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Intestinal gluconeogenesis is downregulated in pediatric patients with celiac disease

Background: Untreated celiac disease (CD) patients have increased levels of blood glutamine and a lower duodenal expression of glutaminase (GLS). Intestinal gluconeogenesis (IGN) is a process through which glutamine is turned into glucose in the small intestine, for which GLS is crucial. Animal studies suggest impaired IGN may have long-term effects on metabolic control and be associated with the

Pharmacological interventions for pain and sedation management in newborn infants undergoing therapeutic hypothermia

Background: Newborn infants affected by hypoxic-ischemic encephalopathy (HIE) undergo therapeutic hypothermia. As this treatment seems to be associated with pain, and intensive and invasive care is needed, pharmacological interventions are often used. Moreover, painful procedures in the newborn period can affect pain responses later in life, impair brain development, and possibly have a long-term

Direct Observation of Size-Dependent Phase Transition in Methylammonium Lead Bromide Perovskite Microcrystals and Nanocrystals

Methylammonium (MA) lead halide perovskites have been widely studied as active materials for advanced optoelectronics. As crystalline semiconductor materials, their properties are strongly affected by their crystal structure. Depending on their applications, the size of MA lead halide perovskite crystals varies by several orders of magnitude. The particle size can lead to different structural phas

SARS-CoV-2 spike protein aggregation is triggered by bacterial lipopolysaccharide

SARS-CoV-2 spike (S) protein is crucial for virus invasion in COVID-19. Here, we showed that lipopolysaccharide (LPS) can trigger S protein aggregation at high doses of LPS and S protein. We demonstrated the formation of S protein aggregates by microscopy analyses, aggregation and gel shift assays. LPS at high levels boosts the formation of S protein aggregates as detected by amytracker and thiofl

Thermal conductivity of AlxGa1−xN (0≤x≤1) epitaxial layers

AlxGa1−xN ternary alloys are emerging ultrawide band gap semiconductor materials for high-power electronics applications. The heat dissipation, which mainly depends on the thermal conductivity of the constituent material in the device structures, is the key for device performance and reliability. However, the reports on the thermal conductivity of AlxGa1−xN alloys are very limited. Here, we pr

Mg segregation at inclined facets of pyramidal inversion domains in GaN:Mg

Structural defects in Mg-doped GaN were analyzed using high-resolution scanning transmission electron microscopy combined with electron energy loss spectroscopy. The defects, in the shape of inverted pyramids, appear at high concentrations of incorporated Mg, which also lead to a reduction in free-hole concentration in Mg doped GaN. Detailed analysis pinpoints the arrangement of atoms in and aroun

Mycotoxin Exposure and Renal Cell Carcinoma Risk : An Association Study in the EPIC European Cohort

Background: Mycotoxins have been suggested to contribute to a spectrum of adverse health effects in humans, including at low concentrations. The recognition of these food contaminants being carcinogenic, as co-occurring rather than as singularly present, has emerged from recent research. The aim of this study was to assess the potential associations of single and multiple mycotoxin exposures with

Electrical Tuning of Plasmonic Conducting Polymer Nanoantennas

Nanostructures of conventional metals offer manipulation of light at the nanoscale but are largely limited to static behavior due to fixed material properties. To develop the next frontier of dynamic nano-optics and metasurfaces, this study utilizes the redox-tunable optical properties of conducting polymers, as recently shown to be capable of sustaining plasmons in their most conducting oxidized

Unaided efficient transglutaminase cross-linking of whey proteins strongly impacts the formation and structure of protein alginate particles

There is a dogma within whey protein modification, which dictates the necessity of pretreatment to enzymatic cross-linking of β-lactoglobulin (β-Lg). Here microbial transglutaminase (MTG) cross-linked whey proteins and β-Lg effectively in 50 mM NaHCO3, pH 8.5, without pretreatment. Cross-linked β-Lg spanned 18 to >240 kDa, where 6 of 9 glutamines reacted with 8 of 15 lysines. The initial isopeptid

