Crystal structure of lactose and a novel ligand in complex with galectin-8N
The project’s focus is on the protein galectin-8N and crystallizing it with lactose and a novel ligand, MH1. The question for the project comes from previous work that shows that galectin-8N has an empty pocket on the surface of the protein. A novel ligand was designed to improve the affinity to the protein through potential interactions between the chlorophenyl group in the ligand and a pocket on
