Whole-body glucose homeostasis is coordinated through secretion of glucagon and insulin from pancreatic islets. When glucose is low, glucagon is released from a-cells to stimulate hepatic glucose production. However, the mechanisms that regulate glucagon secretion from pancreatic a-cells remain unclear. Here we show that in a-cells, the interaction between fatty acid oxidation and glucose metaboli

Importance: Despite some promising preclinical and clinical data, it remains uncertain whether remote ischemic conditioning (RIC) with transient cycles of limb ischemia and reperfusion is an effective treatment for acute stroke. Objective: To evaluate the effect of RIC when initiated in the prehospital setting and continued in the hospital on functional outcome in patients with acute stroke. Desig

Some new interpolation inequalities are obtained in terms of maximal functions that measure smoothness. The results generalize a wide class of recent and classical inequalities and are valid for functions belonging to larger spaces (such as Triebel spaces).

We prove a Galiardo-Nirenberg type pointwise interpolation inequality for special maximal functions which measure smoothness in the multidimensional case. It turns out that the classsical inequality follows from this one; it is also possible to use naturally BMO norms in the inequality. Bibliography: 6 titles.

Why are Nordic sociologists not providing diagnoses of society these days? What has happened to our desire to describe the wider sociocultural currents of the world we live in? Where indeed are the present-day Danish Sennett, the Finnish Rosa, or the Swedish Bauman? These questions resurface now and again, yet without gaining substantial traction. Even so, present-day Nordic sociology is in many w

Barriers to healthcare for men who have sex with men (MSM) in sub-Saharan Africa (SSA) are rooted in stigma and discrimination against MSM fuelled by the criminalization of homosexuality. These barriers are influenced by factors involving MSM and the healthcare workers (HCWs). MSM are uncomfortable disclosing their identities and conceal symptoms of sexually transmitted infections (STIs), especial

Limited research has assessed whether sports participation can be linked to decreasing risky sexual behavior among adolescent girls in sub-Saharan Africa. The current study aimed to assess whether participation in a football league that provides sexual and reproductive health and rights lessons before each football match strengthened adolescent Zambian girls’ sexual health knowledge, attitudes, an

Det är viktigt att förstå att rättigheter kan etableras och utvecklas i en viss tid, för att i en annan tid utmanas, urholkas och ersättas av skyldigheter. Olika rättighetskategorier kan få olika tyngd i förhållande till varandra. Ett exempel belyses i detta kapitel, om de mänskliga rättigheternas framväxt i ett internationellt sammanhang. Bland annat behandlar kapitlet hur det kommer sig att ekon

BackgroundDigital applications that automatically extract information from electronic medical records and provide comparative visualizations of the data in the form of quality indicators to primary care practices may facilitate local quality improvement (QI). A necessary condition for such QI to work is that practices actively access the data. The purpose of this study was to explore the use of an

Background: Hypertension is the leading risk factor for cerebral small vessel disease. We aimed to determine whether antihypertensive drug classes differentially affect microvascular function in people with small vessel disease. Methods: We did a multicentre, open-label, randomised crossover trial with blinded endpoint assessment at five specialist centres in Europe. We included participants aged

MÖNCH is a 25 mm-pitch charge-integrating detector aimed at exploring the limits of current hybrid silicon detector technology. The small pixel size makes it ideal for high-resolution imaging. With an electronic noise of about 110 eV r.m.s., it opens new perspectives for many synchrotron applications where currently the detector is the limiting factor, e.g. inelastic X-ray scattering, Laue diffrac

Investigating the influence of the tidal regime on harbour porpoise Phocoena phocoena distribution in Mount’s Bay, Cornwall Abstract Unintentional by-catch in fishing gear is a significant cause of mortality of harbour porpoises in UK waters. Understanding the spatial distribution of harbour porpoises at fine scales and how this changes over time is essential when trying to understand where thes

Conventional dialyzer membranes typically comprise of unevenly distributed polydisperse, tortuous, rough pores, embedded in relatively thick ≈20–50 µm polymer layers wherein separation occurs via size exclusion as well as differences in diffusivity of the permeating species. However, transport in such polymeric pores is increasingly hindered as the molecule size approaches the pore dimension, resu

Small-angle x-ray scattering tensor tomography provides three-dimensional information on the unresolved material anisotropic microarchitecture, which can be hundreds of times smaller than an image pixel. We develop a direct filtered back-projection method based on algebraic filters that enables rapid tensor-tomographic reconstructions and is a few orders of magnitude faster compared to established

Combining highly efficient nanophotonic structures into artificial neural networks hold significant promise for superior hardware solutions [1]. Well-defined circuit architectures and concepts, with limited size and clear functionality are useful to develop and verify such novel concepts. Insects are capable of amazing autonomous feats well beyond current computers, such as navigating across hundr

Microstructural information over an entire sample is important to understand the macroscopic behaviour of materials. X-ray scattering tensor tomography facilitates the investigation of the microstructural organisation in statistically large sample volumes. However, established acquisition protocols based on scanning small-angle X-ray scattering and X-ray grating interferometry inherently require l