investigated the acoustic portraits of four metaphorical sound concepts (brightness, warmth, roundness, and roughness)

Process development for an effective COVID-19 vaccine candidate harboring recombinant SARS-CoV-2 delta plus receptor binding domain produced by Pichia pastoris

Recombinant protein-based SARS-CoV-2 vaccines are needed to fill the vaccine equity gap. Because protein-subunit based vaccines are easier and cheaper to produce and do not require special storage/transportation conditions, they are suitable for low-/middle-income countries. Here, we report our vaccine development studies with the receptor binding domain of the SARS-CoV-2 Delta Plus strain (RBD-DP

Activation and Participation in Ecological Sound Art

Showing of two installations that result from an ecological sound art practice and its complex and radical modulation of performing/composing/curating within assemblages. The works spring out of an ecological-enactive approach, where through relational technique and fleshy listening the authors explore what the performative body can do; what connections and networks it creates across temporality a

MAKING A MARKET : INFRASTRUCTURE, INTEGRATION, AND THE RISE OF INNOVATION

—We exploit exogenous variation arising from the historical roll-out of the Swedish railroad network across municipalities to identify the impacts of improved transport infrastructure on innovative activity. A network connection led to a local surge in patenting due to an increased entry and productivity of inventors. As the railroad network expanded, inventors in connected areas began to develop

Detailed α abundance trends in the inner Galactic bulge

Context. Until now, heavy interstellar extinction has meant that only a few studies of chemical abundances have been possible in the inner Galactic bulge. However, it is crucial to learn more about this structure in order to better understand the formation and evolution of the centre of the Galaxy and galaxies in general. Aims. In this paper, we aim to derive high-precision α-element abundances us

Global Water Quality of Inland Waters with Harmonized Landsat-8 and Sentinel-2 Using Cloud-Computed Machine Learning

Modeling inland water quality by remote sensing has already demonstrated its capacity to make accurate predictions. However, limitations still exist for applicability in diverse regions, as well as to retrieve non-optically active parameters (nOAC). Models are usually trained only with water samples from individual or local groups of waterbodies, which limits their capacity and accuracy in predict

Laparoscopic lavage for Hinchey III perforated diverticulitis : factors for treatment failure in two randomized clinical trials

BACKGROUND: The Scandinavian Diverticulitis (SCANDIV) trial and the LOLA arm of the LADIES trial randomized patients with Hinchey III perforated diverticulitis to laparoscopic peritoneal lavage or sigmoid resection. The aim of this analysis was to identify risk factors for treatment failure in patients with Hinchey III perforated diverticulitis.METHODS: This was a post hoc analysis of the SCANDIV

Pre-activation negativity in language brain potentials

The pre-activation negativity (PrAN) is an event-related potential (ERP) component indexing how constraining phonological cues are. It has an early phase (136-200 ms), with sources in the left auditory cortices, and a late phase (200 ms onwards), with sources in Broca’s area. The PrAN has been found for segmental and prosodic cues increasing the certainty about upcoming words, morphemes, grammatic

Wealth and Child Mortality in the Nineteenth-Century United States: Evidence from Three Panels of American Couples, 1850-1880

With only a few exceptions, the historical study of individual-level correlates of child mortality in the United States has been limited to the period surrounding the turn of the twentieth century, when children ever born and children surviving data collected by the 1900 and 1910 censuses allow indirect estimation of child mortality. The recent release of linked census data, such as the IPUMS MLP

Introduction to Fatal Years 30 Years Later: New Research on Child Mortality in the Past Special Issue

2021 marked the 30-year anniversary of the publication Fatal Years: Child Mortality in the late Nineteenth-Century United States, a pioneering work in historical demography by Samuel H. Preston and Michael R. Haines. This special issue showcases the current state of historical mortality studies through a collection of articles originally presented at two commemorative sessions at the 2021 meeting