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The crystal structure of peroxymyoglobin generated through cryoradiolytic reduction of myoglobin compound III during data collection

Myoglobin has the ability to react with hydrogen peroxide, generating high-valent complexes similar to peroxidases (compounds I and II), and in the presence of excess hydrogen peroxide a third intermediate, compound III, with an oxymyoglobin-type structure is generated from compound II. The compound III is, however, easily one-electron reduced to peroxymyoglobin by synchrotron radiation during cry

Stability of peptide-HLA-I complexes and tapasin folding facilitation - tools to define immunogenic peptides

Only a small fraction of the peptides generated inside the cell end up being presented by HLA-I on the cell surface. High stability of peptide-HLA-I complexes and a low HLA-I tapasin-facilitation have been proposed to predict immunogenicity. We here set out to investigate if these parameters correlated and defined immunogenic peptides. Both peptide-HLA-B*08:01 and peptide-HLA-A*02:01 complexes sho

The association of education with long-term weight change in the EPIC-PANACEA cohort

BACKGROUND/OBJECTIVES: Cross-sectionally, educational attainment is strongly associated with the prevalence of obesity, but this association is less clear for weight change during adult life. The objective of this study is to examine the association between educational attainment and weight change during adult life in the European Prospective Investigation into Cancer and Nutrition (EPIC). SUBJECT

First-principles calculations of dynamical screened interactions for the transition metal oxides MO (M = Mn, Fe, Co, Ni)

To facilitate reliable and accurate modeling of the late transition metal oxides from first principles, we present detailed and systematic calculations of the dynamical screened Coulomb interactions (Hubbard U) of MnO, FeO, CoO, and NiO within the constrained random-phase approximation. The matrix elements of the screened interactions are calculated in maximally localized Wannier functions. We con

Rektorn och arkeologen som utforskade Jonstorps stenålder : Oskar Lidéns forskning är fortfarande betydelsefull

I Jonstorps socken finns flera av de mest välkända stenåldersplatserna inom Skandinavien. De är uppmärksammade både nationellt och internationellt. Det är tack vare rektorn och arkeologen Oskar Lidén (1870–1957), som vi känner till dem. Han gjorde systematiska inventeringar och samlade in ett mycket stort stenåldersmaterial mellan åren 1910 och 1937. Han skrev många artiklar och böcker om fyndplat

On angular ordering in medium-induced radiation

Medium-induced gluon radiation gives rise to the strong energy loss observed in single hadron spectra in heavy ion collisions. Its angular structure, leading e.g. to intra-jet correlations, is only known for the one-gluon inclusive case. In the vacuum, properties such as angular ordering appear when considering less inclusive distributions due to destructive interference effects. We present a calc

The ATLAS TRT barrel detector

The ATLAS TRT barrel is a tracking drift chamber using 52,544 individual tubular drift tubes. It is one part of the ATLAS Inner Detector, which consists of three sub-systems: the pixel detector spanning the radius range 4 to 20 cm, the semiconductor tracker (SCT) from 30 to 52 cm, and the transition radiation tracker ( TRT) from 56 to 108 cm. The TRT barrel covers the central pseudo-rapidity regio

Deviation from quark number scaling of the anisotropy parameter v(2) of pions, kaons, and protons in Au+Au collisions at root s(NN)=200 GeV

Measurements of the anisotropy parameter v(2) of identified hadrons (pions, kaons, and protons) as a function of centrality, transverse momentum p(T), and transverse kinetic energy KET at midrapidity (vertical bar eta vertical bar < 0.35) in Au + Au collisions at root s(N N) = 200 GeV are presented. Pions and protons are identified up to p(T) = 6 GeV/c, and kaons up to p(T) = 4 GeV/c, by combining

Volgo-Uralia: The First U-Pb, Lu-Hf and Sm-Nd Isotopic Evidence of Preserved Paleoarchean Crust

The crustal segment Volgo-Uralia is the least known part of the East European Craton. Its crystalline crust is hidden beneath a thick Neoproterozoic to Phanerozoic cover but disclosed by thousands of drill holes. In conjunction with the recent "Tatseis" reflection seismic profile, we conducted the first isotopic study of the Bakaly granitoid block in eastern Volgo-Uralia, which represents a subsur

Energy Fluctuations Shape Free Energy of Nonspecific Biomolecular Interactions

Understanding design principles of biomolecular recognition is a key question of molecular biology. Yet the enormous complexity and diversity of biological molecules hamper the efforts to gain a predictive ability for the free energy of protein-protein, protein-DNA, and protein-RNA binding. Here, using a variant of the Derrida model, we predict that for a large class of biomolecular interactions,

Moderate mitral regurgitation in patients undergoing CABG - the MoMIC trial

Background. The presence of mild to moderate ischemic mitral regurgitation (IMR) marks a significantly reduced long-term survival and increased hospitalizations due to heart-failure. However, it is common practice in many institutions to refrain from repairing the mitral valve in these patients. There are no available conclusive data to support this practice, and thus there is a need for an adequa

The Artisanal Perspective in Action : An Archaeology in Practice

In what way can an artisanal perspective and artisanal knowledge contribute to current archaeology? How can theories about skill and expertise explain and affect research on artisanal issues? These are the questions that are in focus and have been explored in the four collected papers and in the concluding article in this thesis. The author proposes an artisanal perspective from an interdisciplina

The fourth generation broadband concept

Fixed-broadband access technology is evolving from exclusively copper-based solutions to hybrid fiber-copper architectures. This article presents the expected next step in the evolution of broadband systems, which we call the fourth-generation broadband concept. It identifies a technical, infrastructural, and economical niche and describes how the fiber-access network is extended and forked to fee

Hustadt, Inshallah : Learning from a participatory art project in a trans-local neighbourhood

My PhD dissertation investigates relationships between contemporary art and spatial practices It emphasising the creation of platforms for public participation as interventions into urban regeneration processes. The project has two essential objectives: a. To identify the potential within contemporary art for a critical analysis of an urban de velopment process from the location, in dialogue with

Accurate Predictions of Nonpolar Solvation Free Energies Require Explicit Consideration of Binding-Site Hydration

Continuum solvation methods are frequently used to increase the efficiency of computational methods to estimate free energies. In this paper, we have evaluated how well such methods estimate the nonpolar solvation free-energy change when a ligand binds to a protein. Three different continuum methods at various levels of approximation were considered, viz., the polarized continuum model (PCM), a me

Condensation of DNA using poly(amido amine) dendrimers: effect of salt concentration on aggregate morphology

The condensation of DNA and poly(amido amine) dendrimers of generation 1, 2, 4, 6, and 8 has been studied as a function of salt concentration in order to reveal the forces that control the aggregate size and morphology. For the lower generation dendrimers (1, 2, and 4) a dramatic increase in aggregate size occurs as a result of an increase in salt concentration. Toroidal aggregates having an outer