There are emerging data to support a role for genetic and immune-related factors in the pathogenesis of lymphoplasmacytic lymphoma/Waldenstrom's macroglobulinemia. In this article, we review our recently published, large, population-based studies using data from Sweden and from United States veterans and propose mechanisms and pathways underlying our observations. We also discuss future directions

Purpose – The rate of turnover of hospital managers has been high in Sweden. Hospitals are regarded to be difficult to manage, which is connected with different discourses and action logics such as politics, medicine, care and management creating complex conditions for hospital management. The purpose of this paper is to analyse hospital managers' management conditions in conjunction with hospital

Lifestyle behaviors and genetic variation have clear and distinguishable effects on obesity risk; however, the pattern of disease occurrence within and between populations that differ in their genetic and environmental underpinnings suggests obesity is caused in part by the interaction between adverse lifestyle behaviors and the genetic risk profile of an individual. This thesis aims to investigat

The aim of this paper is to find a multiple window estimator that is mean square error optimal for cepstrum estimation. The estimator is compared with some known multiple window methods as well as with the parametric AR-estimator. The results show that the new estimator has high performance, especially for data with large spectral dynamics, and that it is also robust against parameter choices. Sim

NADPH is a key reductant carrier that maintains internal redox and antioxidant status, and that links biosynthetic, catabolic and signalling pathways. Plants have a mitochondrial external NADPH oxidation pathway, which depends on Ca2+ and pH in vitro, but concentrations of Ca2+ needed are not known. We have determined the K0.5(Ca2+) of the external NADPH dehydrogenase from Solanum tuberosum mitoch

Both ammonia-oxidizing archaea (AOA) and ammonia-oxidizing bacteria (AOB) play an important role in nitrification in terrestrial environments. Most often AOA outnumber AOB, but the relative contribution of AOA and AOB to nitrification rates remains unclear. The aim of this experiment was to test the hypotheses that high nitrogen availability would favor AOB and result in high gross nitrification r

The glaciotectonic architecture and structural evolution of a fine-grained end moraine formed by the 1890 glacier surge of Bruarjokull is described from four excavated cross-sections. The end moraine ridge is a morphological expression of a marginal sedimentary wedge formed during the last days of the surge. The actual end-moraine ridge was formed on the last day of the 1890 surge when the glacier

Strömsrum in SE Sweden is one of the most important areas for threatened insects in northern Europe. This is a review of the red-listed and formerly red-listed species of wood-living beetles collected at Strömsrum with notes of their habitats. In an area of a few hundred hectares over 1000 old hollow oaks and almost as many hollow trees of other deciduous trees occur. From the current red list (Gä

An imaging technique capable of measuring the extinction coefficient in 3D is presented and demonstrated on various scattering media. The approach is able to suppress unwanted effects due to both multiple scattering and light extinction, which, in turbid situations, seriously hampers the performance of conventional imaging techniques. The main concept consists in illuminating the sample of interes

In this paper a controller reduction method which preserves closed loop stability is described. A Lyapunov inequality based sufficient condition is proposed in the search of the reduced controller. The reduced controller leads to a stable closed loop system with guaranteed approximation quality. Furthermore, the proposed problem can be formulated as a matrix approximation problem which can be solv

Objectives: Uncomplicated acute type B aortic dissection (AD) treated conservatively has a 10% 30-day mortality and up to 25% need intervention within 4 years. In complicated AD, stent grafts have been encouraging. The aim of the present prospective randomised trial was to compare best medical treatment (BMT) with BMT and Gore TAG stent graft in patients with uncomplicated AD. The primary endpoint

Ad4BP/SF-1 (Adrenal4 Binding Protein/Steroidogenic Factor-1 (NR5A1)) is a factor important for animal reproduction and endocrine regulation, and its expression is tightly regulated in the gonad, adrenal gland, ventromedial hypothalamic nucleus (VMH), and pituitary gonadotrope. Despite its functional significance in the pituitary, the mechanisms underlying pituitary-specific expression of the gene

Haem (protohaem IX) analogues are toxic compounds and have been considered for use as antibacterial agents, but the primary mechanism behind their toxicity has not been demonstrated. Using the haem protein catalase in the Gram-positive bacterium Enterococcus faecalis as an experimental system, we show that a variety of haem analogues can be taken up by bacterial cells and incorporated into haem-de

A comparison between throttled and unthrottled spark ignition combustion with residual enhanced HCCI combustion is made. Early intake valve closing and late intake valve closing valve strategies for unthrottled spark ignition combustion are evaluated and compared. Approximately 3-6 percent relative improvement in net indicated efficiency is seen when comparing unthrottled spark ignition combustion

A search is reported for a neutral Higgs boson in the decay channel H -> Z gamma, Z -> l(+)l(-) (l = e, mu), using 4.5 fb(-1) of pp collisions at root s = 7 TeV and 20.3 fb(-1) of pp collisions at root s = 8 TeV, recorded by the ATLAS detector at the CERN Large Hadron Collider. The observed distribution of the invariant mass of the three final-state particles, m(ll gamma), is consistent with the S

Monte Carlo simulations and coarse-grained modelling have been used to analyze Histatin 5, which is an unstructured short cationic salivary peptide known to have anti-candidical properties. The calculated scattering functions have been compared with intensity curves and the distance distribution function P(r) obtained from SAXS, at both high and low salt concentrations. The aim is to achieve a mol