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Clinical aspects on central venous cannulation

Popular Abstract in Swedish Centrala venkatetrar (CVK) används främst inom intensivvården men även allt mer inom annan vård på och utanför våra sjukhus. Oftast används CVK för tillförsel av mediciner och närings-lösningar, men även för mätning av blodomloppet och för bloddialys vid njursvikt. En CVK är en decimeterlång, smal plastslang, som med hjälp av en nål och en tunn metalledare förs in mot hCentral venous catheters are mainly being used for reliable infusion of fluids and potentially irritant drugs, for haemodialysis, and for assessment of right atrial or central venous pressure (RAP/CVP). Current guidelines state that central venous catheterization should be followed-up by immediate anterior-posterior chest X-ray to confirm appropriate positioning and to detect iatrogenic pneumothor

Knocking on heaven's door: The evaluation community goes to church

Ideas and concepts about evaluation travel around the globe. Studies of how evaluation models are disseminated, diffused and implemented are important. In this article, we examine an organization with a history of traditions and legitimacy and a successful audit of its own and how it responds to modern concepts of administration where evaluation plays an important role. Based on an analytical fram

Det fackliga medlemsraset i Sverige under 2007 och 2008

Den fackliga organisationsgraden är fortfarande mycket hög i Sverige. Sedan de svenska a-kasseavgifterna höjts kraftigt 2007 inträffade ett fackligt medlemsras utan motsvarighet i Sveriges moderna historia. Arbetsgivarnas organisationsgrad (definierad som andelen löntagare i företag och förvaltningar som tillhör en arbetsgivarorganisation) är numera betydligt högre än löntagarnas. Artikeln redovisUnion density still is very high in Sweden. The considerably raised fees to union unemployment funds made by the centre-right government in January 2007 have caused a fall of union density of a magnitude quite unique in modern Swedish history: from 77% in 2006 to 71% in 2008 (annual averages; full-time students working part-time excluded). In private sector union density declined from 71% in 2006

Noncollective aligned and antialigned states in I-125

High-spin states in I-125 were populated using the reaction Se-82(Ca-48, p4n) at a beam energy of 200 MeV and gamma-ray coincidence events were acquired with the Gammasphere spectrometer. The level scheme of I-125 was extended considerably. In particular, maximally aligned states involving all eleven particles outside the Sn-114 core were observed. Comparison with cranked Nilsson-Strutinsky calcul

Musikaliskt lärande som social rekonstruktion. Musikens och ursprungets betydelse för föräldrar med utländsk bakgrund.

In Swedish higher formal aesthetic education, students from ethnic minorities are significantly underrepresented. This also seems to be the case in music education for younger children. Accordingly, the relationship between music education and the ethnic diversity of the contemporary Swedish society, not reflected in the selection of students to the Swedish music and culture schools, is of vital iIn Swedish higher formal aesthetic education, students from ethnic mi-norities are significantly underrepresented. This also seems to be the case in music education for younger children. Accordingly, the relation-ship between music education and the ethnic diversity of the contem-porary Swedish society, not reflected in the selection of students to the Swedish music and culture schools, is of vita

Genetics of Osteoporosis - Studies on bone size, structure and strength in the rat

Osteoporosis is characterized by decreased bone mineral density (BMD) leading to reduced bone strength and increased fracture risk. Several heritable components affect a bone’s ability to resist fracture, including size, structure and strength; therefore identification of the genes underlying several bone characteristics will help elucidate the pathogenesis of fracture risk. Dissection of the gene

Pyruvate dehydrogenase kinase 1 controls mitochondrial metabolism and insulin secretion in INS-1 832/13 clonal beta-cells

Tight coupling between cytosolic and mitochondrial metabolism is key for GSIS (glucose-stimulated insulin secretion). In the present study we examined the regulatory contribution of PDH (pyruvate dehydrogenase) kinase 1, a negative regulator of PDH, to metabolic coupling in 832/13 clonal beta-cells. Knockdown of PDH kinase 1 with siRNA (small interfering RNA) reduced its mRNA (>80 %) and protein l

