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A novel broad-spectrum elastase-like serine protease from the predatory bacterium bdellovibrio bacteriovorus facilitates elucidation of site-specific IgA glycosylation pattern

The increased interest in predatory bacteria due to their ability to kill antibiotic resistant bacteria has also highlighted their inherent plethora of hydrolytic enzymes, and their potential as natural sources of novel therapeutic agents and biotechnological tools. Here, we have identified and characterized a novel protease from the predatory bacterium Bdellovibrio bacteriovorus: BspE (Bdellovibr

Multiple dimensions for random walks

Current trends in diffusion NMR and MRI methods development are reviewed. While great efforts are still directed towards further improving the spectral, spatial, and relaxation rate resolution of basic diffusion measurements, recent improvements in magnetic field gradient technology on whole-body scanners have enabled an exciting line of research involving MRI implementations of advanced diffusion

Thermal performance enhancement in a wedge duct with in-line pin fins combined with vortex generators

Purpose: The purpose of this paper is to enhance the heat transfer and thermal performance in the trailing edge region of the vane with vortex generators (VGs). Design/methodology/approach: This numerical study presents the enhancement of thermal performance in the trailing part of a gas turbine blade. In the trailing part, generally, pin fins are used either in staggered or in-line arrangements t

Biomodulation of an implant for enhanced bone-implant anchorage

Aseptic loosening of implants is the major cause for revision surgery. By modulating the bone-implant interface, early bone-implant anchorage could be improved. Implant surface manipulation by the addition of osteopromotive molecules locally and systemically to promote implant integration has been described with limited success. This study describes a novel approach by making the implant capable o

Band-selective dynamics in charge-transfer excited iron carbene complexes

Ultrafast dynamics of photoinduced charge transfer processes in light-harvesting systems based on Earth-abundant transition metal complexes are of current interest for the development of molecular devices for solar energy conversion applications. A combination of ultrafast spectroscopy and first principles quantum chemical calculations of a recently synthesized iron carbene complex is used to eluc

Work identity development in young adults with mental health problems

Background: How we identify ourselves is strongly related to employment. Young adults are a vulnerable group with regard to entering the Labor market. If they also have mental health problems, entering becomes more difficult and increases risk of early marginalization. Nevertheless, working can be essential for personal recovery process. Aims: To explore experiences of young adults with mental hea

Exit as governance : do blockholders affect corporate innovation in large US firms?

Using a sample of large US firms, this study shows that blockholders in combination with liquidity can contribute positively to innovation (R&D investments). We contribute to the literature on managerial myopia that has focused mainly on large owners and their type (short-term/long-term). Our results are in line with recent theoretical studies arguing that blockholders in combination with mark

Framing brain drain : between solidarity and skills in European labor mobility

How do crisis perceptions interrelate with the emergence and re-constitution of policy problems? By using a novel combination of interviews with a content and network analysis of hand-coded parliamentary questions, this article maps the emergence of brain drain as a policy problem at the level of the European Union and follows the evolution of the issue over the last four parliamentary periods (fr

The Creation of Transnational Memory Spaces : Professionalization and Commercialization

In the age of globalization, local memories of past violence are often dislocated from their material places as remembrance is transpiring in transnational memory spaces. Historical events and commemorative memory practices increasingly transcend national boundaries and change the way memories of historical violence, atrocity, and genocide are represented in the transnational memoryscape. This art

Revisiting Public Support for the Euro, 1999–2017 : Accounting for the Crisis and the Recovery

This article explores the evolution and determinants of public support for the euro since its creation in 1999 until the end of 2017, thereby covering the pre-crisis experience of the euro, the crisis years and the recent recovery. Using uniquely large macro and micro databases and applying up-to-date econometric techniques, the authors revisit the growing literature on public support for the euro

Global diversity and biogeography of bacterial communities in wastewater treatment plants

Microorganisms in wastewater treatment plants (WWTPs) are essential for water purification to protect public and environmental health. However, the diversity of microorganisms and the factors that control it are poorly understood. Using a systematic global-sampling effort, we analysed the 16S ribosomal RNA gene sequences from ~1,200 activated sludge samples taken from 269 WWTPs in 23 countries on

Defence versus defence : Are crucian carp trading off immune function against predator-induced morphology?

Numerous species adopt inducible defence strategies; that is, they have phenotypically plastic traits that decrease the risk of capture and consumption by potential predators. The benefits of expressing alternative phenotypes in high- vs. low-risk environments are well documented. However, inducible anti-predator traits are also expected to incur costs, as they are not expressed when predators are

Coherent soft X-ray pulses from an echo-enabled harmonic generation free-electron laser

X-ray free-electron lasers (FELs), which amplify light emitted by a relativistic electron beam, are extending nonlinear optical techniques to shorter wavelengths, adding element specificity by exciting and probing electronic transitions from core levels. These techniques would benefit tremendously from having a stable FEL source, generating spectrally pure and wavelength-tunable pulses. We show th

Active Posts in Deterministic Lateral Displacement Devices

Using electrically connected metal-coated posts in a deterministic lateral displacement (DLD) device and applying electric fields, electrokinetics is used to tune separations, significantly decrease the critical size for separation, and increase the dynamic range with switching times on the order of seconds. The strength of DLD stems from its binary behavior. To first approximation, particles move

Decision-making process for addressing bottleneck problems in district heating networks

Lower system temperatures in district heating (DH) grids are important factors for system efficiency. Lower system temperatures lead, for example, to lower heat losses and higher production unit efficiency. One obstacle to lower supply temperatures are so-called bottlenecks in DH networks. Bottlenecks are areas in DH networks of very low differential pressure, which makes it difficult to supply th