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We demonstrate, using analytic models, simulations and experiments, that efficient generation of high-order harmonics is possible across a large range of parameters, if the density and medium length follow a hyperbolic equation.
This paper presents an injection-locked frequency tripler for 28-GHz direct-conversion transceivers, which takes a differential input and outputs a quadrature signal. A feedback system is added to ensure that lock occurs and to keep the quadrature error below 1° across operating frequencies and process corners. Simulations show that the tripler can cover the entire 24-30 GHz band across all corner
Flatness of the loss curve around a model at hand has been shown to empirically correlate with its generalization ability. Optimizing for flatness has been proposed as early as 1994 by Hochreiter and Schmidthuber, and was followed by more recent successful sharpness-aware optimization techniques. Their widespread adoption in practice, though, is dubious because of the lack of theoretically grounde
Introduction: The European corn borer (ECB), Ostrinia nubilalis (Hübner) (Lepidoptera: Crambidae), is a major pest insect in maize. New cultivars and climate change have allowed range expansion of the crop northwards in Europe, and a similar range expansion of associated pests has been predicted. ECB exists as two distinct pheromone strains using different blends of (E)-11-tetradecenyl acetate and
Fibromyalgia is a common chronic pain condition. Rates of contact allergy in individuals with fibromyalgia have not been widely studied. Systemic contact allergy can present with muscle and joint pain and general malaise. The aim of this study is to investigate contact allergy rates in individuals with fibromyalgia to the sensitizers in an extended dental series and compare with control groups. Co
In the fields of behavioural and psychological research, pupil size and skin conductance are two variables that provide useful information about a participant’s state of mind at a given moment. Both variables are involuntary indicators of psychophysiological responses such as alertness, arousal, or focus. Pupil size is commonly measured with a video-based eye tracker, and skin conductance is measu
Background: Tonsillar cancer is caused by high-risk human papillomavirus (HPV), tobacco smoking, and alcohol abuse. Aspects of the patient’s immune response to this disease have arisen as prognostic factors and treatment targets, reflecting differences in the type and protein expression profile of immune cells. Because tonsillar cancers are heterogenous lesions such data need to be spatially resol
The European Spallation Source (ESS) is an under-construction material science research facility in Lund, Sweden, and will upon completion host the most powerful superconducting linear accelerator (linac) in the world. The ESS linac is powered by klystron modulators required to deliver long high-power pulses (pulse amplitude 115 kV/100 A, pulse length 3.5 ms, pulse repetition rate 14 Hz) of very h
This article discusses the rationale for inclusion of flow cytometry (FCM) in the diagnostic investigation and evaluation of cytopenias of uncertain origin and suspected myelodysplastic syndromes (MDS) by the European LeukemiaNet international MDS Flow Working Group (ELN iMDS Flow WG). The WHO 2016 classification recognizes that FCM contributes to the diagnosis of MDS and may be useful for prognos
Radionuclide therapy, also called molecular radiotherapy (MRT), has come of age, with several novel radiopharmaceuticals being approved for clinical use or under development in the last decade. External beam radiotherapy (EBRT) is a well-established treatment modality, with about half of all oncologic patients expected to receive at least one external radiation treatment over their disease course.
Mycobacteria have an atypical thick and waxy cell wall. One of the major building blocks of such mycomembrane is trehalose monomycolate (TMM). TMM is a mycolic acid ester of trehalose that possesses long acyl chains with up to 90 carbon atoms. TMM represents an essential component of mycobacteria and is synthesized in the cytoplasm, and then flipped over the plasma membrane by a specific transport
Background and purpose — Concerns exist regarding the generalizability of results from randomized controlled trials (RCTs) evaluating arthroscopic partial meniscectomy (APM) to treat degenerative meniscus tears. It has been suggested that study populations are not representative of subjects selected for surgery in daily clinical practice. There-fore, we aimed to compare patients included in trials
Gene amplification is a crucial process in cancer development, leading to the overexpression of oncogenes. It manifests cytogenetically as extrachromosomal double minutes (dmin), homogeneously staining regions (hsr), or ring chromosomes (r). This study investigates the prevalence and distribution of these amplification markers in a survey of 80 131 neoplasms spanning hematologic disorders, and ben
Aims Gene fusions assays are key for personalised treatments of advanced human cancers. Their implementation on cytological material requires a preliminary validation that may make use of cell line slides mimicking cytological samples. In this international multi-institutional study, gene fusion reference standards were developed and validated. Methods Cell lines harbouring EML4(13)–ALK(20) and SL
Background: Depression and anxiety often reduce people’s ability to cope with everyday occupations. There is a lack of knowledge about such problems in people of working age with depression and anxiety. Aim: To describe which problems people with depression or anxiety disorders experience when performing everyday occupations and which occupations are affected. Materials and methods: Data based on
