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The First Date: an Investor Pitch

Forskningsfråga: Vilka investeringskriterier bedömer investeringsansvariga i riskkapitalbolag i en pitch och hur påverkar informationen i pitchen deras beslutsfattande? Syfte: Att undersöka och kontextualisera vilka investeringskriterier riskkapitalister bedömer i de olika nivåerna av en pitch och analysera effekten av informationen som presenteras i pitchen på deras beslutsfattande. Metod: En kResearch question: What investment criteria in a pitch do managers of venture capital firms assess and how does the information presented in the pitch affect their decision-making? Purpose: To examine and contextualize what investment criteria venture capitalists assess in the different levels of a pitch and analyze the effect of the information presented in the pitch on their decision-making. M

Cultural Adaptation of Interventions and the a Priori Assessment of Intervention Fit : Exploring Measurement Invariance for American and Swedish Youth Leaving Care

Purpose: There is a growing literature on the importance of cultural adaptation of research-supported social work interventions. Few studies have however offered systematic methods for the a priori assessment of intervention fit in a new context. The current study explores the use of measurement invariance analyses to help identify whether key theoretical constructs in an intervention’s theory of

A dose planning study for cardiac and lung dose sparing techniques in left breast cancer radiotherapy : Can free breathing helical tomotherapy be considered as an alternative for deep inspiration breath hold?

Purpose: To investigate the possibility to be able to offer left sided breast cancer patients, not suitable for DIBH, an organ at risk saving treatment. Materials and Methods: Twenty patients receiving radiotherapy for left breast cancer in DIBH were enrolled in the study. Planning CT scans were acquired in the same supine treatment position in FB and DIBH. 3DCRT_DIBH plans were designed and optim

Protocol for optical clearing and imaging of fluorescently labeled ex vivo rat brain slices

Tissue clearing is commonly used for whole-brain imaging but seldom used for brain slices. Here, we present a simple protocol to slice, immunostain, and clear sections of adult rat brains for subsequent high-resolution confocal imaging. The protocol does not require toxic reagents or specialized equipment. We also provide instructions for culturing of rat brain slices free floating on permeable cu

The TESS-Keck Survey. XI. Mass Measurements for Four Transiting Sub-Neptunes Orbiting K Dwarf TOI-1246

Multiplanet systems are valuable arenas for investigating exoplanet architectures and comparing planetary siblings. TOI-1246 is one such system, with a moderately bright K dwarf (V = 11.6, K = 9.9) and four transiting sub-Neptunes identified by TESS with orbital periods of 4.31, 5.90, 18.66, and 37.92 days. We collected 130 radial velocity observations with Keck/HIRES and TNG/HARPS-N to measure pl

A matter of timing : System requirements for repair and their temporal dimensions

Research into repair within the circular economy (CE) typically focuses on technical aspects of design, policy, and markets, and often assumes simplified conditions for the user/owner and the product system to explain the barriers to scaling repair activities. However, factors occurring at pre-use stages of the product's life cycle can significantly influence whether, and to what extent, repair is

In situ quantitative analysis of electrochemical oxide film development on metal surfaces using ambient pressure X-ray photoelectron spectroscopy : Industrial alloys

Ambient Pressure X-ray Photoelectron Spectroscopy combined with an electrochemical setup is used to study, in situ, the electrochemical oxide growth on an industrial Ni-Cr-Mo alloy. The native oxide film was characterized in vacuum and in water vapor at 17 mbar, and was found to be 11.4 Å thick and rich in Cr3+. In 0.1 M NaCl electrolyte, anodic growth of the oxide film at potentials up to 700 mV

Neuronal activity patterns in microcircuits of the cerebellar cortical C3 zone during reaching

Abstract: The cerebellum is the largest sensorimotor structure in the brain. A fundamental organizational feature of its cortex is its division into a series of rostrocaudally elongated zones. These are defined by their inputs from specific parts of the inferior olive and Purkinje cell output to specific cerebellar and vestibular nuclei. However, little is known about how patterns of neuronal acti

Impact of cracks on distribution of chloride-induced reinforcement corrosion

Surface crack width is regulated in codes to limit corrosion of reinforcement bars in concrete. However, the influence of surface crack width on corrosion damages is not directly inferable from previous research.In this work, data on corroded cracked concrete specimens in chloride environments was compiled. Detailed information was included, such as crack and pit locations, local corrosion pattern

Recombinant yeast for production of the pain receptor modulator nonivamide from vanillin

We report on the development of a method based on recombinant yeast Saccharomyces cerevisiae to produce nonivamide, a capsaicinoid and potent agonist of the pain receptor TRPV1. Nonivamide was produced in a two-step batch process where yeast was i) grown aerobically on glucose and ii) used to produce nonivamide from vanillin and non-anoic acid by bioconversion. The yeast was engineered to express

To report or not to report: What happens when middle managers receive bad news about safety issues?

Fascinated and often frustrated, it has often been that the flow of critical safety information is not as fluid and transparent as one would consider reasonable (Westhuizen & Stanz, 2017). This notional concept of ‘reporting’ has been researched and studied from many different industries and perspectives but has yet to answer, why individuals and groups lack the culture necessary to report wha

The injury-induced transcription factor SOX9 alters the expression of LBR, HMGA2, and HIPK3 in the human kidney

Induction of SRY box transcription factor 9 (SOX9) has been shown to occur in response to kidney injury in rodents, where SOX9-positive cells proliferate and regenerate the proximal tubules of injured kidneys. Additionally, SOX9-positive cells demonstrate a capacity to differentiate toward other nephron segments. Here, we characterized the role of SOX9 in normal and injured human kidneys. SOX9 exp

Clinical versus MRI grading of the medial collateral ligament in acute knee injury

Sensitivity, specificity, and agreement between clinical and magnetic resonance imaging (MRI) gradings of the medial collateral ligament (MCL) after acute knee injury were evaluated in 362 patients. Ninety-seven per cent were injured during sports/recreation. Sensitivity and specificity of MRI for grade II or III MCL injury was 68% (95% CI 58–77%) and 90% (95% CI 86–93%), respectively. Weighted Ka

A Serpent in the Garden?

This paper presents Elmar Unnsteinsson’s novel theory of Edenic Intentionalism, on which a speaker cannot refer to an object when the speaker is relevantly confused about its identity. A challenge to the theory is presented and several possible responses considered. The challenge is this: According to Edenic Intentionalism, reference often fails even when speakers seem to refer successfully. Elmar

Nanoscale characterization of collagen structural responses to in situ loading in rat Achilles tendons

The specific viscoelastic mechanical properties of Achilles tendons are highly dependent on the structural characteristics of collagen at and between all hierarchical levels. Research has been conducted on the deformation mechanisms of positional tendons and single fibrils, but knowledge about the coupling between the whole tendon and nanoscale deformation mechanisms of more commonly injured energ