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Holotranscobalamin is not influenced by decreased renal function in elderly men: the MrOS Sweden study

Background Subclinical cobalamin deficiency is common in the elderly, but the sensitivity and specificity of serum total cobalamin for this diagnosis is poor. Serum holotranscobalamin (holoTC), a measure of biologically available cobalamin, is considered a better marker for early cobalamin depletion than total cobalamin. However, in elderly populations, health-related reference intervals for holoT

The Value of Intimacy - Negotiating Commercial Friendship in Lifestyle Entrepreneurship

With the aim to reconsider lifestyle values in relation to economic rationality in small tourism and hospitality businesses, we focus on the “commercial home” as a site where boundaries between personal and commercial values are constantly performed in practice. Through an interactionist analysis of the narrative of a B&B and gallery owner, we illustrate the emergence of intimacy as a commerci

Ultrafast Dynamics of Long Homologues of Carotenoid Zeaxanthin

Three zeaxanthin homologues with conjugation lengths N of 15, 19, and 23 denoted as Z15, Z19, and Z23 were studied by femtosecond transient absorption spectroscopy, and the results were compared to those obtained for zeaxanthin (Z11). The energies of S2 decrease from 20 450 cm(-1) (Z11) to 18 280 cm(-1) (Z15), 17?095 cm(-1) (Z19), and 16?560 cm(-1) (Z23). Fitting the N dependence of the S-2 energi

Identification of three novel FGF16 mutations in X-linked recessive fusion of the fourth and fifth metacarpals and possible correlation with heart disease.

Nonsense mutations in FGF16 have recently been linked to X-linked recessive hand malformations with fusion between the fourth and the fifth metacarpals and hypoplasia of the fifth digit (MF4; MIM#309630). The purpose of this study was to perform careful clinical phenotyping and to define molecular mechanisms behind X-linked recessive MF4 in three unrelated families. We performed whole-exome sequen

On Modeling and Nonlinear Model Reduction in Automotive Systems

The current control design development process in automotive industry and elsewhere involves many expensive experiments and hand-tuning of control parameters. Model based control design is a promising approach to reduce costs and development time. In this process low complexity models are essential and model reduction methods are very useful tools. This thesis combines the areas of modeling and mo

Health Is Health Is Health? Age Differences in Intraindividual Variability and in Within-Person Versus Between-Person Factor Structures of Self-Reported Health Complaints

The variability of health complaints within individuals across time has rarely been studied, and the question whether between- and within-person factor structures of health-related variables are equivalent has not been tested so far. We examined self-reported health complaints in 101 younger (20-31 years) and 103 older adults (65-80 years) over a period of 100 daily assessments. Data were analyzed

Strong Schottky barrier reduction at Au-catalyst/GaAs-nanowire interfaces by electric dipole formation and Fermi-level unpinning

Nanoscale contacts between metals and semiconductors are critical for further downscaling of electronic and optoelectronic devices. However, realizing nanocontacts poses significant challenges since conventional approaches to achieve ohmic contacts through Schottky barrier suppression are often inadequate. Here we report the realization and characterization of low n-type Schottky barriers (~0.35 e

Scalable Positivity Preserving Model Reduction Using Linear Energy Functions

In this paper, we explore positivity preserving model reduction. The reduction is performed by truncating the states of the original system without balancing in the classical sense. This may result in conservatism, however, this way the physical meaning of the individual states is preserved. The reduced order models can be obtained using simple matrix operations or using distributed optimization m

Detection of body position changes from the ECG using a Laplacian noise model

Body position changes (BPCs) are manifested as shifts in the electrical axis of the heart, which may lead to ST changes in the ECG, misclassified as ischemic events. This paper presents a novel BPC detector based on a Laplacian noise model. It is assumed that a BPC can be modelled as a step-like change in the two coefficient series that result from the Karhunen-Loeve transform of the QRS complex a

Metabolic effects of milk protein intake strongly depend on pre-existing metabolic and exercise status

Milk protein intake has recently been suggested to improve metabolic health. This Perspective provides evidence that metabolic effects of milk protein intake have to be regarded in the context of the individual's pre-existing metabolic and exercise status. Milk proteins provide abundant branched-chain amino acids (BCAAs) and glutamine. Plasma BCAAs and glutamine are increased in obesity and insuli

Protein Flexibility and Conformational Entropy in Ligand Design Targeting the Carbohydrate Recognition Domain of Galectin-3.

Rational drug design is predicated on knowledge of the three-dimensional structure of the protein-ligand complex and the thermodynamics of ligand binding. Despite the fundamental importance of both enthalpy and entropy in driving ligand binding, the role of conformational entropy is rarely addressed in drug design. In this work, we have probed the conformational entropy and its relative contributi

In-tunnel vehicular radio channel characterization

Abstract in UndeterminedInside a tunnel, electromagnetic wave propagation differs strongly from the well understood "open-air" situation. The characterization of the tunnel environment is crucial for deploying vehicular communication systems. In this paper we evaluate vehicle-to-vehicle (V2V) radio channel measurements inside a tunnel. We estimate the time-varying root mean square (rms) delay and

A topical microemulsion for the prevention of allergic rhinitis symptoms: results of a randomized, controlled, double-blind, parallel group, multicentre, multinational clinical trial (Nares study)

Background: Since barrier protection measures to avoid contact with allergens are being increasingly developed, we assessed the clinical efficacy and tolerability of a topical nasal microemulsion made of glycerol esters in patients with allergic rhinitis. Methods: Randomized, controlled, double-blind, parallel group, multicentre, multinational clinical trial in which adult patients with allergic r

Flow-pattern based heat transfer correlations for stable flow boiling in micro/minichannels

Flow-pattern based heat transfer correlations for elongated bubbly flow and annular flow in stable flow boiling micro/minichannels were developed separately based on a collected micro/minichannel heat-transfer database by using an improved conventional-to-micro/minichannel threshold Bo = 4 and BoRel0.5 = 200, where Bo is the Bond number and Rel is the liquid Reynolds number. As significant disagre