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Photoreceptor cells finely adjust their sensitivity and electrical response according to changes in light stimuli as a direct consequence of the feedback and regulation mechanisms in the phototransduction cascade. In this study, we employed a systems biology approach to develop a dynamic model of vertebrate rod phototransduction that accounts for the details of the underlying biochemistry. Followi
Popular Abstract in Swedish Inledning I detta avhandlingsarbete studeras Mycoplasma pneumoniae (MP) och influensa virus ur olika perspektiv. Dessa två smittämnen orsakar båda årliga utbrott med luftvägsinfektioner som ibland blir omfattande epidemier. I båda fallen kan symptomen variera från lätta förkylningsbesvär till mycket svåra, ibland livshotande lunginflammationer. Infektion med MycoplasmaDiagnostic tests based on nucleic acid amplification have become available for Mycoplasma pneumoniae (MP) and influenza viruses. Here, an MP PCR test detected 100% of infections during the first three symptomatic weeks, whereas classical serology detected 21% week 1, 56% week 2, and 100% week 3. Positive PCR results were uncommon in healthy individuals. Levels of MP DNA were significantly higher i
Background: During their evolution in the Late Cretaceous, mosasauroids attained a worldwide distribution, accompanied by a marked increase in body size and open ocean adaptations. This transition from land-dwellers to highly marine-adapted forms is readily apparent not only at the gross anatomic level but also in their inner bone architecture, which underwent profound modifications. Methodology/P
Objective:To compare the diagnostic accuracy of CSF biomarkers and amyloid PET for diagnosing early-stage Alzheimer disease (AD).Methods:From the prospective, longitudinal BioFINDER study, we included 122 healthy elderly and 34 patients with mild cognitive impairment who developed AD dementia within 3 years (MCI-AD). -Amyloid (A) deposition in 9 brain regions was examined with [F-18]-flutemetamol
Learning from incidents is considered a very important source for learning and improving safety in the process industries. However, the effectiveness of learning from reported incidents can often be ques-tioned. Therefore, there is a need to be able to evaluate the effectiveness of learning from incidents, and for that purpose we need methods and tools. In this paper, a method is described for eva
Background: Biomass fuel smoke exposure contributes to respiratory infections in childhood, but its association with asthma has not been established. We studied the relationship of biomass fuel use with asthma symptoms and lung function in Nigerian children. Methods: A cross-sectional study was performed in 299 village children aged 5-11 years in North Central Nigeria. Data were collected regardin
The Macrocyclic Lactone and Lactide derivative (ML) group of fragrance ingredients was critically evaluated for safety following a complete literature search. For high end users, calculated maximum dermal exposures vary from 0.47% to 11.15%; systemic exposures vary from 0.0008 to 0.25 mg/kg/day. The MLs had low acute toxicity and no significant toxicity in repeat dose oral ordermal toxicity studie
Despite more than 25 years of research, the molecular targets of quinoline-3-carboxamides have been elusive although these compounds are currently in Phase II and III development for treatment of autoimmune/inflammatory diseases in humans. Using photoaffinity cross-linking of a radioactively labelled quinoline-3-carboxamide compound, we could determine a direct association between human S100A9 and
Recension av Anders Frankson (red.); Avgörande ögonblick under andra världskriget.
Diffusional transport across lipid membranes can be highly complex and include several parallel transport processes. It is typical for the responding lipid membrane that small changes in the membrane environment can lead to major changes in membrane structure. In a multilayer membrane, the response can lie in heterogeneous swelling and phase transformations. The changes in membrane structure profo
In my article, I am discussing two main concepts of special interest when studying gender and religion in modern Western society, namely the theory of a feminisation of Christianity in the 19th century and the concept of a reconfessionalisation of European society. The previous concept is developed on the basis of studies on liberal-bourgeois milieus, where a belief in science and social progress
Physiological evidence indicates that high-protein diets reduce caloric intake and increase thermogenic response, which may prevent weight gain and regain after weight loss. Clinical trials have shown such effects, whereas observational cohort studies suggest an association between greater protein intake and weight gain. In both types of studies the results are based on average weight changes, and
Objective To derive simple and clinically useful ultrasound-based rules for discriminating between benign and malignant adnexal masses. Methods In a multicenter study involving nine centers consecutive patients with persistent adnexal tumors underwent transvaginal gray-scale and Doppler ultrasound examination using a standardized examination technique and standardized terms and definitions. Inform
A control treatment in acupuncture research must be credible, regardless if the needting is performed by one or by several therapists. Objective: To investigate if individuals could identify whether neediing had been given with an acupuncture needle or a sham needle and if the therapist influenced this ability. Design: Eighty individuals were randomized to one single needling given by one of four
Polymorphisms near the IL28B gene, which code for interferon (IFN)-lambda 3, predict response to pegylated interferon-alpha (PEG-IFN) and ribavirin treatment in hepatitis C virus (HCV) genotype 1 infected patients. Follow-up studies of the effect of IL28B gene in HCV non-genotype 1 infected patients have almost always used predominantly HCV genotype 2-infected or mixed genotype 2/3-infected cohort
