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Rheumatoid arthritis (RA) is a chronic inflammatory disease primarily affecting cartilaginous joints but also extra-articular tissues such as the nose and upper respiratory tract. We have investigated extra-articular cartilage involvement in two commonly used animal models for RA, collagen-induced and pristane-induced arthritis, by immunizing rats with different susceptibility to disease (LEW.1 A,

The complementary employment of two separation techniques, one analytical-scale, the other preparative-scale, i.e. the lift-hyperlayer asymmetrical flow field-flow fractionation (AsyFIFFF) and the split flow-thin cell (SPLITT) is presented for the first time as a methodology to size-separate and rapidly characterize starch granules of different botanical origins. Very rapid separation and size cha

The effect of the application of pulsed electric fields to potato tissue on the diffusion of the fluorescent dye FMI-43 through the cell wall was studied. Potato tissue was subjected to field strengths ranging from 30 to 500 V/cm, with one 1 ms rectangular pulse, before application of FM1-43 and microscopic examination. Our results show a slower diffusion of FM1-43 in the electropulsed tissue when

Direct electrochemistry of heme multicofactor-containing enzymes, e.g., microbial theophylline oxidase (ThOx) and D-fructose dehydrogenase (FDH) from Gluconobacter industrius was studied on alkanethiol-modified gold electrodes and was compared with that of some previously studied complex heme enzymes, specifically, cellobiose dehydrogenase (CDH) and sulphite oxidase (SOx). The formal redox potenti

NMR spin relaxation in the rotating frame (R-1p) is a unique method for atomic-resolution characterisation of conformational (chemical) exchange processes occuring on the microsecond timescale. We present a rotating frame C-13 relaxation dispersion experiment for measuring conformational dynamics in uniformly C-13-labeled proteins. The experiment was validated by using the E140Q mutant of the C-te

A case report of a patient who suffered from a rapidly progressive lung adenocarcinoma with malignant pleural effusions, is given. The patient failed to respond on two series of conventional cytotoxic drug therapy (Carboplatin, Etoposid). Interleukin-2 (IL-2) treatment was first started as intrapleural instillations (3.0 million IU per day in 6 days). A clear clinical response was achieved with ce

This paper presents a finite volume scheme on rectangular and triangular meshes based on a third order accurate logarithmic reconstruction. Several numerical experiments, including the Euler equations for compressible gas dynamics, illustrate the high resolution and non-oscillatory properties of the new scheme.

Hydrogen embrittlement is often a catastrophic phenomenon of machine elements failure under cyclic stresses. This hydrogen is generated as a result of tribo-chemical and mechanical actions on the working surfaces. This hydrogen can have three different zones or stages of behaviour under tribo-mechanical actions. Firstly, it can strongly adsorb on the mating surfaces at a shallow subsurface zone an

Objective: Fibroblast growth factor-23 (FGF23) is a circulating factor involved in phosphate (Pi) and vitamin D metabolism. Serum FGF23 is increased at later stages of chronic kidney disease due to chronic hyperphosphatemia and decreased renal clearance. Recent studies also indicate that FGF23 may directly regulate the expression of parathyroid hormone (PTH) in vitro. Therefore, the objective of t

We discuss the age of the stellar disks in the solar neighborhood. After reviewing the various methods for age dating, we discuss current estimates of the ages of both the thin- and the thick disks. We present preliminary results for kineymatically-selected stars that belong to the thin- as well as the thick disk. All of these dwarf and sub-giant stars have been studied spectroscopically and we ha

1. Recent reviews demonstrate that genetically determined alternative mating strategies (AMS) are widespread and typically consist of morphs that are recognized by morphological or colour traits. Despite well-established behavioural differences associated with each morph, and evidence that androgens are involved in the induction of morphs, few studies have examined whether morphs also vary in whol

Background: The potential doubling time of a tumor has been suggested to be a measurement of tumor aggressiveness; therefore, it is of interest to find reliable methods to estimate this time. Because of variability in length of the various cell cycle phases, stochastic modeling of the cell cycle might be a suitable approach. Methods: The relative movement curve and the DNA synthesis time were esti

The purpose of this study was to assess the association between 2,2',4,4',5,5'-hexachlorobiphenyl (CB-153) in plasma, a biomarker of exposure to polychlorinated biphenyls (PCB), and time to pregnancy (TTP) in a group of women with a varying dietary exposure to PCB. For 121 Swedish east coast fishermen's wives (median year of birth 1956, range 1945-1968), information on selt-reported TTP for the fi

To investigate the influence of sulfonated polysulfone (sPSU) in membrane–electrode assemblies (MEAs), sPSU-based gas diffusion electrodes (GDEs) and sPSU membranes were studied both as complete MEAs and as separate components in assembled MEAs at 60–120°C. The complete sPSU MEAs showed mass-transport limitations, irrespective of ion exchange capacity, compared to Nafion MEAs. Cyclic voltammetry a

Patients with chronic liver impairment often display symptoms of affective psychiatric nature where the choice for antidepressant treatment is rational. Since caution is recommended when these drugs are used in such patients, a dose reduction is usually performed. We have previously reported that a dose reduction to liver-impaired portacaval shunted rats has resulted in similar brain concentration

Macrolides can be clinically effective in chronic rhinosinusitis (CRS). However, little is known about how these drugs affect pathophysiological features of CRS in vivo. In the present study, patients with CRS were subjected to long-term treatment with clarithromycin. Nasal lavages with and without histamine (40 and 400 mu g ml(-1)) were carried out prior to and late into the treatment period. His

Absence of laminin alpha2 chain leads to a severe form of congenital muscular dystrophy (MDC1A) associated with peripheral neuropathy. Hence, future therapies should be aimed at alleviating both muscle and neurological dysfunctions. Pre-clinical studies in animal models have mainly focused on ameliorating the muscle phenotype. Here we show that transgenic expression of laminin alpha1 chain in musc