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Cigarette smoke (CS), a major driver of lung cancer (LC), promotes epithelial-mesenchymal transition (EMT) and stemness resulting in metastasis, therapy resistance, and recurrence, but the precise mechanism is elusive. Building on our earlier identification of Runt related transcription factor-2 (RUNX2) and Galectin-3 (Gal-3) as mediators of CS-induced EMT, in this study, we aimed to identify a po

Background: Neoadjuvant therapy is protective of postoperative pancreatic fistula in pancreatoduodenectomy. However, the effect of neoadjuvant therapy after left pancreatectomy remains unclear. The aim of this international multicenter study was to evaluate the impact of neoadjuvant therapy on short term outcomes after left pancreatectomy for pancreatic ductal adenocarcinoma. Methods: Patients und

We study a class of radially symmetric Coulomb gas ensembles at inverse temperature β=2, for which the droplet consists of a number of concentric annuli, having at least one bounded “gap” G, i.e., a connected component of the complement of the droplet, which disconnects the droplet. Let n be the total number of particles. Among other things, we deduce fine asymptotics as n→∞ for the edge density a

This study investigates the influence of osteoarthritis (OA) disease severity on the bio-composition of the osteochondral junction at the human tibial plateau using Raman microspectroscopy. We specifically aim to analyze the spatial composition of mineralized osteochondral tissues, i.e., calcified cartilage (CC) and subchondral bone plate (SBP) from unfixed, hydrated specimens. We hypothesize that

Objective: Mitochondria are involved in cellular metabolism, energy production, calcium homeostasis, and the synthesis of sterols and bile acids (BAs). Emerging evidence suggests that mitochondrial dynamics including biogenesis, fusion, fission, and mitophagy critically influence cardiometabolic diseases, yet their role in atherogenesis remain poorly understood. Mitochondrial fusion ensures metabo

Background: Paleolithic Diet Fraction (PDF) and Paleolithic Diet Score (PDS) are both measures of how closely a food intake conforms to a Paleolithic dietary pattern. PDF is calculated directly from an individual’s absolute food intake and PDS is an aggregated score based on an individual’s food intake relative to a population. Both are inversely associated with all-cause and cause-specific mortal

Background/Aim: The TGF-β pathway can influence breast cancer progression and therapy efficacy, exhibiting both pro- and anti-tumoral effects. This study examined the impact of active TGF-β signaling on recurrence and radiotherapy (RT) benefit in early-stage breast cancer, using nuclear phosphorylated Smad2 (pSMAD2) as a marker for pathway activation. Methods: Tissue-microarrays from 1178 stage I-

This study’s aim is to shed some light on the topic of garden archaeology in Sweden. This is done by introducing the reader to the topic as a whole, with its methods and its history not only in Sweden. Garden Archaeology is a relatively new focus within archaeology and therefor in need of an introduction. The main focus is the concept of ideal versus reality in higher status gardens from the 1

This thesis examines living conditions in Malmö during the 19th-century through the prevalence of stress related changes in an osteological material, in combination with historical archives. With a structural violence framework, the research aims to study health, nutrition, trauma and workload in individuals from the lowest socioeconomic group, soldiers and prisoners. An osteological analysis has

This thesis approaches the cryptoporticus of private roman architecture in the context of the rural villa and urban domus, with the explicit purpose of examining how the functions and roles of this multifaceted structure differs in these settings. In order to accomplish this goal, the thesis employs a comparative methodology where specific attributes of eleven buildings with a cryptoporticus are p

This essay examines how the parish churches of Nättraby and Hjortsberga in central Blekinge changed during the latter part of the 17th century, as well as how the churches’ material properties as standing history were handled by the parishioners. Blekinge became part of Sweden in 1658 and the Swedish crown founded a large naval base in the churches’ vicinity soon after. Both churches went through

This paper attempts to explore the relationship between artefacts, landscape and museums. To do so it aims to identify a method that can be applied to both the museological landscape as well as archeological artifacts. With that information, the aim of this paper is to analyse how norm-creating behavior affects museum visitors' view of the artefacts on display. This paper draws from both well