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Background: The occurrence of mosaicism in hemophilia A (HA) has been investigated in several studies using different detection methods.Objectives: To characterize and compare the ability of AmpliSeq/Ion Torrent sequencing and droplet digital polymerase chain reaction (ddPCR) for mosaic detection in HA.Methods: Ion Torrent sequencing and ddPCR were used to analyze 20 healthy males and 16 mothers o
The number of policies that address the various life cycle environmental impacts of products are increasing, especially in Europe. With the rise of the Circular Economy (CE) concept, the traditional product policies have been supported by new ones that pursue new policy objectives such as increasing product lifetimes and encourage more repairs. In this contribution we discuss principles for improv
Integration of disaster risk reduction (DRR) and climate change adaptation (CCA) is widely recognized as a solution for reducing the risk and impacts of disasters. However, successful integration seems elusive, and the two goals continue to function in isolation and in parallel. This article provides empirical insights into the perceived effects of separating government institutions for DRR and CC
Flood risk is a great global concern that is not only affecting developing countries, but threatens to undermine sustainable development also in the most affluent advanced liberal democracies. While political inertia is delaying much needed global change, efforts to reduce risk and adapt to a changing climate are growing on more local levels. However, floods tend not to be bounded by geopolitical,
In this article we elaborate on the process of institutionalization in the Higher Education performance evaluation ecosystem. We argue, we can observe a shift in how research evaluation functions, namely, from the contribution to knowledge to that of the societal influence of research. Such an axiological shift in evaluation goes to the very core of academic scholarship, as the commoditised neolib
In addition to their fundamental role in clearance, the kidneys release select molecules into the circulation, but whether any of these anabolic functions provides insight on kidney health is unknown. Using aptamer-based proteomics, we characterized arterial (A)-to-renal venous (V) gradients for >1,300 proteins in 22 individuals who underwent invasive sampling. Although most of the proteins that c
Traumatic brain injury (TBI) is a leading cause of death and disability. Progressive intracranial bleeding is common in TBI and worsens outcome. The multicentre, randomized placebo-controlled CRASH-3 study enrolling 12,737 patients showed that early, <3h, administration of tranexamic acid (TXA) decreased mortality in mild-moderate TBI patients. In accordance with large previous trials, thromboembo
Nanowires (NWs) are novel nanomaterials with applications in everything from medical implants to solar cells. With increasing number of applications, it is increasingly likely that organisms are exposed to these materials either intentionally or by accident. It is, therefore, important to study their interactions with biological systems and biomolecules. Upon exposure to biological fluids, nanostr
Objective: To examine whether C4d plasma levels correlate with treatment response and C4d kidney deposition in systemic lupus erythematosus (SLE) with lupus nephritis (LN). Methods: C4d plasma levels were analyzed by a unique assay specifically detecting C4d arising from complement activation and C4 plasma levels were quantified with competitive ELISA. SLE patients with LN (71) and active SLE pati
Agricultural intensification based on smallholders is among many economists viewed as a necessary developmental path to ensure food security and poverty reduction in sub-Saharan Africa. Increasingly, a one-sided focus on raising productivity in cereals has been questioned on environmental grounds, with the concept of sustainable agricultural intensification (SAI) emerging from the natural sciences
Objective Survival in epithelial ovarian cancer (EOC) remains poor. Most patients are diagnosed in late stages. Early diagnosis increases the chance of survival. We used the proximity extension assay from Olink Proteomics to search for new protein biomarkers with the potential to improve the diagnostic performance of CA125 and HE4 in patients with ovarian tumors. Material and methods Plasma sample
The seminal vesicle secretions of guinea pig and rabbit were analyzed for semen coagulum proteins. Using SDS-PAGE we discovered a previously not fully recognized semen coagulum protein, Svp5, in the guinea pig and a single predominant component, SVP200, in the rabbit. Potential genes of these proteins were identified in genome databases by their homology with human and murine genes. The structure
Background: Glenohumeral osteoarthritis can, in the most severe cases, require surgery with insertion of a shoulder arthroplasty. A design with a stem in the humeral bone canal is currently regarded as the standard treatment option in patients who have an intact rotator cuff function, but complications related to the stem including humeral fractures can have devastating consequences. By using a st
Background: To date, targeted temperature management (TTM) is the only neuroprotective intervention after resuscitation from cardiac arrest that is recommended by guidelines. The evidence on the effects of TTM is unclear. Methods/design: The Targeted Hypothermia Versus Targeted Normothermia After Out-of-hospital Cardiac Arrest (TTM2) trial is an international, multicentre, parallel group, investig
This book presents studies of ways in which people and organizations deal with the overflow of information, goods, or choices. The contributors explore two main themes. The first is the emergence of overflows: What is defined as overflow? Here the notion of framing as coined by Michel Callon has guided our approach. There is no overflow until some flow has been framed; framing means defining, and
För 300 år sedan avrättades en man och hans avlidna hustrus syster ifall det avslöjades att de hade haft sexuellt umgänge. Deras relation definierades som incestuös och benådningar var sällsynta. Incestförbuden omfattade då många fler relationskategorier än idag och fram till sent 1800-tal var de flesta incestuösa relationer frivilliga föreningar mellan två vuxna individer som saknade biologiska sThis study brings out the norms and culturally dependent values that formed the basis of the theoretical regulation and the practical handling of incest cases in Sweden 1680–1940, situating this development in a wider European context. It discusses a broad variety of general human subjects that are as important today as they were hundreds of years ago, such as love, death, family relations, religi
The liver possesses a remarkable regenerative capacity based partly on the ability of hepatocytes to re-enter the cell cycle and divide to replace damaged cells. This capability is substantially reduced upon chronic damage, but it is not clear if this is a cause or consequence of liver disease. Here, we investigate whether blocking hepatocyte division using two different mouse models affects physi
Satellite cell proliferation is an essential step in proper skeletal muscle development and muscle regeneration. However, the mechanisms regulating satellite cell proliferation are relatively unknown compared to the knowledge associated with the differentiation of satellite cells. Moreover, it is still unclear whether overload muscle fiber hypertrophy is dependent on satellite cell proliferation.
Left ventricular (LV) stroke work (SW) is calculated from the pressure-volume (PV) loop. PV loops do not contain information on longitudinal and radial pumping, leaving their contributions to SW unknown. A conceptual framework is proposed to derive the longitudinal and radial contributions to SW, using ventricular force-length loops reflecting longitudinal and radial pumping. The aim of this study
