(Matrix presented) A combinatorial scaffolding procedure for the synthesis and spatial arrangement of tripartite structures was developed.

1-(Benzothiazol-2-yl)-1-(4-chlorophenyl)ethanol (1) was identified as a positive allosteric modulator (PAM) of the CaSR in a functional cell-based assay. This compound belongs to a class of compounds that is structurally distinct from other known positive allosteric modulators, for example, the phenylalkylamines cinacalcet, a modified analog (13) potently suppressed parathyroid hormone (PTH) relea

Synthesis of substituted 4-benzyloxypyridinium salts by the addition of Grignard reagents to pyridine N-oxides provides an efficient route for obtaining substituted 4-pyridones or 4-aminopyridinium salts.

The possibilities of using combined capillary gas chromatography mass spectrometry for highly sensitive and selective determinations of enantiomeric alanines of bacterial origin have been evaluated. The alanines were separated as their diastereoisomeric N‐heptafluorobutyryl‐2‐butyl ester derivatives on a 25 m fused silica capillary column coated with SE‐54 as stationary phase. The mass spectra of

Generally, simplified manual protocols can serve as a cost-effective alternative to sophisticated automation solutions. We have developed, validated and implemented a quick, inexpensive and efficient one-tube direct lysis DNA extraction protocol for the majority of our crime scene samples. The method includes one pipetting step, the addition of a lysis buffer based on Chelex beads, Proteinase K an

The growing energy demand and the impact of polluting gases lead to the necessity of alternative energy sources and conversion energy devices. Fuel cells (FCs) appears as a suitable solution for facing the mentioned issues. Predicting the behavior of a polymer electrolyte fuel cell (PEFC) under different conditions represents a proper initial step to solve the several issues, e.g., aging water bal

Biogenic volatile organic compounds (BVOCs) can be released from soils to the atmosphere through microbial decomposition of plant residues or soil organic carbon, root emission, evaporation of litter-stored BVOCs, and other physical processes. Soils can also act as a sink of BVOCs through biotic and abiotic uptake. Currently, the source and sink capabilities of soils have not been explicitly accou

A field study on current structure and circulation characteristics in Lake Vendyurskoe, a small, shallow, icecovered lake in Karelia, Russia, is presented. The current velocity magnitudes were generally found to be small. The most pronounced currents had an oscillating character, with velocity amplitudes on the order of millimeters per second. The oscillation period, obtained from spectral density

The overall circulation pattern in spring is rather specific as density-induced currents may be of significance. The density-driven circulation perpendicular to the shore can be described as consisting of two circulation cells, with a zone of convergence, referred to as thermal bar, in between. The thermal bar, which coincides with the 4°C isotherm (the temperature of maximum density), inhibits ho

Pierre Bourdieu has been an extraordinarily influential figure in the sociology of music. For over four decades, his concepts have helped to generate both empirical and theoretical interventions in the field of musical study. His impact on the sociology of music taste, in particular, has been profound, his ideas directly informing our understandings of how musical preferences reflect and reproduce

This talk reports on the compilation of the new London–Lund Corpus (LLC–2) –a corpus of contemporary spoken British English, collected 2014–2019. The sizeand design of LLC–2 are the same as that of the world’s first corpus of spokenlanguage, namely the London–Lund Corpus (LLC–1), with spoken data mainlyfrom the 1960s. In addition to the fact that we have a corpus of contemporary speech, the existe

Eva Sæther’s keynote is based on research on how the Art and Music School in Malmö, through the implementation of El Sistema since 2013, navigates in the tension fields that emerge when music educators balance artistic and social expectations on their profession. Since the implementation of El Sistema the music school in Malmö has been able to include children from all backgrounds in the targeted