Background and Purpose: In recent years, the treatment landscape for breast cancer has undergone significant advancements, with the introduction of several new anticancer agents. One such agent is trastuzumab emtansine (T-DM1), an antibody drug conjugate that has shown improved outcomes in both early and advanced breast cancer. However, there is currently a lack of comprehensive evidence regarding

The degree of inequality in a society may be harmful to individual health, regardless of wheresomeone is located in the income ladder. An underlying assumption in the literature is thatthere is an instant link between income inequality and individual health and most studiesconsider a contemporary correlation, assessing inequality and health just about the same pointin time. Moreover, research is l

Increasingly, buildings are becoming complex “systems of systems” with many materials and attributes combining to create a whole that aims to meet a variety of design objectives including but not limited to functionality, aesthetic appeal, sustainability, safety, and security. We are now seeing this complexity move from commercial buildings and iconic structures to encompass even the residential s

Galectins play biological roles in immune regulation and tumor progression. Ligands with high affinity for the shallow, hydrophilic galectin-3 ligand binding site rely primarily on a galactose core with appended aryltriazole moieties, making hydrophobic interactions and π-stacking. We designed and synthesized phenyl sulfone, sulfoxide, and sulfide-triazolyl thiogalactoside derivatives to create af

Previous work has shown that exposure to auditory white noise (WN) can improve cognitive performance in children with ADHD, but it is unknown whether this improvement generalizes to other sensory modalities. To address this knowledge gap, we tested the effect of Stochastic Vestibular Stimulation (SVS) on cognitive performance and reaction time (RT) variability in two groups: children with ADHD and

In extreme ultraviolet spectroscopy, the photoionization process occurring in a molecule due to the absorption of a single photon can trigger an ultrafast nuclear motion in the cation. Taking advantage of attosecond photoelectron interferometry, where the absorption of the extreme ultraviolet photon is accompanied by the exchange of an additional infrared quantum of light, one can investigate the

Nanoplastics (NPs) originated from plastic residues can interact with soil microorganisms with potential negative effects to their functions. Therefore, I aimed to investigate soil microbial population dynamics when exposed to different NP polymers and concentrations. I used microfluidics technology to produce a soil micromodel – a soil chip - comprising basic pore geometries where microorganisms

This paper presents an overview of animals depicted within the Swedish concession area of Gebel el-Silsila and Shatt el-Rigal, spanning the Prehistoric tothe early Islamic period. It includes commentaries on stylistic, technical andchronological phases of the rock art, and present an overview of distributionpatterns as well as a relative taxonomic morphology for the more frequentmotifs. Main emphaThis paper presents an overview of animals depicted within the Swedish con-cession area of Gebel el-Silsila and Shatt el-Rigal, spanning the Prehistoric to the early Islamic period. It includes commentaries on stylistic, technical and chronological phases of the rock art, and present an overview of distribution patterns as well as a relative taxonomic morphology for the more frequent motifs. Main

Protein assemblies are some of the most complex molecular machines in nature. They facilitate many cellular functions, from DNA replication to molecular motion, energy production, and even the production of other proteins. In a series of 3 papers, we analyzed the structure, developed structure prediction tools, and design tools, for different protein assemblies. Many of the studies were centered a

Legal tech is growing, and its growth provokes anxieties about the future of the legal profession as such. In this article, we examine the impact of legal tech on the central role of lawyers at law firms in crafting an imagined ‘right legal answer’ by drawing on Duncan Kennedy’s suggestion that a claim to the rightness of one’s legal propositions is a central characteristic of the legal profession

While it is widely acknowledged that entrepreneurial processes are embedded in an institutional framework, understanding exactly how institutions impact Entrepreneurial Ecosystems (EEs) remains a challenge. This is especially the case for informal institutions, and in particular those not directly related to entrepreneurship support. This paper contributes to this gap by addressing the question: H

During the recent years, the question of whether an Entrepreneurial Ecosystem emerges organically or is man-made has been disputed. This paper explores the case of an Entrepreneurial Ecosystem in a developing country. We argue that in the context of lagging industrial development and weak institutions, a lead actor needs to step in to aid the emergence of an Entrepreneurial Ecosystem. We argue tha

Technological innovation is still a challenge for SMEs in emerging countries, mainly due to the lack of financial, structural, capital, and proper managerial resources. Covid-19 presented a scenario that increased difficulties for companies, especially of this kind, and at the same time presented a necessity-driven impulse to look for innovative solutions. This study aimed to analyze the drivers o

Nowadays, numerous specialized systems, ranging from electronics to energy production processes can be found both in science and industry. However due to their specialized nature they often exhibit high sensitivity to intrusive measurements, which can potentially perturb the sought-after characteristics or quantity and consequently compromise overall accuracy. In these scenarios, optical measureme