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A novel method for the preparation of molecularly imprinted microspheres has been developed. Theophylline, caffeine, and 17β-estradiol are used as template molecules to demonstrate the generally applicable methodology. In the presence of a template molecule, cross-linking polymerization starting from a dilute solution of methacrylic acid and trimethylolpropane trimethacrylate yields polymer micros
Protein-coding genetic variants that strongly affect disease risk can yield relevant clues to disease pathogenesis. Here we report exome-sequencing analyses of 20,791 individuals with type 2 diabetes (T2D) and 24,440 non-diabetic control participants from 5 ancestries. We identify gene-level associations of rare variants (with minor allele frequencies of less than 0.5%) in 4 genes at exome-wide si
Objectives: Moderate physical activity gains survival. There are, however, several variables that may affect this relationship. In this study, the relationship between moderate physical activity and longevity was investigated, taking into account age, gender, smoking habits, cohabitation status, body mass index, leg strength and balance, education level and cognitive function. Method: A sample of
The history of commercial exploitation of fish stocks is replete with instances of over-exploitation and stock collapse. Particularly in situations where little is known about a species or a particular fish stock, unregulated expansion into new fisheries may effectively wipe out a species or stock before its existence is even formally recognised or understood. Globally, there has been a strong int
This paper discusses the existence and scope of the morality exception from patentability, in Article 53 (a) of the European Patent Convention. The analysis will look into the history of the provision, debate its rational and interpretation by reference to three examples of technology areas: stem cell research; gene editing and AI/big data analytics.Bioscience innovation has always generated heate
Background and purpose: Hypofractionated radiotherapy of prostate cancer reduces the overall treatment time but increases the per-fraction beam-on time due to the higher fraction doses. This increased fraction treatment time results in a larger uncertainty of the prostate position. The purpose of this study was to investigate the effect of prostate motion during flattening filter free (FFF) Volume
In this article I conceptualise BDSM (Bondage, Domination and Submission, Discipline, Sadism and Masochism) practices within the frame of contemporary intimacies. This article draws from an empirical research in Milan, involving qualitative interviews and participant observations. Initially, I present a definition of BDSM drawn from contemporary sociological and anthropological literature. Then, I
We present a clinical distance measure for Pareto front evaluation studies in radiotherapy, which we show strongly correlates (r = 0.74 and 0.90) with clinical plan quality evaluation. For five prostate cases, sub-optimal treatment plans located at a clinical distance value of >0.32 (0.28–0.35) from fronts of Pareto optimal plans, were assessed to be of lower plan quality by our (12) observers (p
Uttered Expectations was a reading event performed 27 June 2013, as part of a PhD project at the Department of Architecture, Lund University. Within the frame of the PhD project a series of research interventions were pursued about the establishing of a large-scale science park in an agrarian area just outside the city of Lund, Sweden. In Uttered Expectations written comments from participants tha
Since the 1990s, researchers have presented compelling links between reduced accessibility, transport disadvantage and social exclusion. This evidence has seen the transport equity policy agenda gain momentum in both the transport research and policy discourses. In tandem with this trend has come an increasing focus on accessibility to out-of-home activities as opposed to realised mobility in term
Background and aim: Pain is common in older adults, but its relationship with ageing is unclear. The aim was toinvestigate pain among adults aged 72 years and older by means of a population-based sample followed for aperiod of nine years.Methods: The Swedish National study on Aging and Care (SNAC) is conducted at four research centres. AtSNAC-Blekinge (B), 609 (60.6%) women and 396 (39.4%) men wer
