Lung-resident mesenchymal stem cells (LR-MSC) are thought to participate in idiopathic pulmonary fibrosis (IPF) by differentiating into myofibroblasts. On the other hand, LR-MSC in IPF patients present senescence-related features. It is unclear how they respond to a profibrotic environment. Here, we investigated the profibrotic response of LR-MSC isolated from IPF and control (CON) patients. LR-MS

We prove that polynomial calculus (and hence also Nullstellensatz) over any field requires linear degree to refute that sparse random regular graphs, as well as sparse Erdős-Rényi random graphs, are 3-colourable.

We prove that unary Sherali-Adams requires proofs of size nΩ(d) to rule out the existence of an nΘ(1)-clique in Erdős-Rényi random graphs whose maximum clique is of size d ≤ 2 log n. This lower bound is tight up to the multiplicative constant in the exponent. We obtain this result by introducing a technique inspired by pseudo-calibration which may be of independent interest. The technique involves

Biomarkers in Cancer Detection and Monitoring of Therapeutics, Volume One, Discovery and Technologies discusses how molecular biomarkers are used to determine predisposition, facilitate detection, improve treatment and offer prevention guidelines for different cancer types. This first volume in the series focuses on techniques and approaches recently developed to assist in the decision of which bi

The thesis presented here delves into why dwell time delays for commuter trains occur, with a specific focus on the impact of boarding and alighting passengers. The overarching aim is to develop knowledge of how time delays arise to identify and describe potential ways in which dwell time delays can be reduced. In addition to this, a secondary aim is to identify how dwell times can be studied on a

A recent meta-analysis on the political impact of the Sustainable Development Goals (SDGs) has shown that these global goals are moving political processes forward only incrementally, with much variation across countries, sectors and governance levels. Consequently, the realization of the 2030 Agenda for Sustainable Development remains uncertain. Against this backdrop, this article explores where

The successful economic performance of Pacific Asia is often held as a source of inspiration for aspiring catching-up countries. Notwithstanding, recent literature suggests that a key to the understanding of successful long-term economic performance lies not only in the ability to generate economic growth, but in limiting incidences of economic shrinking. Such analyses to explain the Asian economiThe successful economic performance of Pacific Asia is often held as a source of inspiration for aspiring catching-up countries. Notwithstanding, recent literature suggests that a key to the understanding of successful long-term economic performance lies not only in the ability to generate economic growth, but in limiting incidences of economic shrinking. Such analyses to explain the Asian economi

Around the world, paid work without appropriate structural support is a key barrier to optimal breastfeeding practices. To better protect, promote, and support optimal breastfeeding practices among working women in Africa, this scoping review sought to understand how paid work influences infant feeding practices in the first 6 mo of life and what support women need to manage work and optimal infan

Adherence to antiretroviral therapy is a global problem among adolescents living with human immunodeficiency viruses (HIV), and it is associated with treatment failure and the development of viral resistance. One of the most significant barriers to treatment adherence among adolescents is forgetting to take drugs as prescribed. One of the key strategies recommended to improve this problem is the u

Nemacheilid fishes in the genus Turcinoemacheilus are physically small members of the ichthyofauna communities of high-altitude and mountainous freshwater ecosystems. They are all distributed in Western Asia apart from a single species, described in the Himalayas. They are usually very similar in appearance, which complicates their proper identification and/or description. This is why it is import

St. Birgitta of Sweden (d. 1373) is one of the most celebrated female visionaries and authors of the Middle Ages and a central figure in the history of late-medieval religion. An aristocratic widow, Birgitta left her native country in 1349 and settled in Rome, where she established herself as an outspoken critic of the Avignon Papacy and an advocate of spiritual and ecclesiastical reform. Birgitta

Under global warming, flooding has become one of the most destructive natural disasters along the China–Pakistan Economic Corridor (CPEC), which significantly jeopardizes the construction and ongoing stability of the CPEC. The assessment of regional flood potential is, therefore, crucial for effective flood prevention and relief measures. In light of this, our study applied MIKE 11 hydrodynamic mo

Background: Factors that influence outcomes of interdisciplinary pain rehabilitation programs (IPRP) are poorly known. It is unclear how outcomes are influenced by pain intensity, psychological distress, and coping strategies. Aim: This clinical registry-based longitudinal cohort study has three aims: 1) to determine the relative importance of pain intensity, psychological distress, acceptance, an

The degree of mass loss, that is the fraction of stars lost by globular clusters, and specifically by their different populations, is still poorly understood. Many scenarios of the formation of multiple stellar populations, especially the ones involving self-enrichment, assume that the first generation (FG) was more massive at birth than now in order to reproduce the current mass of the second gen

A decline in hematopoietic stem cell (HSC) function is believed to underlie hematological shortcomings with age; however, a comprehensive molecular understanding of these changes is currently lacking. Here we provide evidence that a transcriptional signature reported in several previous studies on HSC aging is linked to stress-induced changes in gene expression rather than aging. Our findings have

In this paper, we explore cybersecurity from a sociotechnical work-system perspective and focus on the visibility and effectiveness of security practices as part of the everyday work practices of typical employees. The empirical inquiry involved 471 employees from 259 different organizations, drawn from both private and public sectors using semi-structured interviews and conducted from an interpre