Exercise physiology and cardiac function. Aspects on determinants of maximal oxygen uptake

Although the athlete's heart has been of interest for over 100 years, further characterization of the athletes heart is needed in order to understand how training affects cardiac dimensions and function. Few studies have investigated the effects of training in female athletes and few have compared males and females. Therefore, the aim of this thesis was to characterize the physiologically enlarged

A model-based methodology for the analysis and design of atomic layer deposition processes-Part I: Mechanistic modelling of continuous flow reactors

This paper presents the development of an experimentally validated model that mechanistically comprehends the complex interaction between the gas-phase fluid dynamics, the mass transport of individual species, and the heterogeneous gas-surface reaction mechanism in a continuous cross-flow atomic layer deposition (ALD) reactor. The developed ALD gas-surface reaction mechanism, purely based on conse

Palladium(II)-Catalyzed Oxidative Cyclization of Allylic Tosylcarbamates: Scope, Derivatization, and Mechanistic Aspects

A highly selective oxidative palladium(II)-catalyzed (Wacker-type) cyclization of readily available allylic tosylcarbamates is reported. This operationally simple catalytic reaction furnishes tosyl-protected vinyl-oxazolidinones, common precursors to syn-1,2-amino alcohols, in high yield and excellent diasteroselectivity (>20:1). It is demonstrated that both stoichiometric amounts of benzoquinone

The Pancreatic Tumour Microenvironment. Influence by macrophages and glucose levels on tumourigenesis.

Popular Abstract in Swedish Vad har Nobelpristagaren i medicin 2011, huvudpersonen i Dirty Dancing, en av världens främsta tenorer och grundaren av Apple gemensamt? De drabbades alla av olika typer av bukspottkörtelcancer. Bukspottkörtelcancer är en av våra värsta cancerformer. Den drabbar årligen ca 1000 personer och 5-årsöverlevnaden är lägre än 5%. Den enda chansen till bot är via kirurgi, men Pancreatic cancer is the fourth cause of cancer-related death with a 5-year survival rate less than 5%. Two of the risk factors are chronic pancreatitis and type 2 diabetes (T2D), which are believed to promote the tumour progression. Pancreatic cancer and its tumour microenvironment is characterised by a dense stroma, immune cell infiltration and poor vascularisation. This creates a favourable env

Association of estrogen receptor-alpha A908G (K303R) mutation with breast cancer risk

Genetic mutations in premalignant breast lesions may have a role in malignancy progression or influence the behavior of subsequent disease. A point mutation in estrogen receptor-alpha (ER-&ALPHA) as A908G (Lys303 -> Arg) was originally involved to hypersensitive to estrogen breast hyperplasia. We detected this mutation among Iranian women with invasive breast cancer. A population-based case-co

Rheumatoid Arthritis: Body Composition, Bone Loss, and Mortality

Early rheumatoid arthritis (RA) patients (disease duration ≤1 year, n=165) were recruited 1995-2001 and followed systematically clinically and with dual energy X-ray absorptiometry (DXA) over 2 years and compared to age- and gender-matched controls. Baseline arm and leg lean mass were decreased in RA patients in both genders and body mass index and truncal fat distribution were increased in female

Approximate Optimal Periodogram Smoothing for Cepstrum Estimation using a Penalty Term

The cepstrum of a random process is useful in many applications. The cepstrum is usually estimated from the periodogram. To reduce the mean square error (MSE) of the estimator, the periodogram may be smoothed with a kernel function. We present an explicit expression for a kernel function which is approximatively MSE optimal for cepstrum estimation. A penalty term has to be added to the minimizatio

Identification of core T cell network based on immunome interactome.

Data-driven studies on the dynamics of reconstructed protein-protein interaction (PPI) networks facilitate investigation and identification of proteins important for particular processes or diseases and reduces time and costs of experimental verification. Modeling the dynamics of very large PPI networks is computationally costly.