Geospatial information is indispensable for various real-world applications and is thus a prominent part of today’s data science landscape. Geospatial data is primarily maintained and disseminated through spatial data infrastructures (SDIs). However, current SDIs are facing challenges in terms of data integration and semantic heterogeneity because of their partially siloed data organization. In th

Although fatty acid binding protein 4 (FABP4) may increase risk of diabetes and exert negative cardiac inotropy, it is unknown whether plasma concentrations of FABP4 are associated with incidence of sudden cardiac death (SCD). We prospectively analyzed data on 4,560 participants of the Cardiovascular Health Study. FABP4 was measured at baseline using ELISA, and SCD events were adjudicated through

Glucagon-like peptide-1 (GLP-1) secretion is classically regulated by ingested nutrients. To identify novel molecular targets controlling incretin secretion, we analyzed enteroendocrine cell pathways important for hormone biosynthesis and secretion. We demonstrate that progesterone increases GLP-1 secretion and extracellular signal-related kinase 1/2 (ERK1/2) phosphorylation in enteroendocrine GLU

Objective: To evaluate the effects of vasoactive drugs, specifically low-dose vasopressin and phenylephrine infusions, on blood loss / transfusion requirements during dissection and anhepatic (pre-reperfusion) stages of orthotopic liver transplantations. Methods: A retrospective analysis of 110 orthotopic liver transplantation (OLT) cases was performed. The variables studied were: blood loss befor

Background & Aims: Glucagon-like peptide-2 (GLP-2) is a 33-amino acid peptide hormone secreted by enteroendocrine cells in response to nutrient ingestion. GLP-2 stimulates crypt cell proliferation leading to expansion of the mucosal epithelium; however, the mechanisms transducing the trophic effects of GLP-2 are incompletely understood. Methods: We examined the gene expression profiles and gro

Glucagon-like peptide-1 (GLP-1) is released from intestinal L-cells in response to nutrient ingestion. It is currently under therapeutic evaluation because it enhances insulin secretion in type 2 diabetes. Previous studies using the GLP-1 secreting cell line GLUTag have shown that the cells are electrically active, and that the action potential frequency is regulated by nutrients. In this study we

Three ways of knowing; associative knowing, compositional knowing and contextual knowing are theoretically explored and illustrated. The main implication for mathematics education is that communication needs to focus on students' authorship. Classrooms in India and Sweden are compared and analyzed for these three ways of knowing.

We provide an analysis of a randomly grown 2-d network which models the morphological growth of dendritic and axonal arbors. From the stochastic geometry of this model we derive a dynamic graph of potential synaptic connections. We estimate standard network parameters such as degree distribution, average shortest path length and clustering coefficient, considering all these parameters as functions

Objectives: To investigate survival among elderly residents of Swedish nursing homes (NHs), with specific focus on those with two or more signs of Lewy body dementia (LBD). Design: Prospective observational study. Setting: NHs in Malmö, the third largest city in Sweden. Participants: The study population was older adults (aged ≥65 years) living in the 40 NHs in Malmö. Clinical data were collected

Background:Continuous flow peritoneal dialysis (CFPD) is performed using a continuous flux of dialysis fluid via double or dual-lumen PD catheters, allowing a higher dialysate flow rate (DFR) than conventional treatments. While small clinical studies have revealed greatly improved clearances using CFPD, the inability to predict ultrafiltration (UF) may confer a risk of potentially harmful overfill

Emotional vocabulary and symbols on social media abound, not only in private communication, but also in organizations and workplace organizing. In this paper, we argue that emotional labor driven by technical developments is an important but hitherto rather overlooked dark side of digitalization. We thereby take a critical perspective on the techno-utopian literature of social media organizing, by