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Distinct Serotypes of Streptococcal M Proteins Mediate Fibrinogen-Dependent Platelet Activation and Proinflammatory Effects

Sepsis is a life-threatening complication of infection that is characterised by a dysregulated inflammatory state and disturbed hemostasis. Platelets are the main regulators of hemostasis, and they also respond to inflammation. The human pathogen Streptococcus pyogenes can cause local infection that may progress to sepsis. There are more than 200 different serotypes of S. pyogenes defined accordin

Potential antidiabetic phytochemicals in plant roots : a review of in vivo studies

Background: Medicinal plants are used to treat various disorders, including diabetes, globally in a range of formulations. While attention has mainly been on the aerial plant parts, there are only a few review studies to date that are focused on the natural constituents present in the plant roots with health benefits. Thus, the present study was performed to review in vivo studies investigating th

Impacts of climate change and anthropogenic activities on vegetation change : Evidence from typical areas in China

Understanding the interactions of climate-vegetation and human-vegetation has been a critical issue and increasingly attracting attention from scientific community in the field of global change research. This study investigated the heterogeneous impacts of climate change and anthropogenic activities on vegetation change by applying the trend analysis and Geodetector approach. The spatial and tempo

A new way of working. Professionals' expectations and experiences of the Culture and Health project for clients with mental disorders

A new way of working with complementary interventions was developed and conducted in a county in Sweden. The intervention, Culture and Health, was directed to adult clients with mental disorders and offered cultural, nature-assisted and physical activities once a week during 14 weeks. Implementation of new interventions might be challenging and one barrier might be the professionals (Grol & Gr

Funktionell familjeterapi (FFT) på ett socialkontor : En kvalitetsgranskning och en forskningsutvärdering.

Studien omfattade 124 ungdomar, 68 flickor och 56 pojkar, medelålder 15,3 år, som behandlades med FFT på ett socialkontor. Studien hade en pre – post - post design. Terapin pågick i 5 - 7 månader med i genomsnitt 13 sessioner, 89 % fullföljde behandlingen. Terapeuterna fick kontinuerligt handledning och certifierades flera gånger. De bedömdes därför vara programföljsamma. Mödrar och fäder samt ung

Attitudes of administrative decision‑makers towards nature‑based solutions for flood risk management in Germany

Over the last two decades, alternative and holistic concepts, such as Nature-based Solutions (NbS) were introduced and adopted by policy-makers, including to the field of flood protection, thereby causing a paradigm shift towards flood risk management. The inclusion of natural water retention measures (NWRM) such as dike relocation and floodplain restoration into the German guidelines for flood pr

Targeted acetylation of wood : a tool for tuning wood-water interactions

Abstract: Wood is an increasingly important material in the sustainable transition of societies worldwide. The performance of wood in structures is intimately tied to the presence of moisture in the material, which directly affects important characteristics such as dimensions and mechanical properties, and indirectly its susceptibility to fungal decomposition. By chemical modification, the durabil

Are migrants in/from emerging economies more entrepreneurial than natives?

The academic debate in migrant entrepreneurship has mainly focused on movements from emerging economies into developed economies. Anecdotal evidence has suggested that the highest impact is generated by migrants in/from emerging economies. To extend this academic discussion in the Latin-American context, this study investigates why migrants are more entrepreneurial than natives. By adopting the hu

Rewetting Intensity Influences Soil Respiration and Nitrogen Availability

It is not clear how different rewetting intensities (rapid, slow or partial rewetting) influence soil respiration and nitrogen (N) availability. Moist soil left unamended or amended with low C/N faba bean residue and incubated for 21 days was dried to rapid > partial rewetting. From day 4 onwards, moisture treatments differed little in respiration rate. In unamended soils, the rewetting intensity

General Trends in Core-shell Preferences for Bimetallic Nanoparticles

Core-shell nanoparticles have gathered much attention of the scientific community owing to their potential applications in various fields including biomedical imaging and catalysis. Predicting core-shell preference1-3 is, however, still largely based on a few experimental observations and limited theorical studies, and hence development of new core-shell nanoparticles is normally built on a trial-

Sticky Wages and the Great Depression: Evidence from the United Kingdom

How sticky were wages during the Great Depression? Although classic accounts emphasize the importance of nominal rigidity in amplifying deflationary shocks, the evidence is limited. In this paper, I calculate the degree of nominal wage rigidity in the United Kingdom between the wars using new granular data covering millions of wages.I find that nominal wages were more flexible downwards than in mo

T cell receptor (TCR) signaling in health and disease

Interaction of the T cell receptor (TCR) with an MHC-antigenic peptide complex results in changes at the molecular and cellular levels in T cells. The outside environmental cues are translated into various signal transduction pathways within the cell, which mediate the activation of various genes with the help of specific transcription factors. These signaling networks propagate with the help of v