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Caregiver-reported antiretroviral therapy non-adherence during the first week and after a month of treatment initiation among children diagnosed with HIV in Ethiopia

To achieve optimal virologic suppression for children undergoing antiretroviral therapy (ART), adherence must be excellent. This is defined as taking more than 95% of their prescribed doses. To our knowledge, no study in Ethiopia has evaluated the level of treatment adherence at the beginning of the child's treatment. Our aim was therefore to evaluate caregiver-reported ART non-adherence among chi

Institutional change and the optimal size of universities

The last years have been characterized by tremendous institutional change in the university sector induced by far-reaching Higher Education Reforms (e.g. Bologna). Building on loose-coupling theory, we hypothesize that smaller universities were better able to adapt to the Higher Education Reforms of the recent years, triggering a decline in the optimal size of universities in the reform period. Us

Learning to be inflexible : Enhanced attentional biases in Parkinson's disease

Impaired attentional flexibility is considered to be one of the core cognitive deficits in Parkinson's disease (PD). However, the mechanisms that underlie this impairment are contested. Progress in resolving this dispute has also been hindered by the fact that cognitive deficits in PD are heterogeneous; therefore, it is unclear whether attentional impairments are only present in a subgroup of pati

Two-year follow-up of temporal changes of breast edema after breast cancer treatment with surgery and radiation evaluated by tissue dielectric constant (TDC)

Background: Breast edema is reported as a common complaint after breast conserving surgery and radiotherapy (RT). Measurements of local water in skin and upper subeutis with tissue dielectric constant (TDC) technique have the potential to detect breast edema in patients after breast cancer treatment. Objective: The purpose of the present study was to examine development of edema in breast, axilla

Liposuction of lymphedema of the extremities

Lymphedema is the accumulation of lymph fluid in the interstice with secondary tissue changes. The accumulated lymph stimulates adipose tissue deposition, and a marked adipose tissue hypertrophy can be seen in patients with chronic lymphedema. The basis for all lymphedema treatment is adequate compression therapy. However, if the lymphedema has started to transform into adipose tissue, conservativ

Riksbanken feltolkar lagen i sin syn på inflationsmålet

Mot lagens anda. Riksbanken tycks ha feltolkat sitt uppdrag. Riksbankslagen erbjuder flexibilitet, trots det håller Riksbanken fast vid 2-procentmålet till nästan vilket pris som helst. Dessutom bryter man mot lagens anda när man köper statsobligationer för mångmiljardbelopp, skriver Fredrik NG Andersson, Andreas Bergh och Anders Olshov.

Rapid test for lung maturity, based on spectroscopy of gastric aspirate, predicted respiratory distress syndrome with high sensitivity

Aim: Respiratory distress syndrome (RDS) is a major cause of mortality and morbidity in premature infants. By the time symptoms appear, it may already be too late to prevent a severe course, with bronchopulmonary dysplasia or mortality. We aimed to develop a rapid test of lung maturity for targeting surfactant supplementation. Methods: Concentrations of the most surface-active lung phospholipid di

Evaluation of perfluorohexyloctane/polydimethylsiloxane for pancreas preservation for clinical islet isolation and transplantation

This study aimed to evaluate a 50:50 mix of perfluorohexyloctane/polydimethylsiloxane 5 (F6H8S5) preservation of pancreases in a clinical setting compared with standard solutions for 1) cold ischemia time (CIT) 20 h. Procured clinical-grade pancreases were shipped in either F6H8S5 or in standard preservation solutions, that is, University of Wisconsin (UW) or Custodiol. F6H5S5 was preoxygenated fo

Laparoscopic hepatectomy for HCC in elderly patients : risks and feasibility

Background: Laparoscopic liver resection (LLR) appears to be safe and effective as open liver resection (OLR) for hepatocellular carcinoma (HCC). However, studies comparing LLR with ORL in elderly patients are limited. The purpose of this study is to compare the clinical outcomes of LLR versus OLR for HCC in elderly patients. Methods: A retrospective analysis was made comparing laparoscopic (n = 1

Compressive loading of the murine tibia reveals site-specific micro-scale differences in adaptation and maturation rates of bone

Summary: Loading increases bone mass and strength in a site-specific manner; however, possible effects of loading on bone matrix composition have not been evaluated. Site-specific structural and material properties of mouse bone were analyzed on the macro- and micro/molecular scale in the presence and absence of axial loading. The response of bone to load is heterogeneous, adapting at molecular, m

The 2015 National Cancer Program in Sweden : Introducing standardized care pathways in a decentralized system

Starting in 2015, the Swedish government has initiated a national reform to standardize cancer patient pathways and thereby eventually speed up treatment of cancer. Cancer care in Sweden is characterized by high survival rates and a generally high quality albeit long waiting times. The objective with the new national program to standardize cancer care pathways is to reduce these waiting times, inc

Firm Size Distribution and Employment Fluctuations : Theory and Evidence

This paper studies the effect of the firm-size distribution on the relationship between employment and output. We construct a theoretical model, which predicts that changes in demand for industry output have larger effects on employment in industries characterised by a distribution that is more skewed towards smaller firms. Industry-specific shape parameters of the firm size distributions are esti

Perceived and objective entrance-related environmental barriers and daily out-of-home mobility in community-dwelling older people

Purpose We studied whether entrance-related environmental barriers, perceived and objectively recorded, were associated with moving out-of-home daily in older people with and without limitations in lower extremity performance. Methods Cross-sectional analyses of the “Life-space mobility in old age” cohort including 848 community-dwelling 75–90-year-old of central Finland. Participants reported the

Vaccination against hepatitis B virus among people who inject drugs – A 20 year experience from a Swedish needle exchange program

Background People who inject drugs (PWID) are at particular risk of hepatitis B virus (HBV) acquisition, but often have poor access or adherence to HBV vaccination. Vaccination against HBV has been offered at a major Swedish needle exchange program (NEP) since 1994. The aim of this study was to evaluate vaccine completion and response rates, and the effect of sequential booster doses to non-respon

Rapid subglacial streamlined bedform formation at a calving bay margin

Using the LiDAR-derived Swedish national height model we have identified previously undescribed shallow streamlined glacial bedforms, small-scale drumlins, on the Närke plain in south-central Sweden. These drumlins could only be detected with high-resolution LiDAR, due to both their subtle size and forest cover. In this area the ice margin receded in a subaqueous environment with a proglacial wate