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Phase behavior of semifluorinated catanionic mixtures: Head group dependence and spontaneous formation of vesicles

Hexadecyltrimethylammonium bromide (C(16)TAB)-sodium perfluorooctanoate (C8FONa) and hexadecylpyridynium bromide (C16PyB)-(C8ONa catanionic semifluorinated mixtures have been studied by conductivity, dynamic light scattering (DLS), cryo-transmission electron microscopy (cryo-TEM) and polarizing microscopy. The regular Solution theory, applicable for a limited fluorinated molar ratio, does not pred

Towards comprehensive experience-based decision support

In today’s software development organizations, methods and tools are employed that frequently lack sufficient evidence regarding their suitability, limits, qualities, costs, and associated risks. The need to select the best-suited method, technique or tool in a given business context is becoming more and more important. From a business perspective the trade-off between time-to-market, quality, and

Ultrasound characteristics of different types of adnexal malignancies.

Objective. To describe ultrasound characteristics of adnexal malignancies, i.e., borderline ovarian tumors, primary invasive ovarian epithelial cancer stage 1, primary invasive ovarian epithelial cancer stages 2–4, rare types of malignancy, and metastatic tumors. Methods. In a prospective international study involving nine European ultrasound centers, 1066 women with a pelvic mass judged to be

Nanosecond to Microsecond Protein Dynamics Probed by Magnetic Relaxation Dispersion of Buried Water Molecules

Large-scale protein conformational motions on nanosecond – microsecond time scales are important for many biological processes, but remain largely unexplored because of methodological limitations. NMR relaxation methods can access these time scales if protein tumbling is prevented, but the isotropy required for high-resolution solution NMR is then lost. However, if the immobilized protein molecule

Evaluation and visualisation of surface defects on auto-body panels

The ability to predict surface defects in outer panels is of vital importance in the automotive industry, especially for brands in the premium car segment. Today, measures to prevent these defects cannot be taken until a test part has been manufactured, which requires a great deal of time and expense. The decision as to whether a certain surface is of acceptable quality or not is based on subjecti

Precipitation as driver of carbon fluxes in 11 African ecosystems

This study reports carbon and water fluxes between the land surface and atmosphere in eleven different ecosystems types in Sub-Saharan Africa, as measured using eddy covariance (EC) technology in the first two years of the CarboAfrica network operation. The ecosystems for which data were available ranged in mean annual rainfall from 320 mm (Sudan) to 1150 mm (Republic of Congo) and include a spect

ADAM12 is a four-leafed clover - The excised prodomain remains bound to the mature enzyme

The ADAMs (a disintegrin and metalloprotease) comprise a family of multidomain proteins with metalloprotease, cell adhesion, and signaling activities. Human ADAM12, which is implicated in diseases such as cancer, is expressed in two splice forms, the transmembrane ADAM12-L and the shorter and soluble ADAM12-S. ADAM12 is synthesized as a zymogen with the prodomain keeping the metalloprotease inacti

A phase 3 randomized controlled trial of the efficacy and safety of atrasentan in men with metastatic hormone-refractory prostate cancer

BACKGROUND. The objective of this study was to evaluate the efficacy and safety of atrasentan (Xinlay), a selective endothelin-A receptor antagonist, in patients with metastatic hormone- refractory prostate cancer (HRPC). METHODS. This multinational, double-blind, placebo-controlled trial enrolled 809 men with metastatic HRPC. Patients were randomized 1:1 to receive either atrasentan 10 mg per day

A Cordylodus fauna from the SW Gulf of Bothnia, Sweden

A conodont fauna including several species of Cordylodus was retrieved from two glacial siltstone boulders found on the shore of Lilltuppen, a small island immediately off the Swedish coast in the Gulf of Bothnia at c. 61 degrees N, 17 degrees E. The erratics are remnants of a poorly known level in the Swedish stratigraphic succession. They probably derive from a nearby point on the floor of the B

Identification of numerical and structural chromosome aberrations in 15 high hyperdiploid childhood acute lymphoblastic leukemias using spectral karyotyping

Spectral karyotyping (SKY) on metaphase spreads from 15 high hyperdiploid (>51 chromosomes) childhood acute lymphoblastic leukemias (ALL), which typically display a poor chromosome morphology, was performed in order to investigate the pattern of numerical abnormalities, reveal the chromosomal origin of marker chromosomes, and identify translocations and other interchromosomal rearrangements not de

Contribution of suspended and sorbed groundwater bacteria to degradation of dissolved and sorbed aniline

The influence of sorption on the mineralisation of 50 mug aniline l(-1) was examined in an aquifer material under batch conditions. The study was designed to distinguish the rates and extent of biodegradation of the sorbed and the dissolved trace organic and the contribution of sorbed and suspended bacteria to the degradation. Four different mathematical models were developed with different assump

On the effect of lactic acid on blood glucose and insulin responses to cereal products: Mechanistic studies in healthy subjects and in vitro

It has been observed that bread containing lactic acid produced during the sourdough fermentation or added directly, has the ability to lower the postprandial glucose and insulin responses in humans. The main objective of the present work was to evaluate the possible mechanisms for a lowered glucose response to bread containing lactic acid, and to determine whether the same phenomenon also occurs

Using the cue elimination technique to derive an equation between performance in episodic tests

Lawful equations describing relations between empirical measurable variables, that are free of fitted parameters, and that can be derived from simple assumptions, are rare in psychology. However, this paper proposes one such equation that describes the relation between the performances on four different explicit episodic memory tests: free recall, cued recall, recognition, and cued recognition. Th

Working memory training decreases hippocampal neurogenesis.

The relationship between adult hippocampal neurogenesis and cognition appears more complex than suggested by early reports. We aimed to determine if the duration and task demands of spatial memory training differentially affect hippocampal neurogenesis. Adult male rats were trained in the Morris water maze in a reference memory task for 4 days, or alternatively working memory for either 4 or 14 da