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Biological Activities of Natural and Semi-Synthetic Pseudo-Guaianolides: Inhibition of Transcription Factors

Popular Abstract in English The sesquiterpene lactones is an important group of natural products, and they are present in many medicinal plants. Their most important biological activities are anti-inflammatory and anti-cancer activity, although for many decades their potential use as drugs was dismissed. The main reason for this was their alkylating capacity, reacting with thiol functions in proteDamsin (1) is a natural sesquiterpene lactone (SL) isolated from Ambrosia arborescens Mill., a plant used in the Andes as antiinflammatory medicine. This natural product is an inhibitor of NF- κB, a protein complex that controls the transcription of many genes in mammalian cells, and has a potential for standing model for the development of new anti-cancer lead structures. In order to improve the

Polymer-Graft-Mediated Interactions between Colloidal Spheres

Aqueous dispersions of fluorinated colloidal spheres bearing grafted poly(ethylene glycol) (PEG) are studied as a function of salt and particle concentration with the aim of improving the understanding of interactions among polymer-grafted particles. These dispersions can sustain large concentrations of salt, but crystals nucleate in dilute dispersions when a sufficient Na2CO3 concentration is rea

BIM Inertia: Contracts & Behaviours

Whilst Building Information Modelling (BIM) promises significant improvements in construction quality and efficiency, current contractual models do not encourage its use; indeed actively inhibit the collaboration at its core. To help bring BIM into the mainstream, it is claimed we need to re-craft existing contractual relationships to facilitate collaborative decision making and to equitably alloc

Numerical Investigation of Methane/Hydrogen/Air Partially Premixed Flames in the SGT-800 Burner Fitted to a Combustion Rig

The Siemens SGT-800 3rd generation DLE burner fitted to an atmospheric combustion rig has been numerically investigated. Pure methane and methane enriched by 80 vol% hydrogen flames have been considered. A URANS (Unsteady Reynolds Averaged Navier-Stokes) approach was used in this study along with the k − ω SST and the k − ω SST-SAS models for the turbulence transport. The chemistry is coupled to t

Evaluation of sub grid scale and local wall models in Large-eddy simulations of separated flow

The performance of the Sub Grid Scale models is studied by simulating a separated flow over a wavy channel. The first and second order statistical moments of the resolved velocities obtained by using Large-Eddy simulations at different mesh resolutions are compared with Direct Numerical Simulations data. The effectiveness of modeling the wall stresses by using local log-law is then tested on a rel

Non-intrusive temperature and oxygen concentration measurements in a catalytic combustor using : Rotational coherent anti-stokes raman spectroscopy

Rotational CARS (Coherent anti-Stokes Raman Spectroscopy) was used to measure temperature and relative oxygen concentrations in the exhaust gas of a catalytic combustor. This laser technique has the general advantages of such techniques, i.e. possibility of performing in-situ measurements with high spatial and temporal resolution, and non-intrusiveness. Profiles of temperature and oxygen concentra

What's Eating the Eater? Perspectives on the Everyday Anxiety of Food Consumption in Late Modernity

Popular Abstract in Swedish Dagens konsumenter översköljes ständigt av en aldrig sinande ström av budskap om vad man ska och inte ska äta för att leva hälsosamt. Detta bombardemang har ökat under de senaste årtiondena då diverse aktörer, så som representanter från hälso- och sjukvårdssektorn och statliga myndigheter, ytterligare har poängterat kopplingarna mellan individers matkonsumtion och derasConsumers today are constantly showered with a vast array of different messages about what and how they should and should not eat in order to lead a healthy life. This bombardment has escalated over the last decades as various actors, such as representatives from the medical community and public policy makers, have increasingly stressed the connections between individuals’ food consumption habits

Body and Authority in Contemporary Art: Tehching Hsieh’s One-Year Performances

The essay examines how contemporary artists directly or indirectly violate laws not only in order to create art, but also to break into—and become recognised by—the artworld. It first discusses two much-debated Swedish artworks—Lars Norén’s play Seven Three (1998) and Anna Odell’s Unknown, woman 2009-349701 (2009)—that have brought about confrontations between individuals and social institutions.

The Importance of Form Field Validation : Lesson Learnt From a Feasibility Study of an M-Health Application in Malawi, Africa

Measuring adherence to clinical guidelines using mobile health (mHealth) technologies when form field validation is enforced or turned on could potentially be viewed as skewing the dataset, leading to 100% adherence to the clinical rule base. In theory, healthcare providers should fully abide by clinical guidelines, whether in paper or digital format, to ensure that the patient receives appropriat

Co-constructing Contextual Theory : An Experience within IS Education Domain

Reviewing the information systems (IS) literature shows the prevalence of studies claiming to exploit the grounded theory (GT) method. However, most of these studies follow an objectivist approach to GT. This manuscript addresses another recognized yet rarely used GT approach in IS: constructivist. The importance of IS constructivist research is briefly explained. This is followed with a recapitul