Background: This study investigates a broad spectrum of psychiatric disorders, substance use disorders, gambling, and internet gaming disorders in Swedish 18-year-old boys and girls with the aim of estimating the prevalence of disorders and comorbidity. Methods: We used a two-phase design with screening to detect candidates for clinical interviews. Screening included 949 adolescents (55.6% girls),

This thesis applied magnetic resonance imaging (MRI) to investigate to what extent very preterm birth due to early onset fetal growth restriction (FGR) impacts the cardiovascular system and kidneys in adolescence. The thesis further investigated whether FGR exacerbates the organ-specific effects of very preterm birth.Study I validated a widely available non-contrast enhanced MRI method for quantif

Optical microscopy has revolutionized the way we understand our world and has become a crucial tool in a range of disciplines such as biology, physics, chemistry, and material sciences. The development of new microscopy techniques has been capital to its success and wide applicability. A prominent example is the recent development of methods that allow imaging in three dimensions. This has been a

Introduction: Clinical Quality Registries (CQRs) were initiated in order to compare clinical outcomes between hospitals or regions within a country. To get an overview of these CQRs worldwide the aim of this study was to identify these CQRs for gynecological oncology and to summarize their characteristics, processes and QI's and to establish whether it is feasible to make an international comparis

Background and Objective: The recent multi-country outbreak of human monkeypox (HMPX) in non-endemic regions poses an emerging public health concern. University students in health schools/faculties represent a core knowledgeable group that can be helpful to study from a public health point of view. As future healthcare workers, assessment of their knowledge and attitude towards emerging zoonotic v

We revisit our rope model for string fragmentation that has been shown to give a reasonable description of strangeness and baryon enhancement in high-multiplicity pp events at the LHC. A key feature of the model is that the enhancement is driven by the increased string tension due to strings overlapping in dense systems. By introducing an improved space–time picture for the overlap between fragmen

COVID-19 vaccine hesitancy poses a threat to the success of vaccination programmes currently being implemented. Concerns regarding vaccine effectiveness and vaccine-related adverse events are potential barriers to vaccination; however, it remains unclear whether tailored messaging and vaccination programmes can influence uptake. Understanding the preferences of key groups, including students, coul

Hydrogen release during pyrolysis of woody biomass is studied considering anisotropicity and inhomogeneity of wood structure. A new anisotropic shrinkage model is proposed based on the decomposition of main wood constituents, i.e., cellulose, hemicellulose, and lignin. The new shrinkage model can predict the temporal evolution of the wood structure, and the differences between axial and radial shr

Despite its role in ensuring the ubiquity of fossil fuels in modern society, the petrochemical sector has long flown under the public radar in energy and climate debates. However, faced with increasing pressures from its involvement in driving multiple and intersecting ecological crises, firms in the petrochemical industry are seeking to make sustainability a core part of their public image. Altho

Malaria är en sjukdom som orsakas av parasiter av plasmodium släktet och överförs mellan människor av myggor. Då myggan biter en malariasmittad människa och förtär dess blod så innehåller detta blod parasiter som i senare sprids ifrån myggans mage och vidare till dess salivkörtlar. När myggan vid ett senare tillfälle biter en frisk människa, överförs parasiten från salivkörtlarna till människans bMalaria is a massive global health crisis that is most prevalent in tropical regions of Africa, Asia, and Latin America. The World Health Organization (WHO) estimated in 2013 that 3.3 billion people were at risk of being infected by the disease, resulting in around 200 million cases with more than 500 000 of these cases leading to lethal outcome. Africa was by far the most affected by the disease

Aims: Paediatric brain tumours are rare, and establishing a precise diagnosis can be challenging. Analysis of DNA methylation profiles has been shown to be a reliable method to classify central nervous system (CNS) tumours with high accuracy. We aimed to prospectively analyse CNS tumours diagnosed in Sweden, to assess the clinical impact of adding DNA methylation-based classification to standard p

Importance: Patients who survive severe intracerebral hemorrhage (ICH) and intraventricular hemorrhage (IVH) typically have poor functional outcome in the short term and understanding of future recovery is limited. Objective: To describe 1-year recovery trajectories among ICH and IVH survivors with initial severe disability and assess the association of hospital events with long-term recovery. Des

There is no inherent meaning in endurance experiences. The experience is accorded meaning in dialogue with the world around us. In this critical exploration of endurance running, endurance runners’ accounts of their consumption of endurance are analysed to reveal what they indicate about contemporary society. The findings question the idea - prevalent in consumer research - that endurance experien

ATP7B is a human copper-transporting P1B-type ATPase that is involved in copper homeostasis and resistance to platinum drugs in cancer cells. ATP7B consists of a copper-transporting core and a regulatory N-terminal tail that contains six metal-binding domains (MBD1-6) connected by linker regions. The MBDs can bind copper, which changes the dynamics of the regulatory domain and activates the protei