The landscape of submicroscopic structural variants at the OPN1LW/OPN1MW gene cluster on Xq28 underlying blue cone monochromacy

Blue cone monochromacy (BCM) is an X-linked retinal disorder characterized by low vision, photoaversion, and poor color discrimination. BCM is due to the lack of long-wavelength-sensitive and middle-wavelength-sensitive cone photoreceptor function and caused by mutations in the OPN1LW/OPN1MW gene cluster on Xq28. Here, we investigated the prevalence and the landscape of submicroscopic structural v

Svante Thuresson & Claes Crona Trio, ”Svante möter Beppe Wolgers”, Riksteatern-turné 22 oktober-1 november

Stacey Kent med Jim Tomlinson & Claes Crona Trio, turné 2-6 november

Peter Asplund ”Aspiration” med Vivian Buczek och Martin Sjöstedt ”Songwriters’ Guide”, Konserthuset, Stockholm

Svante Thuresson & Claes Crona Trio, ”Svante möter Beppe Wolgers”, Riksteatern-turné 8-16 november

Peter Asplund ”All My Septembers”

πBO: Augmenting Acquisition Functions with User Beliefs for Bayesian Optimization

Bayesian optimization (BO) has become an established framework and popular tool for hyperparameter optimization (HPO) of machine learning (ML) algorithms. While known for its sample-efficiency, vanilla BO can not utilize readily available prior beliefs the practitioner has on the potential location of the optimum. Thus, BO disregards a valuable source of information, reducing its appeal to ML prac

NMR studies on lipid-peptide co-aggregation between ganglioside-containing membranes and α-synuclein

This topic of this thesis is how the presence of biomembrane molecules affect the behavior of a protein related to Parkinson’s disease in a simplified (compared to in the cell) model system.Lipids are fat molecules that make up the biological barriers in our body that control transport of essential molecules in and out of the cell and create an environment where membrane proteins can perform their

Svante Thuresson & Claes Crona Trio, ”Svante möter Beppe Wolgers”, Riksteatern-turné 20-24 november

Svante Thuresson & Claes Crona Trio, turné 28-30 november

Peter Asplund ”The Christmas Feeling”, turné 12-15 december

Peter Asplund ”Aspiration” feat. Robert Nordmark, ”Filharmonins dag”, Konserthuset, Stockholm

Peter Asplund, Isabella Lundgren, Sharon Dyall, Nils Landgren & Blue House Jazz Orchestra, Konserthuset, Stockholm

Veronica Swift, Jim Snidero & Claes Crona Trio, turné 27-28 februari

Anders Chico Lindvall, Glenn Miller Café, Stockholm

Computational Single-Cell Genomics Methods for Cell State Estimation and their Application to Hematopoietic Systems

The focus of this doctoral dissertation was to develop novel and scalable computational genomics methods for analysing single-cell genomic modalities. Scarf, a highly memory-efficient single-cell data analysis toolkit, was developed to enable an analysis of very large-scale datasets on personal computers, and the execution of parallel workflows on server-scale computational systems. The advances i

Peter Asplund ”Aspiration” feat. Lars Jansson, Fasching, Stockholm

Metabolically Defined Body Size Phenotypes and Risk of Endometrial Cancer in the European Prospective Investigation into Cancer and Nutrition (EPIC)

Background: Obesity is a risk factor for endometrial cancer but whether metabolic dysfunction is associated with endometrial cancer independent of body size is not known. Methods: The association of metabolically defined body size phenotypes with endometrial cancer risk was investigated in a nested case–control study (817 cases/ 817 controls) within the European Prospective Investigation into Canc

Sven Berggren ”Steve Swallow”, Glenn Miller Café, Stockholm

Peter Asplund ”Aspiration” feat. Lars Jansson, turné 22-24 september