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Delirium is a serious and common condition in the intensive care unit (ICU), which affects 30-50 % of the patients and is associated with increased mortality and morbidity in the context of long-term outcomes. No evidence-based treatment for delirium exists, and currently, delirium is mainly treated pharmacologically with haloperidol, a typical antipsychotic agent. The “Agents Intervening against

It is vital to consider acoustic scattering when using geometrical acoustic simulation techniques, such as ray tracing. However, there are few methods for modelling scattering, and most rely on strong assumptions of uniformity on the distribution of scattered energy. In this paper, a model for directional scattering in ray tracers is presented. The model is based on an idealized model of a 1D scat

Room acoustic simulations are an important tool, both for design of spaces with satisfactory acoustics and for use in virtual reality experiences. Auralization of acoustic simulations are becoming more and more important in the context of Virtual and Augmented reality (VR and AR respectively), as the technology is used more and more in healthcare, culture and research. In this work, ray tracing si

Traditionally, psychophysical data is modelled by fitting individual curves to each participant’s data and then by statistical analysis of the extracted parameters. A now viable alternative to this traditional two-stage approach is Bayesian hierarchical modelling (BHM). BHM allows for modelling all of the data and all of the parameters in one-step rather than two. Here, BHM is used to analyse the

The emergence of complementary and community currencies (CCCs) at a global and local scale manifests the normative innovation that characterizes these initiatives. Based on three case studies of CCCs in the Basque Country (the Ekhi, the Eusko and the Txantxi) the present paper explores the normative order of the CCCs and their processes of institutionalization through tactics of legal convergence.

Although we have learned much about how the brain fuels its functions over the last decades, there remains much still to discover in an organ that is so complex. This article lays out major gaps in our knowledge of interrelationships between brain metabolism and brain function, including biochemical, cellular, and subcellular aspects of functional metabolism and its imaging in adult brain, as well

I projektet studeras det digitala verktyget Flow och dess inverkan på personalens arbetsmiljö samt på kostnadseffektiviteten i svensk primärvårdskontext. Flow ger patienten möjlighet till digital kontakt och kommunikation med vårdcentralen samt möjlighet till digital kommunikation mellan olika personalgrupper inom vårdcentralen. Implementeringen av Flow har studerats på tre vårdcentraler: A, B och

In this contribution, we propose a model of Quaternary seismicity in the Outer Western Carpathians. The model presents results of analysis of fractured clasts performed in 268 exposures of Quaternary fluvial gravels within the ca. 5,000 km2 large segment of the Outer Western Carpathians comprising: Outer Carpathian nappes, the innermost part of the Carpathian Foredeep, and two intramontane basins

INTRODUCTION: The pace of innovation has accelerated in virtually every area of tau research in just the past few years. METHODS: In February 2022, leading international tau experts convened to share selected highlights of this work during Tau 2022, the second international tau conference co-organized and co-sponsored by the Alzheimer's Association, CurePSP, and the Rainwater Charitable Foundation

We introduce a new method to calculate dark matter halo density profiles from simulations. Each particle is ‘smeared’ over its orbit to obtain a dynamical profile that is averaged over a dynamical time, in contrast to the traditional approach of binning particles based on their instantaneous positions. The dynamical and binned profiles are in good agreement, with the dynamical approach showing a s

Importance: Hypochondriasis, also known as health anxiety disorder, is a prevalent, yet underdiagnosed psychiatric disorder characterized by persistent preoccupation about having serious and progressive physical disorders. The risk of mortality among individuals with hypochondriasis is unknown. Objective: To investigate all-cause and cause-specific mortality among a large cohort of individuals wit

The main protease Mpro, nsp5, of SARS-CoV-2 (SCoV2) is one of its most attractive drug targets. Here, we report primary screening data using nuclear magnetic resonance spectroscopy (NMR) of four different libraries and detailed follow-up synthesis on the promising uracil-containing fragment Z604 derived from these libraries. Z604 shows time-dependent binding. Its inhibitory effect is sensitive to

We derive the order p 8 Lagrangian of odd intrinsic parity for mesonic chiral perturbation theory, and provide the resulting operator basis in the supplementary material. Neglecting the non-zero singlet trace, we find 999 operators for a general number of quark flavours Nf , 705 for Nf = 3 and 92 for Nf = 2. Our numbers agree with those obtained through the Hilbert series approach in the literatur

The Sun’s energy is effectively limitless. While resources such as coal or gas are finite, if you are able to capture and use solar power it doesn’t prevent anyone else from also using as much sunshine as they need.Except that isn’t quite the full story. Beyond a certain size, solar farms become large enough to affect the weather around them and ultimately the climate as a whole. In our new resear

Background: Thymic stromal lymphopoietin (TSLP) is released from the airway epithelium in response to various environmental triggers, inducing a type-2 inflammatory response, and is associated with airway inflammation, airway hyperresponsiveness (AHR), and exacerbations. TSLP may also induce AHR via a direct effect on airway smooth muscle and mast cells, independently of type-2 inflammation, altho