Unveiling the role of Ag-Sb bimetallic S-scheme heterojunction for vis-NIR-light driven selective photoreduction CO2 to CH4

The construction of interfacial engineered heterojunctions is an effective strategy to broaden the optical response and facilitate charge separation. Herein, a novel 0D/1D Ag2S/Sb2S3 heterojunction is prepared by in-situ growth of Ag2S quantum dots on Sb2S3 nanorods using a simple hydrothermal approach. The 10% Ag2S/Sb2S3 (10AS) heterojunction exhibited efficient CO2 photoreduction activity with a

Minimal Solvers for Point Cloud Matching with Statistical Deformations

An important issue in simultaneous localisation and mapping is how to match and merge individual local maps into one global map. This is addressed within the field of robotics and is crucial for multi-robot SLAM. There are a number of different ways to solve this task depending on the representation of the map. To take advantage of matching and merging methods that allow for deformations of the lo

Kära Sverige: Bli inte för förälskade i den danska kriminalpolitiken!

Svenska politiker har förälskat sig i Danmark. Det gäller åtminstone den danska kriminalpolitiken, som både under och efter valrörelsen har blivit ett slags riktmärke för hur Sverige ska lösa sina stora utmaningar med gängkriminalitet och gängvåld. Precis som våra kära svenska grannar gläds vi danskar åt beröm.

Civil society elites’ challengers in the UK: A frontlash/backlash perspective

Amid growing polarisation in European societies, civil society elites, encompassing resource-rich, influential and often liberal-oriented civil society organisations (CSOs), are under increased attacks by conservative and progressive actors alike. This article aims to understand who challenges civil society elites, on what grounds, and with what means do they do so in the United Kingdom, by drawin

Beskattning av energibranschens vinster

I rapporten analyseras inkomstskatte- och fastighetsbeskattningens betydelse för reinvesteringar i energibranschen. Bl.a. görs beräkningar av skatteuttagen i en jämförande studie med beskattningen av den svenska bolagssektorn. Vidare analyseras kopplingen mellan redovisning och beskattning och uppkomna skattekrediter.

Taurine and N-acetylcysteine treatments prevent memory impairment and metabolite profile alterations in the hippocampus of high-fat diet-fed female mice

Background: Obesity constitutes a risk factor for cognitive impairment. In rodent models, long-term exposure to obesogenic diets leads to hippocampal taurine accumulation. Since taurine has putative cyto-protective effects, hippocampal taurine accumulation in obese and diabetic models might constitute a counteracting response to metabolic stress. Objective: We tested the hypothesis that treatment

Short-term lingonberry feeding is associated with decreased insulin levels and altered adipose tissue function in high-fat diet fed C57BL/6J mice

Intact adipose tissue function is essential to maintain glucose and lipid homeostasis. To study the impact of altered adipose tissue function on whole-body metabolism, diet-induced obesity in mice is frequently used as a model organism. In the current study, we have examined health-promoting effects of a lingonberry supplemented diet. We found C57BL/6J mice fed a high-fat diet supplemented with li

The Islamic Juridical Vacuum and Islamic Authorities' Role in Divorce Cases

This article argues that Islamic authorities do not try to sustain a jurisdiction over Islamic divorce in Denmark. They respond to a juridical demand caused by the absence of Islamic legal institutions in Denmark, which I call the Islamic juridical vacuum. This vacuum entails that sharia is often defined locally in communities or families rather than by Islamic authorities, and when women are unab

The Practice of Two Danish Female Islamic Authorities Facilitating Divorce

Research on Muslim divorce practices in Europe often focuses exclusively on male Islamic authority, neglecting the role of women. This article compares the Islamic divorce practice of two female Islamic authorities with that of nineteen male Islamic authorities to demonstrate that women have important roles in relation to Islamic divorce. It also analyses how the two Danish female informants, Zayn