BACKGROUND: Polymorphisms affecting Toll-like receptor (TLR) structure appear to be rare, as would be expected due to their essential coordinator role in innate immunity. Here, we assess variation in TLR4 expression, rather than structure, as a mechanism to diversify innate immune responses. METHODOLOGY/PRINCIPAL FINDINGS: We sequenced the TLR4 promoter (4,3 kb) in Swedish blood donors. Since TLR4

Advanced driving assistance systems that offer support by operating for example longitudinal control will have an effect on the transport system. Previous studies have also shown that drivers may be slower to respond in hazardous situations with systems like adaptive cruise control (ACC) engaged, if the system suddenly fails. Little understanding has, so far, emerged to explain why. In this thesis

Triple-negative breast cancer (TNB) has poor prognosis and moreover patients with TNB do not benefit from established targeted drugs with endocrine therapy or trastuzumab. The aim of the study was to analyze the prevalence of candidate biomarkers in tumors from patients with TNB. Tissue microarrays were prepared from primary tumors from premenopausal breast cancer patients (500/564) randomized to

Abstract not available.

In maintenance treatment for opiate addiction, buprenorphine can be administered less frequently than daily due to its long half-life.

Thrainsdottir S, Malik RA, Rosén I, Jakobsson F, Bakhtadze E, Petersson J, Sundkvist G, Dahlin LB. Sural nerve biopsy may predict future nerve dysfunction. Acta Neurol Scand: DOI: 10.1111/j.1600-0404.2008.01118.x. (c) 2008 The Authors Journal compilation (c) 2008 Blackwell Munksgaard.Objective - Sural nerve pathology in peripheral neuropathy shows correlation with clinical findings and neurophysio

T cells have been attributed an important role in modulating repair responses following vascular injury. The aim of this study was to investigate the role of different T cell subsets in this context.

PURPOSE: To identify changes in gene expression in the airways among welders, with and without lower airway symptoms, working in black steel. METHODS: Included were 25 male, non-smoking welders. Each welder was sampled twice; before exposure (after vacation), and after 1 month of exposure. From the welders (14 symptomatic, of whom 7 had asthma-like symptoms), RNA from induced sputum was obtained f

The aim of this article is to give a tentative illustration of how a creative, postpolitical citizen is imagined and encouraged to unfold within the frame of a city renewal project. As a starting point, the article outlines an exploratory framework structured through the analytical concept of postpolis. Postpolis is a term that offers an illustration of the distinguishing qualities of contemporary

Tourism is today the biggest industry in the world, and tour operators are a central link in the tourism supply chain. As a consequence of their key position, tour operators have the potential to influence both the primary producers of tourist services and the tourists. Increased awareness of the media and general public will create pressures on the tour operators - first to work towards incorpora