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Regulation of normal and cancer cells as a base for cell cycle-targeted therapy

Popular Abstract in Swedish De flesta cancerpatienter dör på grund av spridning av tumörceller till olika organ. Invasiv och metastaserande cancer svarar ofta inte på behandling och blir då i många fall dödlig. Leukemi är en elakartad sjukdom av blodceller, som påverkar blod-producerande organ. Den höga förekomsten av leukemi förekommer i äldre befolkningen och hos barn. Leukemi återfall och resiThe majority of current treatments used for treatment of prostate cancer (PCa) and leukemia are often limited to a narrow subsets of treated patients. As such, there still remains a significant scope for gaining deeper understanding of molecular mechanisms underlying cancer metastasis for improvement of targeted treatment. Elevated expression of a cell cycle regulator cyclin A1 initiated leukemia

Absence and presence of social complexity in the marketization of sustainable tourism

The EU strategy for rural development 2014-2020 proposes a focus on tourism as a solution to bring economic, environmental and social aspects of sustainable development together. Using the case of fishing tourism in Sweden, we discuss the marketization of sustainable development on a destination market. We focus on the discursive and practical tension between ambitions for development and maintena

Vibration reduction by landscape shaping at high-tech facility.

Abstract in UndeterminedThis paper presents a numerical study on the reduction of vibrations in the ground. The influence of landscape shaping to reduce vibration levels induced by traffic is investi-gated by means of the finite element method with dynamic analyses. Both two-dimensional as well as three-dimensional finite element models are employed for the investigations. A har-monic point force

Bacterial control of host gene expression through RNA polymerase II

The normal flora furnishes the host with ecological barriers that prevent pathogen attack while maintaining tissue homeostasis. Urinary tract infections (UTIs) constitute a highly relevant model of microbial adaptation in which some patients infected with Escherichia coil develop acute pyelonephritis, while other patients with bacteriuria exhibit an asymptomatic carrier state similar to bacterial

First flush effect from vegetated roofs during simulated rain events

Abstract in UndeterminedVegetated roofs are becoming increasingly popular in urban environments. Still, several aspects of their influence on various urban infrastructures are not sufficiently investigated, including the roofs' influence on runoff water quality. In this study a first flush effect in runoff water from vegetated roofs during simulated artificial rain events is investigated. Example

Polarization corrections to single-particle energies studied within the energy-density-functional and quasiparticle random-phase approximation approaches

Background: Models based on using perturbative polarization corrections and mean-field blocking approximation give conflicting results for masses of odd nuclei. Purpose: We systematically investigate the polarization and mean-field models, implemented within self-consistent approaches that use identical interactions and model spaces, to find reasons for the conflicts between them. Methods: For den

Climate Change : Believing and seeing implies adapting

Knowledge of factors that trigger human response to climate change is crucial for effective climate change policy communication. Climate change has been claimed to have low salience as a risk issue because it cannot be directly experienced. Still, personal factors such as strength of belief in local effects of climate change have been shown to correlate strongly with responses to climate change an

Dynamics of strongly correlated fermions: Ab initio results for two and three dimensions

Quantum transport of strongly correlated fermions is of central interest in condensed matter physics. While the stationary expansion dynamics have recently been measured with cold atoms in 2D optical lattices, ab initio simulations have been limited to 1D setups so far. Here, we present the first precise fermionic quantum dynamics simulations for 2D and 3D. The simulations are based on nonequilibr

Antagonistic and synergistic effects of fungal and bacterial growth in soil after adding different carbon and nitrogen sources

The effect of adding easily available and more complex carbon sources, with and without nitrogen, on fungal and bacterial growth and activity in soil were studied in the laboratory. Total microbial activity was estimated by measuring respiration, fungal growth with the acetate-in-ergosterol incorporation technique and bacterial growth with the thymidine and leucine incorporation techniques. The su

Unraveling of free-carrier absorption for terahertz radiation in heterostructures

The relation between free-carrier absorption and intersubband transitions in semiconductor heterostructures is resolved by comparing a sequence of structures. Our numerical and analytical results show how free-carrier absorption evolves from the intersubband transitions in the limit of infinite number of wells with vanishing barrier width. It is explicitly shown that the integral of the absorption

Stemmer

Artikeln utgör en läsning och kritik av de 12 böcker som utgavs av Aschehougs förlag i samband med 100 års-jubileet av kvinnlig rösträtt i Norge. Författarna inkluderar Toril Moi, Marthe Ramm Frotun, Mariken Halle, Agnes Ravatn m fl.

Downsides of Robot-assisted Laparoscopic Radical Prostatectomy: Limitations and Complications

Context: Robot-assisted laparoscopic radical prostatectomy (RALP) using the da Vinci Surgical System (Intuitive Surgical, Sunnyvale, CA, USA) is now in widespread use for the management of localised prostate cancer (PCa). Many reports of the safety and efficacy of this procedure have been published. However, there are few specific reports of the limitations and complications of RALP. Objective: Th