Medieval round churches are often seen as riddles in need of special explanation. Deviant architecture has been explained by three major theories – fortification, multi-functionality and symbolic copying. However, I claim that the round churches were normal except for their elite context and extraordinary plan. I then argue, that the elite consciously choose a “conspicuous architecture”, to use a

The mean effective gain (MEG) for Rice distributed signals impinging at the terminal receiver antenna is presented. Numerical results are presented for three different angular probability distributions of impinging waves. Finally, it is shown that contrary to the Rayleigh channels in Ricean channels there is no inclination angle at which the MEG of the half-wave dipole antenna remains constant reg

This paper presents an investigation of rational agents that have limited computational resources and that can interact with their environments. We analyse how such agents can combine deductive reasoning using domain knowledge and inductive learning from past experiences, while remaining time-aware in a manner appropriate for beings situated in a dynamic universe. In particular, we consider how th

Abstract in Danish Artiklen argumenterer for, at vi alle fødes som mennesker, og at vi alle dør som mennesker; starttidspunktet er os givet; sluttidspunktet kender vi ikke, og det er i princippet uden ’aldersberegning’. Vores livshistorie er med til at skabe, forme og beskrive os; gennem hele livet og også ind i døden. Alder kan forstås og beskrives på mange måder, hvor vi ofte kategoriserer og it

Context: The previously reported absence of 65-kDa glutamate decarboxylase antibody (GAD65Ab)-specific antiidiotypic antibodies (anti-Id) in type 1 diabetes (T1D) patients at clinical onset could be due to an inability to mount an antibody response to GAD65Ab or a longitudinal decline in anti-Id levels. Objective and Design: We investigated anti-Id levels in longitudinal samples obtained from T1D

ObjectiveFibroproliferative diseases are common causes of morbidity and mortality. Interleukin-15 (IL-15) is a pleiotropic cytokine with multiple effects on cells of the immune system. Although IL-15 is also expressed in mesenchymal cells, its effects on the development of fibrosis are unknown. We have previously described an association between serum IL-15 levels and the extent of pulmonary fibro

Patient-reported outcomes (PROs), such as symptoms and perceived health status, are essential in chronic obstructive pulmonary disease (COPD) for determining disease severity, impact on daily life, effect of treatment and recovery from exacerbations. This field has evolved rapidly and there are a plethora of instruments assessing different PROs. Here, we aim to provide an understanding of the conc

Several in vitro studies have emphasized the importance of toll-like receptor/myeloid differentiation factor 88 (MyD88) signaling in the inflammatory response to Streptococcus pyogenes. Since the extent of inflammation has been implicated in the severity of streptococcal diseases, we have examined here the role of toll-like receptor/MyD88 signaling in the pathophysiology of experimental S. pyogene

Triple-negative breast cancer (TNBC) is associated with poor prognosis and no targeted treatments are available for TNBC. Drugs inhibiting tyrosine kinases, such as vascular endothelial growth factor receptor 2 (VEGFR2) and KIT, have shown some promising results for patients with TNBC. The aim of the study was to investigate whether gains and/or amplifications of VEGFR2 and KIT, located at 4q12, o

The ATP-dependent insertion of Mg(2+) into protoporphyrin IX is the first committed step in the chlorophyll biosynthetic pathway. The reaction is catalyzed by magnesium chelatase, which consists of three gene products: BchI, BchD, and BchH. The BchI and BchD subunits belong to the family of AAA+ proteins (ATPases associated with various cellular activities) and form a two-ring complex with six Bch

This 12-month prospective controlled intervention evaluated the effect of a general school based physical activity program on muscle strength, physical performance and body composition in prepubertal girls. Fifty-three girls aged 7-9 years involved in a school based exercise program [40 min/day of general physical activity per school day (200 min/week)] were compared with 50 age-matched girls who

Abstract is not available