Coronavirus disease 2019 (COVID-19) has led to a worldwide pandemic that continues to transform but will not go away. Cardiovascular dysautonomia in postacute sequelae of severe acute respiratory syndrome coronavirus 2 infection has led to persistent symptoms in a large number of patients. Here, we define the condition and its associated symptoms as well as potential mechanisms responsible. We pro

BACKGROUND: Deregulated lipid metabolism is common in cancer cells and the mevalonate pathway, which synthesizes cholesterol, is central in lipid metabolism. This study aimed to assess statin-induced changes of the intratumoral levels of cholesterol and the expression of the low-density lipoprotein receptor (LDLR) to enhance our understanding of the role of the mevalonate pathway in cancer cholest

Background and Purpose: In recent years, the treatment landscape for breast cancer has undergone significant advancements, with the introduction of several new anticancer agents. One such agent is trastuzumab emtansine (T-DM1), an antibody drug conjugate that has shown improved outcomes in both early and advanced breast cancer. However, there is currently a lack of comprehensive evidence regarding

Probabilistic numerical solvers for ordinary differential equations compute posterior distributions over the solution of an initial value problem via Bayesian inference. In this paper, we leverage their probabilistic formulation to seamlessly include additional information as general likelihood terms. We show that second-order differential equations should be directly provided to the solver, inste

In this letter, we propose a class of efficient, accurate, and general methods for solving state-estimation problems with equality and inequality constraints. The methods are based on recent developments in variable splitting and partially observed Markov processes. We first present the generalized framework based on variable splitting, then develop efficient methods to solve the state-estimation

In this letter, we analyze certain student's t-filters for linear Gaussian systems with misspecified noise covariances. It is shown that under appropriate conditions, the filter both estimates the state and re-scales the noise covariance matrices in a Kullback-Leibler optimal fashion. If the noise covariances are misscaled by a common scalar, then the re-scaling is asymptotically exact. We also co

Torskpopulationen i Östersjön påverkas negativt av övergödning och överfiske. Man vill därav främja torskpopulationen omkring Hanö genom att placera ut artificiella rev. Sedimentprov har samlats in från fyra lokaler där kornstorleksanalys genomfördes på sedimenten för att undersöka möjligheten att placera artificiella rev i området. Två av lokalerna har bra geologiska förutsättningar, hårdbotten mThe cod population in the Baltic Sea is negatively affected by eutrophication and overfishing. The aim is to promote the cod population around Hanö by placing artificial reefs. Sediment samples have been collected from four sites where grain size analysis was performed on the sediments to investigate the possibility of placing artificial reefs in the area. Two of the sites have suitable geological

In affluent nations, variations in obstetric care, particularly during emergencies, perplexingly manifest in differing intervention and outcome rates. Although these variations mirror systemic disparities, they are also suggested to reflect the interplay of social and professional interactions between obstetricians/gynecologists and midwives, stemming from adherence to distinct professional paradi

When other people look directly towards us, we often respond by looking back at them, and such direct-gaze responses are important for establishing eye contact. Atypical eye contact is common in autism, but how and when this aspect of autism develops is not well understood. Here, we studied whether how much and how quickly infants respond to others' direct gaze is associated with autism in toddler

Single-cell phenotyping based on biophysical properties is a promising tool to distinguish cell types and their response to a given condition, and charting such properties also enables optimization of cell separations. Isoacoustic focusing, where cells migrate to their points of zero acoustic contrast in an acoustic impedance gradient, added the effective acoustic impedance of cells to the directo

The industrialization of agriculture and efforts to maximize yields of commodity crops are major drivers of biodiversity loss and disruption of ecosystems balance. To become more sustainable, agriculture needs to be aligned with the delivery of multiple ecosystem services, and reduce its dependency on external inputs and its negative environmental impacts. Increasing crop diversity may be a key st

This chapter discusses Ilia Repin’s court commission, Reception of Volost Elders by Alexander III in the Courtyard of the Petrovsky Palace in Moscow (1886). It argues that the painting reflected marginalizing discourses on the non-Russian minorities dominant at the outset of Alexander III’s rule. Repin employed a differentiating approach to rendering ethnically and religiously diverse representati